ID A0A9P4GX96_9PLEO Unreviewed; 749 AA.
AC A0A9P4GX96;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN ORFNames=EK21DRAFT_118536 {ECO:0000313|EMBL:KAF2023665.1};
OS Setomelanomma holmii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Setomelanomma.
OX NCBI_TaxID=210430 {ECO:0000313|EMBL:KAF2023665.1, ECO:0000313|Proteomes:UP000799777};
RN [1] {ECO:0000313|EMBL:KAF2023665.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 110217 {ECO:0000313|EMBL:KAF2023665.1};
RA Haridas S., Albert R., Binder M., Bloem J., Labutti K., Salamov A.,
RA Andreopoulos B., Baker S., Barry K., Bills G., Bluhm B., Cannon C.,
RA Castanera R., Culley D., Daum C., Ezra D., Gonzalez J., Henrissat B.,
RA Kuo A., Liang C., Lipzen A., Lutzoni F., Magnuson J., Mondo S., Nolan M.,
RA Ohm R., Pangilinan J., Park H.-J., Ramirez L., Alfaro M., Sun H., Tritt A.,
RA Yoshinaga Y., Zwiers L.-H., Turgeon B., Goodwin S., Spatafora J., Crous P.,
RA Grigoriev I.;
RT "101 Dothideomycetes genomes: a test case for predicting lifestyles and
RT emergence of pathogens.";
RL Stud. Mycol. 0:0-0(2020).
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF2023665.1}.
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DR EMBL; ML978331; KAF2023665.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9P4GX96; -.
DR OrthoDB; 21502at2759; -.
DR Proteomes; UP000799777; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0000250; F:lanosterol synthase activity; IEA:TreeGrafter.
DR GO; GO:0006696; P:ergosterol biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR FunFam; 1.50.10.20:FF:000003; Terpene cyclase/mutase family member; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 6.20.120.20; -; 1.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000799777};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955}.
FT DOMAIN 126..296
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 407..740
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 86353 MW; BC5D5FFF53F17BB9 CRC64;
MPRANGTANG TANGATKRGT TAKQIPLKEQ KAGHEQTDYI RWRLKDDRGC QTWHYLKSEE
EIREWPQSTA DKYFLGLETG LPTLQPAKTP LEVATNGLAF FSHLQLPPGN WGCEYGGPMF
LLPGLVITWY VTETPIPEDH AIEIKRYLFN RQHTEDGGWG LHIEGDSSVF GTAMNYTTLR
ILGADAEDPR MQKARDTLWK LGGALKGPHW AKFWLSVLGV LEWDVVNPVP PELWLLPDWV
PVAPWRWWIH MRQVFLPMSY VYSKRWSYPL NDLTRSLRAE LLTQPFETIT FGKHRNDISP
MDDYHPKTWI LKVIFWFLVV IWSPYLRWED LAKKAEDHVW WLIEAEDENT DYANLGPVNG
PMNTLASYIK GGKDFQPFRE HIKTLPEFLW MKDEGMLMNG TNGVQSWDTS FVVQAADSCG
FIEDPRWKPM LTKALEFLED QQILEECRDR HLCYRQQRKG AWGFSTRKQG YTVSDCTSEG
LKAALILQNE HKYPTLISER RQKDAIDVVL TMQNASGGCA SYEPTRGSVY LEHLNAAEVF
GNIMIEYDYP ECTTAVVTAL HMFQKYYPDY RADEIKAFKD RAVAYIRRAQ RPDGSWYGSW
GICFTYAAMF ALESLACVGE TYQSSERVRR ACQFFVDKQM EDGGWGETYR SCESGVWSQH
PQSQVVQTAW VVIAMLEGGF GEEKGQREVL RRAVRLIMER QQENGEWLQE AIEGVFNKSC
MISYPNYKFI FPIKALGMYA KRFGNEKIL
//
