UniProt: A0A9P0B8F0

Database: UniProt
Entry: A0A9P0B8F0_BRAAE

LinkDB:  A0A9P0B8F0_BRAAE 
Original site:  A0A9P0B8F0_BRAAE

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Ontology (9)   
   GO (9)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (8)   
   Pfam (3)   
   PROSITE (1)   
   SMART (1)   
All databases (24)   

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ID   A0A9P0B8F0_BRAAE        Unreviewed;       515 AA.
AC   A0A9P0B8F0;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   28-JAN-2026, entry version 13.
DE   RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE            EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN   ORFNames=MELIAE_LOCUS9849 {ECO:0000313|EMBL:CAH0559995.1};
OS   Brassicogethes aeneus (Rape pollen beetle) (Meligethes aeneus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia; Nitidulidae;
OC   Meligethinae; Brassicogethes.
OX   NCBI_TaxID=1431903 {ECO:0000313|EMBL:CAH0559995.1, ECO:0000313|Proteomes:UP001154078};
RN   [1] {ECO:0000313|EMBL:CAH0559995.1}
RP   NUCLEOTIDE SEQUENCE.
RA   King R.;
RL   Submitted (DEC-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC       {ECO:0000256|ARBA:ARBA00010107}.
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DR   EMBL; OV121138; CAH0559995.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A9P0B8F0; -.
DR   OrthoDB; 787137at2759; -.
DR   Proteomes; UP001154078; Chromosome 7.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:TreeGrafter.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005705; C:polytene chromosome interband; IEA:UniProtKB-ARBA.
DR   GO; GO:0003682; F:chromatin binding; IEA:UniProtKB-ARBA.
DR   GO; GO:0046972; F:histone H4K16 acetyltransferase activity; IEA:TreeGrafter.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0140861; P:DNA repair-dependent chromatin remodeling; IEA:UniProtKB-ARBA.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:TreeGrafter.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd04301; NAT_SF; 1.
DR   FunFam; 1.10.10.10:FF:000022; Histone acetyltransferase; 1.
DR   FunFam; 2.30.30.140:FF:000013; Histone acetyltransferase; 1.
DR   FunFam; 3.30.60.60:FF:000001; Histone acetyltransferase; 1.
DR   FunFam; 3.40.630.30:FF:000002; Histone acetyltransferase; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 3.40.630.30; -; 1.
DR   Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR002717; HAT_MYST-type.
DR   InterPro; IPR050603; MYST_HAT.
DR   InterPro; IPR025995; Tudor-knot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR040706; Zf-MYST.
DR   PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR10615:SF219; HISTONE ACETYLTRANSFERASE KAT5; 1.
DR   Pfam; PF01853; MOZ_SAS; 1.
DR   Pfam; PF11717; Tudor-knot; 1.
DR   Pfam; PF17772; zf-MYST; 1.
DR   SMART; SM00298; CHROMO; 1.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   SUPFAM; SSF54160; Chromo domain-like; 1.
DR   PROSITE; PS51726; MYST_HAT; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP001154078};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          182..460
FT                   /note="MYST-type HAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51726"
FT   REGION          77..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        358
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ   SEQUENCE   515 AA;  59293 MW;  CA12F82A31CBAC25 CRC64;
     MKVEMENDYN TICDSVSSLI EGCRLSVRMK GTNDWPLAEI ISIKEAIGVK EYYVHYVDFN
     KRLDEWVTEH DLDTRKVHFP RKDGGGSNTG VSTPKKAQIG SGPVVLTQSQ SANVSGAVSR
     PSSPVNNTEL LNGNAVLAAA LQKRMNRKRK IPSLESEDSN EGPVPQPRQS GSMVSHHDDI
     VTRMKNIDLI ELGKHRIKPW YFAPYPQEMV NLDCIYICEF CLKYRKSRKC LERHLKKCNL
     RHPPGNEIYR KDIISFFEID GRKNKVYAQN LCLLAKLFLD HKTLYYDTDP FLFYVMTVFD
     NRGFHIVGYF SKEKESTEDY NVACILTMPP YQRKGYGKLL IEFSYELSKF EGKTGSPEKP
     LSDLGLLSYR SYWAQTILEI LLDMKPVGDN EKPQITINEI CELTSIKKED VISTLQNLNL
     INYYKGQYII TLSRDIIENH HRAMESRKIR IDPKCLHWVP KDWGKRAKWN QSQNRRSSRG
     LSLSSQVNAE VEVKPDWVDL EEPLLIALDQ IQVNV
//

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