ID A0A9Q0DRI8_9TELE Unreviewed; 409 AA.
AC A0A9Q0DRI8;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Suppressor of cytokine signaling 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=NHX12_005540 {ECO:0000313|EMBL:KAJ3593204.1};
OS Muraenolepis orangiensis (Patagonian moray cod).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Zeiogadaria; Gadariae; Gadiformes; Muraenolepidoidei; Muraenolepididae;
OC Muraenolepis.
OX NCBI_TaxID=630683 {ECO:0000313|EMBL:KAJ3593204.1, ECO:0000313|Proteomes:UP001148018};
RN [1] {ECO:0000313|EMBL:KAJ3593204.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KU_S4_2022 {ECO:0000313|EMBL:KAJ3593204.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAJ3593204.1};
RA Kim J.;
RT "Chromosome-level genome of Muraenolepis orangiensis.";
RL Submitted (JUL-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ3593204.1}.
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DR EMBL; JANIIK010000112; KAJ3593204.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9Q0DRI8; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP001148018; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001148018};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 258..353
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 348..397
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..58
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 46296 MW; 27909BD2924F2444 CRC64;
MSEKKPRGSG TRPKSGIRSW SADSYVWRGK KRSRSSQNEP VFQGQAAEEA EEEEEAGEQE
LGGRSTSCPR WRRERKCSCS TLGGEADGEM TCRRSVSRRS LRQKFTDAVG QCLPLRSHHH
HHHHHLHNHH HQPLTPGSSR PFSVLLWSKR KIHVSELMQD KCPFSPKSEL AHCWHLIKKH
TPHPSAFKGP EAPHKSLASS SSCSPPPTPL SWEDICCSPG TGSGSLEDWD PSCPHGAAGG
HTDYILVPDL LQINNSPCYW GVLNRFEAEE LLEGQPEGTF LLRDSAQDEF LFSVSFRRYS
RSLHARIEQS DKRFSFDGRD PCMYRDPSVT GLLRHYSDPA SCLFFEPLLS RPLPRNFPFS
LQHLCRAVVC SCTTYRGIHG LPLPPQLRDF LKQYHFKSDA ACSMNIEKH
//
