ID A0A9Q0XZS0_9SAUR Unreviewed; 564 AA.
AC A0A9Q0XZS0;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=YTH domain-containing family protein {ECO:0000256|RuleBase:RU369095};
GN ORFNames=JRQ81_014322 {ECO:0000313|EMBL:KAJ7332142.1};
OS Phrynocephalus forsythii.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Acrodonta; Agamidae; Agaminae; Phrynocephalus.
OX NCBI_TaxID=171643 {ECO:0000313|EMBL:KAJ7332142.1, ECO:0000313|Proteomes:UP001142489};
RN [1] {ECO:0000313|EMBL:KAJ7332142.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Muscle {ECO:0000313|EMBL:KAJ7332142.1};
RX PubMed=36882113;
RA Qi Y., Zhao W., Zhao Y., Niu C., Cao S., Zhang Y.;
RT "Chromosome-level genome assembly of Phrynocephalus forsythii using third-
RT generation DNA sequencing and Hi-C analysis.";
RL DNA Res. 0:0-0(2023).
CC -!- FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-
CC containing RNAs, and regulates mRNA stability. M6A is a modification
CC present at internal sites of mRNAs and some non-coding RNAs and plays a
CC role in mRNA stability and processing. {ECO:0000256|RuleBase:RU369095}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}. Cytoplasm, Stress granule
CC {ECO:0000256|ARBA:ARBA00004210}.
CC -!- SIMILARITY: Belongs to the YTHDF family.
CC {ECO:0000256|RuleBase:RU369095}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ7332142.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAPFRF010000005; KAJ7332142.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9Q0XZS0; -.
DR OrthoDB; 306690at2759; -.
DR Proteomes; UP001142489; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0061157; P:mRNA destabilization; IEA:UniProtKB-ARBA.
DR CDD; cd21134; YTH; 1.
DR FunFam; 3.10.590.10:FF:000001; YTH domain family 1, isoform CRA_a; 1.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR InterPro; IPR007275; YTH_domain.
DR InterPro; IPR045168; YTH_prot.
DR PANTHER; PTHR12357:SF65; YTH DOMAIN-CONTAINING FAMILY PROTEIN 1; 1.
DR PANTHER; PTHR12357; YTH YT521-B HOMOLOGY DOMAIN-CONTAINING; 1.
DR Pfam; PF04146; YTH; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR PROSITE; PS50882; YTH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP001142489};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU369095}.
FT DOMAIN 394..528
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..330
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 61413 MW; 86AD2675B3B21FCD CRC64;
MSATSVDPQR PKGQDNKVQN GSLHQKDAVH DNDFEPYLSG QSNQNNSYPS MTDPYLSSYY
PPSIGFPYSL SEAPWSTGGD PPIPYLTTYG QLSNGDHHFM HDAVFGQPGG LGNNIYPHRF
NFFPENPPFS AWGTSGSQGQ QTQNSAYGSS YSYPPSSLGG TIVDGQTGFH NDTLNKAPGM
NSIEQGMVGL KIGGDVTASA VKAVGSVVNS AGMAGALSGN GGSSISLPVS KPTSWAAIAS
KPAKPQPKMK TKSGPVVGAA LPPPPIKHNM DIGTWDNKGP AAKVPTPQQI PSPQSVPQPQ
LIQPIPAQPP PLTQLPYQNP QPPPPPPPPQ NRWVAPRNRN AAFGQSGGTG HENNSPGTTP
ANSIPAGESH PVLEKLKAAH SYNPKDFEWN LKNGRVFIIK SYSEDDIHRS IKYSIWCSTE
HGNKRLDSAF RSMNSKGPVY LLFSVNGSGH FCGVAEMKSS VDYGTSAGVW SQDKWKGKFD
VKWIFVKDVP NNQLRHIRLE NNDNKPVTNS RDTQEVPLEK AKQVLKIIAT YKHTTSIFDD
FSHYEKRQEE EEVVRKERQN RNKQ
//
