ID A0A9W3AQB1_BIOGL Unreviewed; 335 AA.
AC A0A9W3AQB1;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE RecName: Full=Nuclear migration protein nudC {ECO:0000256|ARBA:ARBA00017641};
DE AltName: Full=Nuclear distribution protein C homolog {ECO:0000256|ARBA:ARBA00030427};
GN Name=LOC106070306 {ECO:0000313|RefSeq:XP_055889380.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|Proteomes:UP001165740, ECO:0000313|RefSeq:XP_055889380.1};
RN [1] {ECO:0000313|RefSeq:XP_055889380.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: Plays a role in neurogenesis and neuronal migration.
CC Necessary for correct formation of mitotic spindles and chromosome
CC separation during mitosis. Necessary for cytokinesis and cell
CC proliferation. {ECO:0000256|ARBA:ARBA00046142}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Midbody
CC {ECO:0000256|ARBA:ARBA00004214}.
CC -!- SIMILARITY: Belongs to the nudC family.
CC {ECO:0000256|ARBA:ARBA00010513}.
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DR RefSeq; XP_055889380.1; XM_056033405.1.
DR AlphaFoldDB; A0A9W3AQB1; -.
DR GeneID; 106070306; -.
DR OMA; NQMEWWS; -.
DR OrthoDB; 416217at2759; -.
DR Proteomes; UP001165740; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0051082; F:unfolded protein binding; IEA:TreeGrafter.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IEA:TreeGrafter.
DR CDD; cd06492; p23_mNUDC_like; 1.
DR FunFam; 2.60.40.790:FF:000001; Nuclear migration protein nudC; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR032572; NuDC.
DR InterPro; IPR037898; NudC_fam.
DR InterPro; IPR025934; NudC_N_dom.
DR PANTHER; PTHR12356:SF3; NUCLEAR MIGRATION PROTEIN NUDC; 1.
DR PANTHER; PTHR12356; NUCLEAR MOVEMENT PROTEIN NUDC; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF16273; NuDC; 1.
DR Pfam; PF14050; Nudc_N; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR PROSITE; PS51203; CS; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP001165740}.
FT DOMAIN 171..262
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT REGION 68..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 38453 MW; D26E1DBF339BB28F CRC64;
MSGTADPERF DGMLLAMAQQ CEGGVQELLD VFFGFLARKT DFYTGAGVDP AMKMVIAKFE
QHEKLVAERL KKEKEEKEAE EKRRKERIAK KKAEEEKERS KVEEEPKIKE LTEEEAEQLE
QDLKKEKENS SSNIANGTGD VESKLEKAAS DDEEEDEKDK GKLKPNVGNG ADMANYSWTQ
TLQEVEIKVP FQVGFPLKSR DLVVNIEKKK LCVGLKGHPP VINGTMYNEV KVDESTWCIV
DSKMLLINLE KVNQMEWWSR IVTTEPEINT KKVQPENSKL SDLDGETRSM VEKMMYDQRQ
KELGLPTSDE QKKQDVLKKF MEQHPEMDFS KCKFS
//
