ID A0A9R1W2S7_LACSA Unreviewed; 1274 AA.
AC A0A9R1W2S7;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 13.
DE RecName: Full=NB-ARC domains-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LSAT_V11C300148940 {ECO:0000313|EMBL:KAJ0217336.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:KAJ0217336.1, ECO:0000313|Proteomes:UP000235145};
RN [1] {ECO:0000313|EMBL:KAJ0217336.1, ECO:0000313|Proteomes:UP000235145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Salinas {ECO:0000313|Proteomes:UP000235145};
RC TISSUE=Seedlings {ECO:0000313|EMBL:KAJ0217336.1};
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ0217336.1}.
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DR EMBL; NBSK02000003; KAJ0217336.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9R1W2S7; -.
DR OrthoDB; 1759104at2759; -.
DR Proteomes; UP000235145; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-ARBA.
DR FunFam; 3.40.50.300:FF:001091; Probable disease resistance protein At1g61300; 1.
DR FunFam; 1.10.10.10:FF:000322; Probable disease resistance protein At1g63360; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR055414; LRR_R13L4/SHOC2-like.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR058922; WHD_DRP.
DR PANTHER; PTHR36766:SF61; NB-ARC DOMAIN DISEASE RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF23598; LRR_14; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR Pfam; PF23559; WHD_DRP; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000235145};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..94
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 170..348
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 434..502
FT /note="Disease resistance protein winged helix"
FT /evidence="ECO:0000259|Pfam:PF23559"
FT DOMAIN 567..892
FT /note="Disease resistance R13L4/SHOC-2-like LRR"
FT /evidence="ECO:0000259|Pfam:PF23598"
FT COILED 28..55
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1274 AA; 144085 MW; 1A2DF632348BDA94 CRC64;
MAEIVLSAFL TVVFEKLASE ALKKIVRSKG IESELKKLKK TLDQIQDLLN DASQKEVTNE
AVKRWLNDLQ HLAYDIDDLL DDLATEAIHR ELTEEGGAST SVVRKLIPSC CTSFSQSNRM
HAKLDDIATR LQELVEAKNN LGLSVITYEK PKIERYEASL VDESGIVGRE DDKKKLLEKL
LGDKDESGSQ NFSIVPIVGM GGVGKTTLAR LLYDEKKVKD HFELRAWVCV SDEFSVTNIS
RVIYQSVTGE NKEFADLNLL QEALKKKLQN KLFLIVLDDI WSESYGDWEK LVGPFHAGTS
GSRIIMTTRK EQLLKQLGFS HEDPLHSIDS LQRLSQEDAL SLFSQHAFGV PNFDSHPTLR
PYGEQFVKKC GGLPLALRIL GRLLRTKTDE EEWKSLLDSE IWSLGNEDKI VPVLRLSYND
LSATLKLLFA YCSLFPKDYV FDKEELVLLW MAEGFLQHSA ARNSMQQWGQ KCFEELLSRS
FFQHAPHDKS LFVMHDLLND MATYVAGDFF SRLDIEIKQE FGKEPLKKQR HMSFVCEDYV
VYKRFKPLKG AKSLRTFLAL SVGVVGSWIT FYLSNKVLND LLQELPLLRV LSLTHLTISE
VPEVVGSMKH LRYLNLSWTS ITHLPENVCN LYNLQTLILS SCYKLIKLPE SFSKLKDLQH
FDMMGSFMLK TMPLGIGELK SLHTLSSDIG LKLTELKNLQ NLHGKVCIDG LGNVENSADA
REANFSRKRF SELVLDWGDE FNVLRTKSLE KEILNELMPY NGTLEKLRIS LYRGVEFPNW
VGDPSYRRLT IVSIESCEES TSLPMLGQLP SLKELFIGGM SKVKVVGMEF LGTDLAFPSL
EILEFDSMSG WEEWSTKSGA FPCLQELCIE DCPNLVRVSL EALPSLRVLK LRKCGHGVLK
SLVDIALSIT KLEIDDISGL TDEVWRGMIG CLGAVEEIKI SECNEIRYLW ESEAEASKLL
MNLKMLELRK CENLVSLGEK DKEDNCGSSL TSFSWLGVWN CNSLEHCSCP DSMETLDIWD
CDSITSVSFP TGGGQKLKSL VIWDCKKLSE KELGGKEKTR FLIKSKMQML EFVFIANWPN
LKSISELSCF IHLNRLCISE CPGMESFPDH ELPNLTSLTE LTIKKCTSMD ASFPRGLWPP
KLCRLEIGEL KKPISEWGPQ NFPTSLSHLT LYGGPYDDVK NFAQLSHLLP SSLTSLGIDR
FEKLDSVSTG LQHLTSLQHL FICNCPKTVD LPEKLLSSLL VLRIVKCPNL KEKSCKGGSY
WPLISLIPYL DIDE
//
