ID A0A9P9Z1Q9_9MUSC Unreviewed; 682 AA.
AC A0A9P9Z1Q9;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=BBSome complex member BBS5 {ECO:0000256|ARBA:ARBA00047191};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=M5D96_002862 {ECO:0000313|EMBL:KAI8046649.1};
OS Drosophila gunungcola (fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=103775 {ECO:0000313|EMBL:KAI8046649.1, ECO:0000313|Proteomes:UP001059596};
RN [1] {ECO:0000313|EMBL:KAI8046649.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sukarami {ECO:0000313|EMBL:KAI8046649.1};
RX PubMed=36930539; DOI=10.1093/gbe/evad048;
RA Negi A., Liao B.Y., Yeh S.D.;
RT "Long-read-based Genome Assembly of Drosophila gunungcola Reveals Fewer
RT Chemosensory Genes in Flower-breeding Species.";
RL Genome Biol. Evol. 15:evad048-evad048(2023).
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00004823}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the BBS5 family.
CC {ECO:0000256|ARBA:ARBA00005822}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAI8046649.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAMKOV010000001; KAI8046649.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9P9Z1Q9; -.
DR Proteomes; UP001059596; Chromosome 3R.
DR GO; GO:0034464; C:BBSome; IEA:InterPro.
DR GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:InterPro.
DR CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.550.10; Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A; 2.
DR InterPro; IPR006606; BBL5.
DR InterPro; IPR014003; BBS5_PH.
DR InterPro; IPR056729; GMPPB_C.
DR InterPro; IPR045233; GMPPB_N.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR Pfam; PF07289; BBL5; 1.
DR Pfam; PF25087; GMPPB_C; 1.
DR Pfam; PF00483; NTP_transferase; 2.
DR SMART; SM00683; DM16; 2.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP001059596}.
FT DOMAIN 336..390
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
FT DOMAIN 472..526
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
SQ SEQUENCE 682 AA; 76059 MW; 9A2F7F22E76FF347 CRC64;
MCGNPAVGNG TRALILVGGY GTRLRPLTLS TPKPLVEFAN KPILLHQLEA LVDAGCRQVI
LAVSYRAEQM EKELKVEADK LGVELIFSHE TEPLGTAGPL ALAKNILTAS SEPFFVLNSD
VICDFPFKQL NGCIKNFIEK PQEFVSNKIN AGIYIFNPSV LDRIEVKPTS IEKEVFPAMA
QQQELYAMDL TGFWMDIGQP KDFLTGMCLY LSSLRQKQSP KLYTGPGVVG NVLVDPTAKI
GEGCRIGPNV TIGPDVVIED GGAIVRSHSW LDSCIVGWRS TVGRWVRIEG ITVLGEDVIV
KDELYVNGGQ VLPHKSIAAS VPEPQIIMHK NLRSGERVLD YIYHIEDSKG NPGDTGRLMV
TNLRIIWHSL VHKKYNLSIG YARICNTNTR IVHMHAKARI ASQALYILAI SNETRFEFLF
TDVSGETSRR DQPIFASVFD VYHLYQRTYL YRDLKLRGAI VQSGQLVILP DEQVYSQVQG
VWNLSSDQGN LGSFVVSNIR LVWFADANET FNISLPYLQI ESLRVRESKY GPALVIQTAE
TGGGYVLGFR VDPAERLNEL FKELCSLHTI YGEQPNFGIQ YNAQDARQRL AEAAEEAAQA
SQFKVDNFEE LDERQEREIN TKLNSYLAEG CLGKLASGSG SGQEEKVPVY CKELGFAMEQ
IKDGYKLQDL WNVMPTKMET ME
//
