ID A0A9P0HKS0_NEZVI Unreviewed; 1353 AA.
AC A0A9P0HKS0;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=RNA helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEZAVI_LOCUS12295 {ECO:0000313|EMBL:CAH1403730.1};
OS Nezara viridula (Southern green stink bug) (Cimex viridulus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Pentatomomorpha; Pentatomoidea; Pentatomidae; Pentatominae; Nezara.
OX NCBI_TaxID=85310 {ECO:0000313|EMBL:CAH1403730.1, ECO:0000313|Proteomes:UP001152798};
RN [1] {ECO:0000313|EMBL:CAH1403730.1}
RP NUCLEOTIDE SEQUENCE.
RA King R.;
RL Submitted (JAN-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; OV725081; CAH1403730.1; -; Genomic_DNA.
DR OrthoDB; 6103986at2759; -.
DR Proteomes; UP001152798; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-ARBA.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR FunFam; 3.30.1370.50:FF:000002; Immunoglobulin mu DNA-binding protein 2; 1.
DR FunFam; 1.20.120.1080:FF:000008; probable ATP-dependent RNA helicase YTHDC2; 1.
DR FunFam; 3.40.50.300:FF:000284; probable ATP-dependent RNA helicase YTHDC2; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR059023; RNA_hel_CTD.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF26026; RNA_hel_CTD; 1.
DR Pfam; PF04408; WHD_HA2; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50882; YTH; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP001152798};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 16..80
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 175..341
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 459..491
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 565..737
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1195..1328
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1131..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1353 AA; 150708 MW; 630E0FEB5BEAE2DE CRC64;
MSRKKKMNQQ PINVGEAVKI CVEVTIKKFL NSEELKEWEY PSSFTAKERA YIHNEAKKYG
LKSKSRGKGS SRYLTIYKRE ASAIMEKDAT MSLTPASRTL MMSMLTKHPV TTRERQDCLP
PVERCKDLYQ DGKDGSRALG RMSGGTPQVP PPVTTKAYAQ FRASLPVAAL QDIIVQTVAE
NQVTIIAGET GSGKTTQVPQ FLLEWHEKTG RPCRIVCSQP RRISAVSVAE RVATERGDKV
GQSVGYQIRL EGKVSPYTVL MYCTNGVLLR TLMTGESVLA TVTHIIVDEV HERDRLSDFV
LIVLREALAK FRSLRLILMS ATADSSTLSS YFNNCPVITV PGKLFEVKEH HLEDILKQTG
YMTSEMEKMR KDLEKKKAQA AQLDKWAEAV RDDASMTSSA SAQLLASNST QGHEDVGTCK
EMDEAIQEAW LTASDAAFAQ LLYLLQNEVV NVDYQHSNTG ISSLMVAAAR GSAEVIEQLL
ALGANLLLEA SNGYSAIKFA ECFNRVEIVD ILRAHETLLA VSNFDSNTNE IAVERKLSDV
DKELLELYHC SFNDNFIDMK LLMVLISQIH VENINKGSIL VFLPGYEDIM TLKELLISEE
RRMSQKTKVL ILMLHSNMQT SEQKLVFKPT PINTRKIILS TNIAETSITI DDISYVIDTG
KMKEKSYNAL TGVSQLCTVW VSKSCAIQRK GRAGRTGPGI CYRLYSSLRY EALQQHATPE
ILRVPLQELC LYAKQLAPPN TSIVDFLSRA LDPPSSMASR SAVSLLKTID ALDTWEDLTD
LGHHLLDFPI EPRYGKMLIY ASVLKCLDPV LTIVCCLSYR DVFILPMAAG KKKDVHAERA
RFAAGSLSDH MVLLRVFQSW QEARKQGRGR QFCQQHYING AAMEMILGTR AQVLAQLRAS
GFIKSKGHGD IKYVNANSDN WAVVKAAIAG GLYPNIARVD RQHNILRTVK EHKVRLHCTS
VLHDGNKGSV TYFPTEWVAF EELSRSSTVC HIRTATVLSP ITVAVFASPR AIPYDALSDT
HIEGSLCSDS EEEEVGPEET ATLKVDDWAT FRTDSETAQL ALQLRVKWHS LLSKKLRWTH
KVLNTMDELV INTIVRVLSA EEQAARLSAP PGVGKRPYLM TPDLPAIGNR TLDYSDGLND
SHNDRRNQGT ASPSKSNFER FNNGTNKSFE ETSPTQTAFS SGGIEAQRAN CASPFRYFVI
KAGQLKNIDI SVVHKMWAFL PTTQSRLVQA LKAGKSVILV FSIQGSGHFQ GYAHLAGENP
VTGEIPLDLS GNHSLSAPLP VEWIKRGNIP YHATRHLFNP YNDYAKVQTS RDGQEIEPSV
GEALCQLWDS LQWFPRPARV VRPTPYHASS YKM
//
