ID   A0A9N8K9K6_9PEZI        Unreviewed;       950 AA.
AC   A0A9N8K9K6;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   18-JUN-2025, entry version 10.
DE   RecName: Full=Flap structure-specific endonuclease {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AWRI4620_LOCUS1845 {ECO:0000313|EMBL:CAD0107590.1};
OS   Aureobasidium uvarum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX   NCBI_TaxID=2773716 {ECO:0000313|EMBL:CAD0107590.1, ECO:0000313|Proteomes:UP000745764};
RN   [1] {ECO:0000313|EMBL:CAD0107590.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Onetto C.;
RL   Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CAD0107590.1}.
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DR   EMBL; CAINUL010000002; CAD0107590.1; -; Genomic_DNA.
DR   OrthoDB; 2959108at2759; -.
DR   Proteomes; UP000745764; Unassembled WGS sequence.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:TreeGrafter.
DR   GO; GO:0008821; F:crossover junction DNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-ARBA.
DR   CDD; cd09906; H3TH_YEN1; 1.
DR   CDD; cd09870; PIN_YEN1; 1.
DR   FunFam; 3.40.50.1010:FF:000037; Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260); 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR041177; GEN1_C.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   InterPro; IPR006084; XPG/Rad2.
DR   InterPro; IPR006085; XPG_DNA_repair_N.
DR   InterPro; IPR037316; Yen1_H3TH.
DR   PANTHER; PTHR11081:SF75; ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED; 1.
DR   PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR   Pfam; PF18380; GEN1_C; 1.
DR   Pfam; PF00867; XPG_I; 1.
DR   Pfam; PF00752; XPG_N; 1.
DR   PRINTS; PR00853; XPGRADSUPER.
DR   SMART; SM00484; XPGI; 1.
DR   SMART; SM00485; XPGN; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000745764}.
FT   DOMAIN          17..106
FT                   /note="XPG N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00485"
FT   DOMAIN          127..202
FT                   /note="XPG-I"
FT                   /evidence="ECO:0000259|SMART:SM00484"
FT   REGION          416..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          694..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          859..887
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..440
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        542..553
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        653..667
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        782..797
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        859..872
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   950 AA;  104425 MW;  9B4F230C0FE8D563 CRC64;
     MGESQGAPRL AEASTHMFCS IYKEIGPGQR IAVSKLAAEH YIQHSRPFRL AIDISIWLFQ
     IQSGKGGTNP ALRTFYYRLL RLLSLNIHPL FVFDGPNKPT WKRNKKVGGP NVRVSSVPEF
     LAKQLLKHFG FPLHYAPGEA EAECALLQRE GIVDAVLSED VDTLMFGSGM TLRSWTPEQK
     SSKTPTHVNV YRADATKETS GLDRNGMILV AMMSGGDYIT EGIPGCGPKL ACEAARAGFG
     DELCTLDKKD TDGLNTWRDK LRHEIRTNES KHFRQKRPGL TIPDTFPDQK VLSYYTHPCI
     SAPEKIARLK DTLKWDMPLD YPSLRDFAGD AFDWRCIGGA XKFIRNLAPA VLVRELRMRG
     EAAETHGGGL SAQKARESSL VNAIHGKRLH PTTDNIPELR ISFKPIELID IDLSTEDPDE
     EVPEDEEDSD SEPLPTEDGE CPGSPKKKRG PSTYDPTVHD KVWLLDTFVR LGAPLKVQDW
     EAGVVTKSKP APRLRKAATN QATAGRIPAA TKKTGGMQRG ALDQFTKTAK PGVDRTAQSK
     SKSPECDELD LSRIDALAKQ SAGEKEPIAK AAPKSNSFRI RAAVTELDVS GGTSSRTPSI
     PELDLSLEAI VPQKRNSKRS SPEPASPFRR ARPRMVSPAR KASGTPEIVD LLSSSPVKPV
     SPKAAPVRTT SIQDQFKQFD KALAASPRND FDTIAPLRDT VTRRRRRSPL KRFQTAPTTG
     ADEMESPSLR PSTPRGPDLE AIDLASPESL PSLPRFGAVQ RVSDKTRQAV AHSTMPTPSA
     KPTVRTSASS SRVTPAPLDE EVEVLELQSS MPTPPYEPEL PKKTPNIERP VISVSALLPI
     NKRLRDRKVE ATVTKVTATA TNSSSATGSS TAKARHDHST GDMQSTSTIE NQQLLQTPAN
     KVKKRFIQPR DSLPGKWKDV VMEVDLTEPT PRDRRMYRKS GVEELDLTGD
//