ID A0A9Q0Y6Z9_9SAUR Unreviewed; 434 AA.
AC A0A9Q0Y6Z9;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE RecName: Full=Suppressor of cytokine signaling 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=JRQ81_001320 {ECO:0000313|EMBL:KAJ7345370.1};
OS Phrynocephalus forsythii.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Acrodonta; Agamidae; Agaminae; Phrynocephalus.
OX NCBI_TaxID=171643 {ECO:0000313|EMBL:KAJ7345370.1, ECO:0000313|Proteomes:UP001142489};
RN [1] {ECO:0000313|EMBL:KAJ7345370.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Muscle {ECO:0000313|EMBL:KAJ7345370.1};
RX PubMed=36882113;
RA Qi Y., Zhao W., Zhao Y., Niu C., Cao S., Zhang Y.;
RT "Chromosome-level genome assembly of Phrynocephalus forsythii using third-
RT generation DNA sequencing and Hi-C analysis.";
RL DNA Res. 0:0-0(2023).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ7345370.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAPFRF010000001; KAJ7345370.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9Q0Y6Z9; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP001142489; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR CDD; cd10385; SH2_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001142489};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 283..378
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 373..422
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..55
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 49377 MW; D3294F2761862F9E CRC64;
MAENKERNPK HSDVRPKNSR SRSADRKDGY VWSGKKLSWT KRSESTTDAE TASTSGKSTL
SLRSQERKHS CSSSELDLER SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHPSVLPPKR
KIHISELMLD KCPFPPRSEL AFRWHLIKRH TAPVKQTSGS WLSVESPTSE GMDAEPRGLE
SAVDKGGSTV SQTCPTGDDV SCQCDPRGEL ALGRQLKSSQ EDSDMDSDED VVTLCTSSWK
RSKSRWETED ELLQLETPLR YHTQIDYVHC LVPDLLQINN NPCYWGVMDK YAAEALLDGK
PEGTFLLRDS AQEDYLFSVS FRRYSRSLHA RIEQWNHHFS FDAHDPCVFH SPDITGLLEH
YKDPSSCMFF EPLLSTPLSR TFPFSLQHIC RTVICNCTTY DGIDALPVPP SVKLYLKEYH
YKSKVRVLRI DVPE
//
