ID   A0A9Q1F6G4_SYNKA        Unreviewed;       345 AA.
AC   A0A9Q1F6G4;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   28-JAN-2026, entry version 8.
DE   RecName: Full=Bardet-Biedl syndrome 5 protein homolog {ECO:0000256|PIRNR:PIRNR010072};
GN   ORFNames=SKAU_G00234210 {ECO:0000313|EMBL:KAJ8351945.1};
OS   Synaphobranchus kaupii (Kaup's arrowtooth eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Synaphobranchidae;
OC   Synaphobranchus.
OX   NCBI_TaxID=118154 {ECO:0000313|EMBL:KAJ8351945.1, ECO:0000313|Proteomes:UP001152622};
RN   [1] {ECO:0000313|EMBL:KAJ8351945.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WJC10195 {ECO:0000313|EMBL:KAJ8351945.1};
RX   PubMed=36758078;
RA   Parey E., Louis A., Montfort J., Bouchez O., Roques C., Iampietro C.,
RA   Lluch J., Castinel A., Donnadieu C., Desvignes T., Floi Bucao C.,
RA   Jouanno E., Wen M., Mejri S., Dirks R., Jansen H., Henkel C., Chen W.J.,
RA   Zahm M., Cabau C., Klopp C., Thompson A.W., Robinson-Rechavi M.,
RA   Braasch I., Lecointre G., Bobe J., Postlethwait J.H., Berthelot C.,
RA   Roest Crollius H., Guiguen Y.;
RT   "Genome structures resolve the early diversification of teleost fishes.";
RL   Science 379:572-575(2023).
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000256|PIRNR:PIRNR010072}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309, ECO:0000256|PIRNR:PIRNR010072}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family. {ECO:0000256|ARBA:ARBA00005822,
CC       ECO:0000256|PIRNR:PIRNR010072}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAJ8351945.1}.
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DR   EMBL; JAINUF010000008; KAJ8351945.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A9Q1F6G4; -.
DR   OrthoDB; 10261999at2759; -.
DR   Proteomes; UP001152622; Chromosome 8.
DR   GO; GO:0034464; C:BBSome; IEA:UniProtKB-UniRule.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR   GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR   FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; BBS5_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR010072};
KW   Reference proteome {ECO:0000313|Proteomes:UP001152622}.
FT   DOMAIN          31..85
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          161..215
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   345 AA;  39203 MW;  843ACC8D5FCE2F9F CRC64;
     MTMASVLDAL WEDRDVRFDI SPQQLKMRPG EVLIDCLDSI EDTKGNNGDR GRLLVTSLRI
     MWHSLALPRV NLSVGYNSII NITTRTANSK LRGQTEALYI LTKCLNTRFE FIFTNVVPGS
     PRLFTSVIAV HRAYETSKMY RDLKLRGALI QNKQLRLLPQ EQVYDKINGV WNLSSDQGNL
     GTFFITNVRI VWHANMNESF NVSIPYLQIR SIRIRDSKFG LALVIESSQQ TGGYVLGFKI
     DPMEKLQDAV KEINSLHKVY SASPIFGVDY EMEEKPQPLE ELTVQQLPDD VEIEPDEQTD
     AFTAYIADGT KQQDREPVFS EELGIAIETL KEGFTLQGLW EVMGC
//