ID A0A9R1SKB9_CYPCA Unreviewed; 384 AA.
AC A0A9R1SKB9;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE SubName: Full=Forkhead box I3a {ECO:0000313|Ensembl:ENSCCRP00000096067.2};
OS Cyprinus carpio carpio.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=630221 {ECO:0000313|Ensembl:ENSCCRP00000096067.2, ECO:0000313|Proteomes:UP001108240};
RN [1] {ECO:0000313|Ensembl:ENSCCRP00000096067.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSCCRP00000096067.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A9R1SKB9; -.
DR Ensembl; ENSCCRT00000104256.2; ENSCCRP00000096067.2; ENSCCRG00000051793.2.
DR GeneTree; ENSGT00940000164576; -.
DR OMA; PYGMQRP; -.
DR Proteomes; UP001108240; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:TreeGrafter.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-ARBA.
DR GO; GO:0009888; P:tissue development; IEA:UniProtKB-ARBA.
DR CDD; cd20053; FH_FOXI1; 1.
DR FunFam; 1.10.10.10:FF:000016; Forkhead box protein I1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR050211; FOX_domain-containing.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF383; FORKHEAD BOX I2-RELATED; 1.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP001108240};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 145..239
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 145..239
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 384 AA; 42517 MW; 347EE4E53A9489C8 CRC64;
MHLTNPPVLD RGSRAEGVVF SQNDRTNRRK KKEESMTSFV PHALSPQFHS MGQESQEFSL
YGDNLYSTQP VPSPQQTLPS AYDFGEYAGQ TSNPYLWFNG PGINPAPQHY GMTKPYVATG
GIGGSEGGFS WFSLPSQEDL MKLVRPPYSY SALIAMAIHG APNRRLTLSQ IYQYVADNFP
FYNKSKASWQ NSIRHNLSLN DCFMKVPRDD SDPGKGNYWT LDPNCEKMFD NGNFRRKRKR
KSDSLAEEEG KGYSGSDSAL SSPKEPTDTS ERGNSPVSKD PTPCLSGFLS QMGDVAKGSR
EALLPSPLAL PLSQRSSQTG AYDSYSPNAT VPQWETHIPP PVPSNISTSY TDSYSVSMLN
QYTSQLYPVM GSSDLLYPRE GTEV
//
