ID A0A9P6IVT1_MORAP Unreviewed; 876 AA.
AC A0A9P6IVT1;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE RecName: Full=Glucosidase II subunit alpha {ECO:0000256|ARBA:ARBA00042895};
DE Flags: Fragment;
GN ORFNames=BGZ70_001487 {ECO:0000313|EMBL:KAF9950152.1};
OS Mortierella alpina (Oleaginous fungus) (Mortierella renispora).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mortierellomycotina;
OC Mortierellomycetes; Mortierellales; Mortierellaceae; Mortierella.
OX NCBI_TaxID=64518 {ECO:0000313|EMBL:KAF9950152.1, ECO:0000313|Proteomes:UP000738359};
RN [1] {ECO:0000313|EMBL:KAF9950152.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CK1249 {ECO:0000313|EMBL:KAF9950152.1};
RX PubMed=33364917;
RA Vandepol N., Liber J., Desiro A., Na H., Kennedy M., Barry K.,
RA Grigoriev I.V., Miller A.N., O'Donnell K., Stajich J.E., Bonito G.;
RT "Resolving the Mortierellaceae phylogeny through synthesis of multi-gene
RT phylogenetics and phylogenomics.";
RL Fungal Divers. 104:267-289(2020).
CC -!- PATHWAY: Glycan metabolism; N-glycan metabolism.
CC {ECO:0000256|ARBA:ARBA00004833}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF9950152.1}.
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DR EMBL; JAAAHY010001335; KAF9950152.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9P6IVT1; -.
DR OrthoDB; 3237269at2759; -.
DR Proteomes; UP000738359; Unassembled WGS sequence.
DR GO; GO:0017177; C:glucosidase II complex; IEA:TreeGrafter.
DR GO; GO:0090599; F:alpha-glucosidase activity; IEA:TreeGrafter.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006491; P:N-glycan processing; IEA:TreeGrafter.
DR CDD; cd06603; GH31_GANC_GANAB_alpha; 1.
DR CDD; cd14752; GH31_N; 1.
DR FunFam; 3.20.20.80:FF:000046; Glucosidase alpha, neutral C; 1.
DR FunFam; 3.20.20.80:FF:000039; Glucosidase, alpha neutral C; 1.
DR FunFam; 2.60.40.1180:FF:000023; neutral alpha-glucosidase AB isoform X2; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 2.
DR InterPro; IPR033403; DUF5110.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR017853; GH.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF54; BCDNA.GH04962; 1.
DR Pfam; PF17137; DUF5110; 1.
DR Pfam; PF13802; Gal_mutarotas_2; 1.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361185};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361185};
KW Reference proteome {ECO:0000313|Proteomes:UP000738359};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 13..258
FT /note="Glycoside hydrolase family 31 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13802"
FT DOMAIN 321..649
FT /note="Glycoside hydrolase family 31 TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF01055"
FT DOMAIN 657..744
FT /note="Glycosyl hydrolase family 31 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21365"
FT DOMAIN 763..802
FT /note="DUF5110"
FT /evidence="ECO:0000259|Pfam:PF17137"
FT REGION 117..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 876
FT /evidence="ECO:0000313|EMBL:KAF9950152.1"
SQ SEQUENCE 876 AA; 99337 MW; 0210967042F1AF29 CRC64;
EDVQPSPRPG LGFELHLLDN DAVRVRISER DPIHPRYDGV KDTVLVKPYG MAQEDTYQRI
AKDDSGVLTV QYGAQNQNTI KVSSAPFKIE FLANGVPTVL LNEEGLLRFE RLRTKQQEQE
NTDENKLVDQ DGESKEGEIK VEKSALEQKL EENMWEEKFK EFTDSKPRGP ESFGMDITFS
GINHVYGIPE HASSLSLKAT KGQDAPYSEP YRLYNLDVFE YETDNPMALY GSVPFMLGHS
KNSTAAVFWM NAAETWVDVE KSAEDKSGGI LSWIKSKKGT SAPTTKTHWI SEAGVLDLFV
FLGPTQRDIF RQYSSLVGTT ALPQAFSIAY HQCRWNYNNQ QDVAEVDAGF DEHDIPYDVL
WLDIEHTNGK RYFTWDDAKF PNPTDMQQSL GAKGRKMVTI IDPHIKKDGD YHVSKEGAEL
DVYIKNKDGD SDFDGWCWPG SSQWIDFYNP KARDWWASLF SYDRYKASTK DLFTWNDMNE
PSVFSGPEIT IPKDVIHYGK VEHRNVHNLY GTMFHSATAQ GLTQRNETNQ RPFVLSRAFF
AGTQRFGAIW TGDNLATWEH LEIASPMLLT IGLSGIPFSG ADVGGFFGNP EPELLTRWYQ
AGIYYPFFRA HAHLDSRRRE PWLFGEPYTT QIREAVRARY ALLPFWYTLF QESSVDGMPI
IRPMFTEFPE DETVFGMDDQ YMVGDALLVK PVTKPGVTRS SVYFAGNEKW FDIKDYSVEQ
GPGIREVDSP ANKIPVYQRA GTIIPRRERP RRSSKAMEND PFTLVIALDS KGEATGRIYL
DDGESFNYEK GDYILREFHV ANGVLRSRDL RTAGIDKPSE FVQRVGALRI ERLVILGSTK
PLKSAECAAA PIGGSYVCTV KEPQVAIGEE FEVKLA
//
