ID A0A9P9KG14_FUSSL Unreviewed; 441 AA.
AC A0A9P9KG14;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 10-JUN-2026, entry version 12.
DE RecName: Full=Prephenate dehydrogenase [NADP(+)] {ECO:0000256|PIRNR:PIRNR036510};
DE Short=PRDH {ECO:0000256|PIRNR:PIRNR036510};
DE EC=1.3.1.13 {ECO:0000256|PIRNR:PIRNR036510};
GN ORFNames=B0J15DRAFT_492025 {ECO:0000313|EMBL:KAH7260188.1};
OS Fusarium solani (Filamentous fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium solani species complex.
OX NCBI_TaxID=169388 {ECO:0000313|EMBL:KAH7260188.1, ECO:0000313|Proteomes:UP000736672};
RN [1] {ECO:0000313|EMBL:KAH7260188.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FSSC 5 MPI-SDFR-AT-0091 {ECO:0000313|EMBL:KAH7260188.1};
RA Mesny F., Miyauchi S., Thiergart T., Pickel B., Atanasova L., Karlsson M.,
RA Huettel B., Barry K.W., Haridas S., Chen C., Bauer D., Andreopoulos W.,
RA Pangilinan J., LaButti K., Riley R., Lipzen A., Clum A., Drula E.,
RA Henrissat B., Kohler A., Grigoriev I.V., Martin F.M., Hacquard S.;
RT "Genetic determinants of endophytism in the Arabidopsis root mycobiome.";
RL Nat. Commun. 0:0-0(2021).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADPH; Xref=Rhea:RHEA:21640, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.13;
CC Evidence={ECO:0000256|ARBA:ARBA00051295,
CC ECO:0000256|PIRNR:PIRNR036510};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00060605, ECO:0000256|PIRNR:PIRNR036510}.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007964, ECO:0000256|PIRNR:PIRNR036510}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH7260188.1}.
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DR EMBL; JAGTJS010000008; KAH7260188.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9P9KG14; -.
DR OrthoDB; 5399569at2759; -.
DR Proteomes; UP000736672; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:TreeGrafter.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:UniProtKB-UniRule.
DR FunFam; 1.10.3660.10:FF:000002; Prephenate dehydrogenase [NADP(+)]; 1.
DR FunFam; 1.10.3660.10:FF:000004; Prephenate dehydrogenase [NADP(+)]; 1.
DR FunFam; 3.40.50.720:FF:000339; Prephenate dehydrogenase [NADP(+)]; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR050812; Preph/Arog_dehydrog.
DR InterPro; IPR003099; Prephen_DH.
DR InterPro; IPR012385; Prephenate_DH_fun.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF27505; 6PGD_Tyr1_C; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR Pfam; PF20463; PDH_C; 1.
DR PIRSF; PIRSF036510; PDH_fung; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141,
KW ECO:0000256|PIRNR:PIRNR036510};
KW NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|PIRNR:PIRNR036510};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Reference proteome {ECO:0000313|Proteomes:UP000736672};
KW Tyrosine biosynthesis {ECO:0000256|ARBA:ARBA00022498,
KW ECO:0000256|PIRNR:PIRNR036510}.
FT DOMAIN 15..296
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 441 AA; 49612 MW; D83B2C39AD52C6CE CRC64;
MASQVQPIPE GMENFVVGLI GMGDMGKMYA ERLSAAGWRI LACDREENLE SLQKEYAGNK
NIEICRNGHL VSRASDYIIY SVEAAVIDRV IAQYGPSTKL GAIVGGQTSC KSPEIAAFEA
HLPADVSIVS CHSLHGPNVD PYNQPLVLIQ HRAPDEALAK VEAVLSCLRS KFVYLSAREH
DRITADTQAV THAAFLSMGK AWHANRQFPW ELSRYVGGIE NVKVNIMLRI YSQKWHVYAG
LAILNPEARE QIAQYARSVT DLYKLMLEGN FEGLRDRVYQ ARDKVFGPST TWGNRPLLEP
SILSSFSLGT PTDEPRPNNH LSLLAMVDCW AALNIVPYDH MLCSTPLFRL RLGVTEYLFR
NGDVLDAAIR TAIEDKTYRS DDLEFTFAAR AWAECVSLGH FETWEKRFVS TQEFFEPRFE
EAKVVGNQMM KKVLESLRDE N
//
