ID   A0A9P6RIP9_9FUNG        Unreviewed;       682 AA.
AC   A0A9P6RIP9;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   28-JAN-2026, entry version 9.
DE   RecName: Full=squalene monooxygenase {ECO:0000256|ARBA:ARBA00012312};
DE            EC=1.14.14.17 {ECO:0000256|ARBA:ARBA00012312};
GN   Name=ERG1_1 {ECO:0000313|EMBL:KAG0320558.1};
GN   ORFNames=BGZ99_004435 {ECO:0000313|EMBL:KAG0320558.1};
OS   Dissophora globulifera.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mortierellomycotina;
OC   Mortierellomycetes; Mortierellales; Mortierellaceae; Dissophora.
OX   NCBI_TaxID=979702 {ECO:0000313|EMBL:KAG0320558.1, ECO:0000313|Proteomes:UP000738325};
RN   [1] {ECO:0000313|EMBL:KAG0320558.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=REB-010B {ECO:0000313|EMBL:KAG0320558.1};
RX   PubMed=33364917;
RA   Vandepol N., Liber J., Desiro A., Na H., Kennedy M., Barry K.,
RA   Grigoriev I.V., Miller A.N., O'Donnell K., Stajich J.E., Bonito G.;
RT   "Resolving the Mortierellaceae phylogeny through synthesis of multi-gene
RT   phylogenetics and phylogenomics.";
RL   Fungal Divers. 104:267-289(2020).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SUBCELLULAR LOCATION: Microsome membrane
CC       {ECO:0000256|ARBA:ARBA00004154}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004154}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the squalene monooxygenase family.
CC       {ECO:0000256|ARBA:ARBA00008802}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAG0320558.1}.
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DR   EMBL; JAAAIP010000278; KAG0320558.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A9P6RIP9; -.
DR   OrthoDB; 1678617at2759; -.
DR   Proteomes; UP000738325; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:TreeGrafter.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0004506; F:squalene monooxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006696; P:ergosterol biosynthetic process; IEA:TreeGrafter.
DR   Gene3D; 1.10.2020.20; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR   InterPro; IPR044867; DEUBAD_dom.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR   InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR   InterPro; IPR032368; RPN13_DEUBAD.
DR   InterPro; IPR038108; RPN13_DEUBAD_sf.
DR   InterPro; IPR013698; Squalene_epoxidase.
DR   InterPro; IPR040125; Squalene_monox.
DR   PANTHER; PTHR10835; SQUALENE MONOOXYGENASE; 1.
DR   PANTHER; PTHR10835:SF0; SQUALENE MONOOXYGENASE; 1.
DR   Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR   Pfam; PF16550; RPN13_C; 1.
DR   Pfam; PF08491; SE; 1.
DR   PRINTS; PR00420; RNGMNOXGNASE.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS51916; DEUBAD; 1.
DR   PROSITE; PS51917; PRU; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000738325}.
FT   DOMAIN          336..494
FT                   /note="Pru"
FT                   /evidence="ECO:0000259|PROSITE:PS51917"
FT   DOMAIN          578..682
FT                   /note="DEUBAD"
FT                   /evidence="ECO:0000259|PROSITE:PS51916"
SQ   SEQUENCE   682 AA;  73168 MW;  365F547448CB7269 CRC64;
     MPGSNIIPVL ATCPVPESGS SFDVIVIGGG VLGASFAVTF GKQGQRVLMI ERDLSEPDRI
     VGELLQPGGY NALKELGLAD CLEGIDAVPA LGYGVIRGSE MVHIPYTKAT ANEILYDQDG
     VRATGVRCTA KKAAAAEAAE SSTSTVEYKS RMVVIADGCF SKFRAQYLTK NVETTSHFVG
     LVLKDAVLPF PNHGHVVLAT PSPILLYQIS STETRILIDI PGKLPSVSTG ALRSYLETII
     HPQLPTGVQK PFLRALETER LRSMPNSFLP PSTSSELGII VLGDAMNMRH PLTGGGMTVA
     LNDVVYLRDL LKDDALKDQE VTMVQMELFF WKRKELSAVI NILAQALYAL FAGTDNNLLA
     LQSGCFSYFQ MGGECIEGPV GLLSGLNRSR STLIYHFYRV AFHSIWLLFH NASSVAEFPL
     LFLRALSIFW TACLDLILFP GDAELISVPQ CTTGRVVVLQ FKTSSQRNFF WLQEASTARD
     QFILEQVNTL IHTQEDEEEY LDEDAIMEGA EESAGTSTTT GATEASIAPS AAFAPAAPVS
     SSAAQPAGAA GGSSLTSQQM DQLRHLLGGI QVPQTTGGVA RQSNLRLDHV LTPGAAASLL
     SNPQICQALF PHLPESSERT PEEIQAIVRT PQFSQALVSL STALGSGQLG PLLRQFGLGP
     NAGDGVEGFL AAIEEQAKKE KK
//