ID A0A9P6M166_MORAP Unreviewed; 768 AA.
AC A0A9P6M166;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=Squalene epoxidase ERG1 {ECO:0000256|ARBA:ARBA00070793};
DE EC=1.14.14.17 {ECO:0000256|ARBA:ARBA00012312};
DE AltName: Full=Squalene epoxidase erg1 {ECO:0000256|ARBA:ARBA00070252};
DE AltName: Full=Squalene monooxygenase ERG1 {ECO:0000256|ARBA:ARBA00080528, ECO:0000256|ARBA:ARBA00081105};
GN Name=ERG1_2 {ECO:0000313|EMBL:KAF9959666.1};
GN ORFNames=BGZ70_008785 {ECO:0000313|EMBL:KAF9959666.1};
OS Mortierella alpina (Oleaginous fungus) (Mortierella renispora).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mortierellomycotina;
OC Mortierellomycetes; Mortierellales; Mortierellaceae; Mortierella.
OX NCBI_TaxID=64518 {ECO:0000313|EMBL:KAF9959666.1, ECO:0000313|Proteomes:UP000738359};
RN [1] {ECO:0000313|EMBL:KAF9959666.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CK1249 {ECO:0000313|EMBL:KAF9959666.1};
RX PubMed=33364917;
RA Vandepol N., Liber J., Desiro A., Na H., Kennedy M., Barry K.,
RA Grigoriev I.V., Miller A.N., O'Donnell K., Stajich J.E., Bonito G.;
RT "Resolving the Mortierellaceae phylogeny through synthesis of multi-gene
RT phylogenetics and phylogenomics.";
RL Fungal Divers. 104:267-289(2020).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Microsome
CC membrane {ECO:0000256|ARBA:ARBA00004154}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004154}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the squalene monooxygenase family.
CC {ECO:0000256|ARBA:ARBA00008802}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF9959666.1}.
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DR EMBL; JAAAHY010000662; KAF9959666.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9P6M166; -.
DR OrthoDB; 1678617at2759; -.
DR Proteomes; UP000738359; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004506; F:squalene monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006696; P:ergosterol biosynthetic process; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR FunFam; 3.50.50.60:FF:000166; Squalene monooxygenase Erg1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR InterPro; IPR013698; Squalene_epoxidase.
DR InterPro; IPR040125; Squalene_monox.
DR PANTHER; PTHR10835; SQUALENE MONOOXYGENASE; 1.
DR PANTHER; PTHR10835:SF0; SQUALENE MONOOXYGENASE; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR Pfam; PF08491; SE; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000738359};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 468..582
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 663..768
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 625..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 83174 MW; C881308AAA69BCA1 CRC64;
MPGNTPTLPL ATVPAPKAGS SYDMIVVGGG VIGSAFAATF GKQGKKILLI ERDLTEPDRI
VGELMQPGGY NALKELGLAD CLEGIDAIPT HGYGVIRGSE HVHIPYTIDP ETGKPSQGRS
FHYGRFIQKL RAAASRTPNV TVVEATVNEV LYDQDGVRAT GVSCTAKSAT ETETAPALTY
KSPMVVIADG CFSKFRKQYL NKEVTVSSHF VGLILKDVVL PYPNHGHVIL MTPSPVLMYQ
ISKTETRILV DIPGKLPSVS TGALRSYLEK TIYPQLPATA QKPFLRALET DRLRSMPNSF
LPPSTSSELG IIVLGDAMNM RHPLTGGGMT VALNDVVYLR NMLKGDVTKD QEVTMVQMEL
FFWKRKELSA VINILAQALY ALFSGTDGNL LTLRDGCFSY FQMGGECIRG PVGLLSGLNR
SRKTLAYHFF HVAFHSIWLM FHNADSYADF PILLLKAINT APFNDMTSAS THLLEFKAGR
CFRTTGTDTV KPDPTKGLVY LDEEDGLMHF YWKNRATGDV EDDLILFPGD AELISVPQCT
TGRVVMLQFK SSSQKLFFWH QEASTDRDQI ILQQVNSLIH SQGDEDEEEY LEDVAMDGVE
GTASAVTSST PASIAPSAAF APAAPVVPGS ESQTSVTGSS SLTSQQMDQL RHLLGGIQVP
QAATAQRSNL RLDHVLTPGA VAPLLNNPQI CAALFPHLPE SSERTPEEIQ AIVRTPQFSQ
ALVSLSTALE SGQLGPLLRQ FGLGPNAGDG VEGFLSAIEE QAKKDGGK
//
