ID A0A9Q1BN35_HOLLE Unreviewed; 177 AA.
AC A0A9Q1BN35;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 6.
DE SubName: Full=Retroviral-like aspartic protease 1 {ECO:0000313|EMBL:KAJ8029696.1};
GN ORFNames=HOLleu_29156 {ECO:0000313|EMBL:KAJ8029696.1};
OS Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria
OS leucospilota).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Holothuriidae; Holothuria.
OX NCBI_TaxID=206669 {ECO:0000313|EMBL:KAJ8029696.1, ECO:0000313|Proteomes:UP001152320};
RN [1] {ECO:0000313|EMBL:KAJ8029696.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nanhai2018 {ECO:0000313|EMBL:KAJ8029696.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAJ8029696.1};
RA Chen T.;
RT "Tropical sea cucumber genome reveals ecological adaptation and Cuvierian
RT tubules defense mechanism.";
RL Submitted (OCT-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ8029696.1}.
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DR EMBL; JAIZAY010000014; KAJ8029696.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9Q1BN35; -.
DR OrthoDB; 10060349at2759; -.
DR Proteomes; UP001152320; Chromosome 14.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00303; retropepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR Pfam; PF13650; Asp_protease_2; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000313|EMBL:KAJ8029696.1};
KW Reference proteome {ECO:0000313|Proteomes:UP001152320}.
FT DOMAIN 31..45
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
SQ SEQUENCE 177 AA; 19331 MW; 91D28DCDA561F469 CRC64;
MPVKPSLSWG RLGSVGAKGL YVRGELDGVE VEFLVDTGAD LTVIQTSLYE RLSERRNVSL
QEVSEDMTVA DGRPLPFKGR GKFQLKVDEL EVVHEVFVAE IDIDAILGYN FLRKYNCTVD
AGRGTVTDGS TQQATVHDET DSRKVVVART VVVPHGSEQM VAGRIRDGPL SSDLVVV
//
