ID A0A9Q1HML2_CONCO Unreviewed; 2804 AA.
AC A0A9Q1HML2;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE RecName: Full=Fibrillin-1 {ECO:0000256|ARBA:ARBA00069509};
GN ORFNames=COCON_G00217490 {ECO:0000313|EMBL:KAJ8252437.1};
OS Conger conger (Conger eel) (Muraena conger).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Congridae; Conger.
OX NCBI_TaxID=82655 {ECO:0000313|EMBL:KAJ8252437.1, ECO:0000313|Proteomes:UP001152803};
RN [1] {ECO:0000313|EMBL:KAJ8252437.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Concon-B {ECO:0000313|EMBL:KAJ8252437.1};
RX PubMed=36758078;
RA Parey E., Louis A., Montfort J., Bouchez O., Roques C., Iampietro C.,
RA Lluch J., Castinel A., Donnadieu C., Desvignes T., Floi Bucao C.,
RA Jouanno E., Wen M., Mejri S., Dirks R., Jansen H., Henkel C., Chen W.J.,
RA Zahm M., Cabau C., Klopp C., Thompson A.W., Robinson-Rechavi M.,
RA Braasch I., Lecointre G., Bobe J., Postlethwait J.H., Berthelot C.,
RA Roest Crollius H., Guiguen Y.;
RT "Genome structures resolve the early diversification of teleost fishes.";
RL Science 379:572-575(2023).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ8252437.1}.
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DR EMBL; JAFJMO010000017; KAJ8252437.1; -; Genomic_DNA.
DR OrthoDB; 4062651at2759; -.
DR Proteomes; UP001152803; Unassembled WGS sequence.
DR GO; GO:0001527; C:microfibril; IEA:UniProtKB-ARBA.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:UniProtKB-ARBA.
DR GO; GO:0048731; P:system development; IEA:UniProtKB-ARBA.
DR CDD; cd00054; EGF_CA; 25.
DR FunFam; 2.10.25.10:FF:000005; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000023; Fibrillin 2; 2.
DR FunFam; 2.10.25.10:FF:000038; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000044; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000049; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000058; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000071; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000086; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000097; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000005; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000007; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000009; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000011; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000133; Fibrillin 3; 1.
DR FunFam; 3.90.290.10:FF:000003; Fibrillin 3; 1.
DR FunFam; 3.90.290.10:FF:000020; Fibrillin-1; 1.
DR FunFam; 2.10.25.10:FF:000003; fibrillin-1 isoform X1; 17.
DR FunFam; 2.10.25.10:FF:000002; Latent-transforming growth factor beta-binding protein 3; 2.
DR FunFam; 2.10.25.10:FF:000014; Latent-transforming growth factor beta-binding protein 3; 4.
DR FunFam; 2.10.25.10:FF:000010; Pro-epidermal growth factor; 2.
DR FunFam; 2.10.25.10:FF:000096; Putative fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000008; Signal peptide, CUB domain, EGF-like 2; 1.
DR Gene3D; 2.10.25.10; Laminin; 46.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR024731; NELL2-like_EGF.
DR InterPro; IPR049883; NOTCH1_EGF-like.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR InterPro; IPR052080; vWF_C/EGF_Fibrillin.
DR PANTHER; PTHR47333:SF5; FIBRILLIN-3; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 3.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 35.
DR Pfam; PF21364; EGF_FBN_1st; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 47.
DR SMART; SM00179; EGF_CA; 44.
DR SUPFAM; SSF57196; EGF/Laminin; 14.
DR SUPFAM; SSF57184; Growth factor receptor domain; 10.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 41.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 31.
DR PROSITE; PS50026; EGF_3; 41.
DR PROSITE; PS01187; EGF_CA; 15.
DR PROSITE; PS51364; TB; 9.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP001152803};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..2804
FT /note="Fibrillin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040106505"
FT DOMAIN 147..179
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 185..228
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 247..288
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 289..330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..388
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 461..500
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 501..542
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 543..583
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 584..624
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 630..682
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 694..735
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 736..777
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 778..817
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 822..861
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 881..922
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 927..978
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 999..1036
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1041..1083
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1084..1125
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1126..1167
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1209..1250
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1251..1288
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1293..1333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1334..1374
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1375..1416
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1417..1453
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1458..1498
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1503..1561
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1578..1619
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1620..1660
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1665..1720
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1736..1777
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1778..1818
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1819..1860
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1861..1896
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1900..1941
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1942..1981
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1982..2023
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2028..2081
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2096..2137
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2138..2177
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2219..2262
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2263..2304
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2309..2362
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2374..2415
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2457..2495
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2496..2538
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2539..2578
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2579..2619
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2620..2658
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 27..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 151..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 169..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 465..475
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 782..792
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1865..1875
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2543..2553
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2624..2634
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2804 AA; 304266 MW; 140F34B8182154B2 CRC64;
MLRGRLQTLA LGLAAVLSLC VAAADGSAED GDTDEQVVPR ASRAKRRGGG PDVLKGPNVC
GSRFSAYCCP GWKTLPGGNQ CIVPICRSSC GDGFCSRPNL CTCPNGQTAP SCGSMSVQHC
SARCMNEGSC VDDRCQCQNG FSGANCGQPV CEMGCLNGGR CIAPNRCACT YGFTGGQCER
DYRTGPCFAS VSNQMCQGQL TGIVCTKALC CATVGKAWGH PCEICPTQPR PCRRGFIPNH
RTGACQDVDE CQAVPGLCRG GNCVNTVGSF ECKCPAGHRF SELTQKCEDV DECTTVPGVC
LVGECANTAG SYFCKCPHGY FTPADGSRCI DVRSGYCYTS LLNGRCANQN SQLLTKMQCC
CDSGRCWSYG LTPEICPARG TVEHHGLCSQ QPQQPHQPHR PQVPVWPDLP QPSIVLPRNL
TTMCEAYRNL CLNGRCVPVP GSYRCQCNMG FKLDLREECI DANECEGNPC NHGECVNTDG
SYFCHCPPGF QSTATRTECR DLDECHANGR ICNNGRCVNT DGSFHCVCNA GFEVSADGRN
CHDQDECRNR NMCMNGMCIN EDGSFKCICK QGYRLDPTGR FCIDIDECET QGICMNGHCI
NTDGSFRCEC MAGLAVGLDG RVCVDTHMRS TCYGGYKQGQ CVRPFFRAVT KSECCCVNAE
YAFGEPCRPC PSLSSAEYSA LCRHGPGRGF DGSDIDECAL DPDICQNGVC ENMPRGYRCN
CNLGFEVDSS GQNCRDIDEC AVNGLLCDKG QCRNTPGSFN CHCPKGYRFD TVTDVCEDID
ECESNPCVNG QCRNNQGSFF CQCPTGSTTD SSGTQCVETT KGTCWLRHIN GRCEVNINGA
TLKSHCCSTL GEAWGSPCSP CTKDPFCTKG YARARGTVCE DVNECEVFPG VCINGKCVNT
DGSFICQCPG GMTADSTGRT CIDLRTEQCY LTHEDERCGA AIPGRHRVDA CCCSVGVAWG
LECDECPQKG SSEYSQLCPR GQGFSHRSDI IIGKTILKDI NECKMIHTLC TNGRCRNTVG
SFRCLCDNGF ALDNYERNCT DIDECRIMPE ACGQGTCVNT PGDFECDCFE GYESGFMMMK
NCMDIDECER NPMLCRGGEC VNTEGSFQCV CPEGHEIAPD GSACLDINEC DLSDTLCRNG
QCVNMIGRYQ CSCDTGYKST EDLLSCVDID ECTIQNGGCD TFCTNSEGSY ECSCQSGYAL
MPDHRSCTDI DECEENADIC DGGQCTNLPG EYQCLCFDGF MAAEDMKTCL DVDECELNQN
ICLNGKCENS KGSFICHCDL GYSVRKGSTG CTDINECEIG AHNCHRQGSC TNTAGSFKCS
CGAGWIGDGI KCTDLDECSN GTHLCNHNAD CKNTMGSYRC VCKEGFTGDG FFCSDSDECA
DNVNLCESGH CLNVPGGYRC ECDMGFIPTA DGKACEDIDE CTFADICVSG RCQNIPGLFR
CECSDGFELD RSGGNCTDIN ECADPTICIS GICVNTPGSY LCNCPPDFEL NPTRVGCVDT
RSGNCYLDVR SRGDISEALE CSNEIGVGVA KASCCCSQGQ AWGNPCEACP KLNSSAYKIL
CPGGEGFRPN PITVIVEDID ECQELPGLCQ GGTCINTFGS FYCQCPRGYV LNEDTRICED
VNECERPGIC GPGQCYNTIG NYTCICPADY MQVNGGNNCL DMRKSLCYRK FYSDNSSCDG
ELASNMTKKM CCCSYNVGRA WNHPCEQCPV PSTTEFVALC GSERVGFTEK DGKIVDIDEC
RDTPSVCQHG VCINMIGSFR CECPMGFVYN DRLLVCEDID ECQNGPVCQQ NAVCVNLPGS
HRCECKPGYR FTPSGQCLDR NECVEIPNVC NPGQCVDTLG SYRCVCPNGY KATADSSMCI
DADECDRQPC GNGTCKNTVG SYRCLCYPGF QLSHNSDCVD HDECASLRGL CRNGDCINTV
GSFFCFCRDG FELTPDGRTC VDINECLVNP GTCGPGTCQN LDGSYRCICP AGYYLVDETC
EDVDECSQTP DLCTFGTCTN TEGSFKCVCP PGFKLSSSGR RCNDVRVNYC FSKFENGVCQ
SAQPSNTTKA RCCCSMLPGQ GWGNPCEICP TMEEEGYNLL CSGTGHFTRP DGETIDIDEC
ADHPGVCKNG QCINTDGSFR CECSFGFRLD FTGINCEDIN ECGLGNPCGN GTCTNVVGAF
ECTCDEGYEP GPMMTCEDVN ECSQNPLLCA FRCVNTEGSY ECKCPTGYVL RDDGRMCKDQ
DECEEGIHDC DSKGMTCKNL IGTFMCICSP GYIPQPSRDR CMDLNECSAK PGICVNGRCQ
NIIGSYRCSC NDGFIANPTQ TECIDNRQGF CFTEVLQTLC QKSSSSRVSV SKSECCCNSG
RGWGPTCELC PLSGTKTFKK LCPLGPGYGI DGKDIDECRI MDNLCRNGQC VNTLGSYNCI
CKPGYTTHIT RTTCVDVDEC TQAPKPCNFI CKNTDGGYQC SCPRGYLLQE DGKSCKDLDE
CATKKHNCQF LCVNTIGSFT CKCPPGFSQH HTTCIDNNEC TADPGVCGSN GVCQNSPGTY
RCECQRGFSM DPGGHSCEDT DECDGTHHCQ HGCQNMVGGY RCNCPQGYLQ HYQWNQCVDE
NECQSSQVCG EANCHNTLGS FRCVCPAGFD FQQHGSGCQD VNECSSQNPC SHGCSNTNGG
YLCACPRVLQ GRARALCLRK GRTRRSTNGT EEPHTHSQNE QETISLASVD IDDTLLLSFN
ISDLNHKQHL LEFIPALSTL TDHVLYAIEL GNDDGLFKIN HRDGVSYLHL TKKKVLPGAY
YLQIGSVPLY RKEEIARLEE ENTKDYLTGQ LGDALKMKVQ IVLH
//
