ID   A0A9Q1C0S6_HOLLE        Unreviewed;       246 AA.
AC   A0A9Q1C0S6;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   28-JAN-2026, entry version 8.
DE   SubName: Full=Protein lifeguard 1 {ECO:0000313|EMBL:KAJ8036506.1};
GN   ORFNames=HOLleu_20505 {ECO:0000313|EMBL:KAJ8036506.1};
OS   Holothuria leucospilota (Black long sea cucumber) (Mertensiothuria
OS   leucospilota).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Holothuriidae; Holothuria.
OX   NCBI_TaxID=206669 {ECO:0000313|EMBL:KAJ8036506.1, ECO:0000313|Proteomes:UP001152320};
RN   [1] {ECO:0000313|EMBL:KAJ8036506.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Nanhai2018 {ECO:0000313|EMBL:KAJ8036506.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:KAJ8036506.1};
RA   Chen T.;
RT   "Tropical sea cucumber genome reveals ecological adaptation and Cuvierian
RT   tubules defense mechanism.";
RL   Submitted (OCT-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000256|RuleBase:RU004379}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAJ8036506.1}.
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DR   EMBL; JAIZAY010000009; KAJ8036506.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A9Q1C0S6; -.
DR   OrthoDB; 7933078at2759; -.
DR   Proteomes; UP001152320; Chromosome 9.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd10428; LFG_like; 1.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; BAX INHIBITOR-RELATED; 1.
DR   PANTHER; PTHR23291:SF47; TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004379};
KW   Reference proteome {ECO:0000313|Proteomes:UP001152320};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU004379};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU004379}.
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        72..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        100..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        125..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        159..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        183..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        220..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
SQ   SEQUENCE   246 AA;  27363 MW;  AC602A3A68BAF003 CRC64;
     MAQEKEYRTM SYEDGGGGGG FTFEDVNVKH GFLRKVYGTL TLQLIITVGI IIAIYIPVSE
     HPYTNYFYQN PWVFWTAFGV TFVMIIAMGC VPDLRRKSPI NIICLLLFTA AEGVLLGITC
     STYDAQTVLI AAGACAGIVL LLTLFAFQTK IDFTMMHGVA FVLLMVLLFF GLFAIIFRSD
     VLDVVYCALG VGLFSLYIVI DTQLMIGGKH QYEISEEEYI FAALNLYLDI IQLFLFLLRI
     VGAASD
//