ID A0A9P1DCM2_9DINO Unreviewed; 1568 AA.
AC A0A9P1DCM2;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE RecName: Full=CobW C-terminal domain-containing protein {ECO:0000259|SMART:SM00833};
GN ORFNames=C1SCF055_LOCUS31817 {ECO:0000313|EMBL:CAI4006153.1};
OS Cladocopium goreaui.
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Cladocopium.
OX NCBI_TaxID=2562237 {ECO:0000313|EMBL:CAI4006153.1};
RN [1] {ECO:0000313|EMBL:CAI4006153.1}
RP NUCLEOTIDE SEQUENCE.
RA Chen Y., Dougan E. K., Chan C., Rhodes N., Thang M.;
RL Submitted (OCT-2022) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAL1159528.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Chen Y., Shah S., Dougan E. K., Thang M., Chan C.;
RL Submitted (APR-2024) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + phosphate + H(+); Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00049117};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00049117};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAI4006153.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CAMXCT010003779; CAI4006153.1; -; Genomic_DNA.
DR EMBL; CAMXCT020003779; CAL1159528.1; -; Genomic_DNA.
DR EMBL; CAMXCT030003779; CAL4793465.1; -; Genomic_DNA.
DR OrthoDB; 272672at2759; -.
DR Proteomes; UP001152797; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_nucleotide-bd.
DR InterPro; IPR014955; DUF1826.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR051927; Zn_Chap_cDPG_Synth.
DR PANTHER; PTHR43603; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR PANTHER; PTHR43603:SF1; ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR Pfam; PF08856; DUF1826; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP001152797};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1140..1163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1175..1196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1217..1247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1332..1351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1394..1414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1429..1452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 933..1042
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
FT REGION 225..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..280
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1568 AA; 173073 MW; 1A86820B08139CAD CRC64;
MYYVCKGCSD CVEGGCTACS KCCKSVETAC DSVCQGLGTC LGSVCVPCAV IWSRPLGMYV
VLCWAFNLPA LIASVYSLVQ AEDCVRNLKA LLLGNAIFSF VHAGFALYLQ TRLFHGLQKA
AEGLAQPPTA KEQMKRAWDI ILYDFGFLFY LFVFFGSFGF NCYASGWAFS CGADFLAFLP
SLLLILFFLA AMQFAVLWFF VLSCTDCCQS SPIARVVLGV KPSHPSQTAP PTVVGQPVVG
KPAGPPQQQM PGASPAQAMY VPAQPQQPQQ AYTPTAPPAA SSNSPAGQEK PSAGQQAAQT
AAAGAAVAFD MGKAGLKKVG GWLQKKYFDQ ELVTGTTSSD CQGQVEELLC TADVATEDRA
IFDAEQMMLK TLEGSKDSTA CADCDGVAGP DNAGVAQKIR IESDRNGAVL KGFVSDNGDN
VLLSWAQDFC ALGEHVKGQL CYYEGHLAKP GESFPQQLQQ KLETDFTRRG QALVERGVLK
ENTEIAKGSP SAVQALFQML QELMRLHESC MEEGQDLRWK IKVEINQNCA CTKYHDDSVK
VRFAMTLAGD GTVLADNAQV DWNYYEACEG IIPELAENPD AKAEAAHRII ETWNERVCKG
YTETQPGDVV IMKGGKLTKF PCLHRAPYSA GEGRNPARFL ITIDHIPADE LQEFVDMDLV
DDEDEEMIEA SEAKPAADGL LPVTVLSGFL GAGKTTLLSH VLQNQEGLRV AVIVNDMAEV
NIDGLLVKDS KVLAGEDKML EMQNGCICCT LRQDLIENVT QLAKEKRFDY LLIESTGISE
PMPVATTFVA EHEGKNLLGS VARLDTLVTV VDAVNFFKDY NNGVEKLRER SALGAEATDE
RTISSLLTDQ VECANLIVLN KMDLVKESDA SVLEGFCKKL NPKAKIIRSR FGKVDLKLLL
DTKSFDMAEA EEMPGWYQEL QGNHVPETIE YGISSFVFRS QKPFHPTRLN KLLRRGLDRV
LRSKGVLWVA GLNVHCLVWH QAGETLSIDD GAQWLAATDL AEWPPELESY KTSTYGDRRQ
ELVVIGQQLD QTALRKQLEQ ALVTEEEFQM GPQVWDKWPN VFKPQKAAAF SAKQCGAEAY
LIFETRSGRD KALSTLSRGF SFRGNHLSMA VARHEPRSIQ WQNYDRSPHS LKWWKISKGI
GCIIFGLIVW ACIFYLPYAW SIFTFNYEGG RQPGIIYSLS FSIIVVVGNV SMYQICAAVA
DHVGFKYKET REACYMILYF ISITLNVLLD LVMTYFMSFA IMVHLGFRTH DGIPLTKLPY
FVQRFEAYAI QRAMGQNLYD YAFPSTFLLP FLGEPVMAVC GLLRLGILVV RSHPELSQRA
AMVLLAAPDF EFGRYADTLV NVVLAVTMFF FPGGYTHWIF FMLAVSQAYI YLLDHYRVLR
VVPASTFASM QIDWWCQVLL APCCGLLAAC LIFKGNCQGL GFCLDPSRLV LACMAAWLVH
CVIHLLLLIF VVPLGDTSLP VKGQDPIRYQ QVAAAEPCNW FSANAVHCLR SKYIHCDDPS
SSFFTPGQES TMQINEAIGC FFSAKAAKVE NASDFDIRLP AALSRWNCAL PAATFWKKAE
DGTSDPPS
//
