ID A0A9P9FEP8_9HYPO Unreviewed; 553 AA.
AC A0A9P9FEP8;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=Arginase {ECO:0000256|ARBA:ARBA00018123};
DE EC=3.5.3.1 {ECO:0000256|ARBA:ARBA00012168};
GN ORFNames=B0J13DRAFT_580836 {ECO:0000313|EMBL:KAH7159588.1};
OS Dactylonectria estremocensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Dactylonectria.
OX NCBI_TaxID=1079267 {ECO:0000313|EMBL:KAH7159588.1, ECO:0000313|Proteomes:UP000717696};
RN [1] {ECO:0000313|EMBL:KAH7159588.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MPI-CAGE-AT-0021 {ECO:0000313|EMBL:KAH7159588.1};
RA Mesny F., Miyauchi S., Thiergart T., Pickel B., Atanasova L., Karlsson M.,
RA Huettel B., Barry K.W., Haridas S., Chen C., Bauer D., Andreopoulos W.,
RA Pangilinan J., LaButti K., Riley R., Lipzen A., Clum A., Drula E.,
RA Henrissat B., Kohler A., Grigoriev I.V., Martin F.M., Hacquard S.;
RT "Genetic determinants of endophytism in the Arabidopsis root mycobiome.";
RL Nat. Commun. 0:0-0(2021).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine + H2O = urea + L-ornithine; Xref=Rhea:RHEA:20569,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:46911; EC=3.5.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00047391};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-
CC arginine: step 1/1. {ECO:0000256|ARBA:ARBA00005098}.
CC -!- SIMILARITY: Belongs to the arginase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00742, ECO:0000256|RuleBase:RU003684}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH7159588.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAGMUU010000002; KAH7159588.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9P9FEP8; -.
DR OrthoDB; 9992747at2759; -.
DR Proteomes; UP000717696; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0004053; F:arginase activity; IEA:UniProtKB-EC.
DR GO; GO:0030145; F:manganese ion binding; IEA:TreeGrafter.
DR GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09989; Arginase; 1.
DR FunFam; 3.40.800.10:FF:000012; Arginase; 1.
DR Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR InterPro; IPR014033; Arginase.
DR InterPro; IPR006035; Ureohydrolase.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR InterPro; IPR020855; Ureohydrolase_Mn_BS.
DR NCBIfam; TIGR01229; rocF_arginase; 1.
DR PANTHER; PTHR43782; ARGINASE; 1.
DR PANTHER; PTHR43782:SF3; ARGINASE; 1.
DR Pfam; PF00491; Arginase; 1.
DR PRINTS; PR00116; ARGINASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR PROSITE; PS01053; ARGINASE_1; 1.
DR PROSITE; PS51409; ARGINASE_2; 1.
PE 3: Inferred from homology;
KW Arginine metabolism {ECO:0000256|ARBA:ARBA00022503};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003684};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000717696};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 392..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 553 AA; 61166 MW; 05409403309602F2 CRC64;
MNTGVVQSRF LSKPDELGVV AVGFSGGQTK DGVDDGPAVL IESGLLDQVK EELGYKIFGD
QTVQQFQDLI PASDPDFRGM KKALHASAVT RSIANQTYEQ SVQGRMVLTL GGDHSIAIGT
IAGTAKATRE LHNREIAVIW VDAHTDINTP ESSDSGNIHG MPVAFLTGLA KEENEEYFGW
IKDDMRISVK KIVYIGLRSV DIPERKILRE NGIKAFSMFD IDRHGIGRVM EMALGHIGTD
TPIHLSFDVD ALDPMWAPST GTPVRGGLTL REGDYICESV HQTGNLVAVD LVEVNPKLVT
AEDIGANETI RAGCSLVRTT RIPQEKKNWV LILDCEDVIL SPSDINFSPT IYTPSITMVA
RSSYTAGGSS MTYDQSRVIS HVRTYNWPPL QLNFWIFVML LCSCSIIGVF SIFIQTQNQL
LLPIPWYFPY LITVAALAIF FVAIIFYLIA QRRLLPAIVM IGAFMLFILW LVGLVVVGIQ
LFGPEKSINS VCSIEVFGRN PTGQNEETMA WLQQRNILSE IGQSWQLVFA MSLTGVIFQI
WVMVMSYQVF ANS
//
