ID A0A9Q1ELF9_SYNKA Unreviewed; 650 AA.
AC A0A9Q1ELF9;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Suppressor of cytokine signaling 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=SKAU_G00331760 {ECO:0000313|EMBL:KAJ8340885.1};
OS Synaphobranchus kaupii (Kaup's arrowtooth eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Synaphobranchidae;
OC Synaphobranchus.
OX NCBI_TaxID=118154 {ECO:0000313|EMBL:KAJ8340885.1, ECO:0000313|Proteomes:UP001152622};
RN [1] {ECO:0000313|EMBL:KAJ8340885.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WJC10195 {ECO:0000313|EMBL:KAJ8340885.1};
RX PubMed=36758078;
RA Parey E., Louis A., Montfort J., Bouchez O., Roques C., Iampietro C.,
RA Lluch J., Castinel A., Donnadieu C., Desvignes T., Floi Bucao C.,
RA Jouanno E., Wen M., Mejri S., Dirks R., Jansen H., Henkel C., Chen W.J.,
RA Zahm M., Cabau C., Klopp C., Thompson A.W., Robinson-Rechavi M.,
RA Braasch I., Lecointre G., Bobe J., Postlethwait J.H., Berthelot C.,
RA Roest Crollius H., Guiguen Y.;
RT "Genome structures resolve the early diversification of teleost fishes.";
RL Science 379:572-575(2023).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ8340885.1}.
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DR EMBL; JAINUF010000015; KAJ8340885.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9Q1ELF9; -.
DR OrthoDB; 8820570at2759; -.
DR Proteomes; UP001152622; Chromosome 15.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001152622};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 397..492
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 487..536
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 97..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 70953 MW; 96ADDA80E38DB85D CRC64;
MEKVGKMWSD LKSRCQTLFH SEGAGRGDGG PEVSDVRCAV DPGRGCRLGE PLSSRAASPA
RSLSPLSLMA DAPQASGRRG HNCVTDIPQI VEITIDKDAE DPRGPGAAPL ARRDSYSRHA
PWGGKKKHSC STKTQSSLET DRRAGRARGA LPRRERRYDA DPCPGRSLRQ RIHDTVGLCL
PLRPRPRPSK ALFTSKRKIH LTELMLETCP FPPGSDLAHK WHLIKQHTAP VSPQSSGTLL
DAFDPARPSP EDEEERLRER RRLSIEEGVD PPPNAQIHTF EATAQVTSLY KLGPKMAPVM
GEGSGEGKGG CGQGGAVAAG AVALATAVVV AAAAPQPVDC DSEEDSTTLC LQSRRPKQRH
TSGDGHPGRQ GPWKVHTQID YIHCLVPDLL QITGLPCYWG VMDRYEAEAL LEGRPEGTFL
LRDSAQEDYL FSVSFRRYNR SLHARIERWN HNFSFDAHDP CVFHASTVTG LLEHYKDPSS
CMFFEPLLTA PLHRTFPFSL QHLARAAICR CTTYDGIGGL PLPSALQDFL KEYHYKQKVP
RALAGERAPK DQIETGWGGG VVGGVSIAQS AGGQEDYKAK TKLRSVHTCS SPADCSVWAF
IFGGEAAAFQ SSAPPRVRRR GSGDWLCVQP AGPTGAEKCL FRIPRSRPLS
//
