ID A0A9Q0EJH4_9TELE Unreviewed; 599 AA.
AC A0A9Q0EJH4;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=Forkhead box protein K2 {ECO:0000256|ARBA:ARBA00072763};
DE AltName: Full=Interleukin enhancer-binding factor 1 {ECO:0000256|ARBA:ARBA00082763};
GN ORFNames=NHX12_025074 {ECO:0000313|EMBL:KAJ3608024.1};
OS Muraenolepis orangiensis (Patagonian moray cod).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Zeiogadaria; Gadariae; Gadiformes; Muraenolepidoidei; Muraenolepididae;
OC Muraenolepis.
OX NCBI_TaxID=630683 {ECO:0000313|EMBL:KAJ3608024.1, ECO:0000313|Proteomes:UP001148018};
RN [1] {ECO:0000313|EMBL:KAJ3608024.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KU_S4_2022 {ECO:0000313|EMBL:KAJ3608024.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAJ3608024.1};
RA Kim J.;
RT "Chromosome-level genome of Muraenolepis orangiensis.";
RL Submitted (JUL-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-
CC ProRule:PRU00089}.
CC -!- SIMILARITY: Belongs to the FOXJ1 family.
CC {ECO:0000256|ARBA:ARBA00034770}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ3608024.1}.
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DR EMBL; JANIIK010000040; KAJ3608024.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9Q0EJH4; -.
DR OrthoDB; 691130at2759; -.
DR Proteomes; UP001148018; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0060271; P:cilium assembly; IEA:UniProtKB-ARBA.
DR GO; GO:0003146; P:heart jogging; IEA:UniProtKB-ARBA.
DR GO; GO:0001947; P:heart looping; IEA:UniProtKB-ARBA.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR CDD; cd20055; FH_FOXK2; 1.
DR FunFam; 1.10.10.10:FF:000030; Forkhead box protein K2; 1.
DR FunFam; 2.60.200.20:FF:000025; Forkhead box protein K2; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047397; FH_FOXK2.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45881; CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR45881:SF3; FORKHEAD BOX PROTEIN K2; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP001148018};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 24..84
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 213..308
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 213..308
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 114..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 63945 MW; F72B82CAA5BF9C01 CRC64;
MALGPALARL EGREFEYVMK KRSVTVGRNS SQGSVDLSMG HSSFISRRHL ELFTAGGEDG
GPGGGDFYLR CLGKNGVFVD GVFQRRGAPP LQLPRMCCLR FPSTSIKITF TALSPERKEK
ERRNAPESPL KVQPPIAPLT INIPDNMAHL MSPLPSPTGT LSAANSCPSS PRGAGLSSYR
MGRVLTSDLM GDNSQSENDK EASGGDSPKD DSKPPYSYAQ LIVQAITMAL DKQLTLNGIY
THITKNYPYY RTADKGWQNS IRHNLSLNRY FLKVARSQEE PGKGSFWRID PSSEGKLIEQ
AFRKRRPRGG PCFRTPLGPL SSRSAPASPN HTGALSAHSS GVQTPDSLSR EGSPVPMEAD
HVSPPAPMAL PIQPKLAVIQ EARFSQNPAG SPLSSQPVLI AVQRQLPQST MKSVTYAVAT
PAMVTTAVNS APVMQTVHVL HQIPVTVATV TKQAPGVVMS GGVGENQQEL KVKVEAVPSV
TAASIGGRII QTSQATPLAT VTIVQPAVLG QHQLPVKTLM QNGTHLLPAM TTAVSNPLHL
LATHASASAS LPTKRPNGEL QPPDPKKLKT EGGGEGEEHN NGRDHHHDDG GVRGQTAAN
//
