ID A0A9W3HMT7_CAMBA Unreviewed; 3203 AA.
AC A0A9W3HMT7;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 08-OCT-2025, entry version 11.
DE SubName: Full=WD repeat- and FYVE domain-containing protein 4 isoform X2 {ECO:0000313|RefSeq:XP_045378974.1};
GN Name=WDFY4 {ECO:0000313|RefSeq:XP_045378974.1};
OS Camelus bactrianus (Bactrian camel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=9837 {ECO:0000313|Proteomes:UP000694950, ECO:0000313|RefSeq:XP_045378974.1};
RN [1] {ECO:0000313|RefSeq:XP_045378974.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_045378974.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
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DR RefSeq; XP_045378974.1; XM_045523018.1.
DR GeneID; 105075611; -.
DR CTD; 57705; -.
DR Proteomes; UP000694950; Unplaced.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:TreeGrafter.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR FunFam; 1.10.1540.10:FF:000002; WD repeat and FYVE domain containing 3; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR051944; BEACH_domain_protein.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF3; WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000694950};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2388..2513
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2553..2847
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2997..3038
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1841..1873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2319..2350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..980
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1848..1862
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3203 AA; 355797 MW; BF117A3B6DB6D2B7 CRC64;
MEAKDVPKAE DRAEDPGSKN KGQPDVAQPD FPRGGQTPGP TTLWEMLERK FLEYQQQAYR
NPAERQKSLL NLLPLFLKAW EHSVGIICFP SLAKLAEDVS NQLVQEIQKV LVGKPAEQAR
VAAGQFLRWK GDADQDGYLL LKSVYVLTGT DSETLGRVAE SGLPALLLQC LYLFFVFPLE
KDELFESDAP VQRMFVQMLL NLCSDAQGLE GLLSGNELQS LVIATTCLRE HSCSFWKEPT
FCVLKAISKA QNLSIFQYLQ AMDCIKISLQ NLSRLADTLP APEVSEVVSL ILGFVKDSYP
VSSALFLEFE NGEGYPLLLK VLLRYDELTQ SDVDPHLEEL LGLVVWLTTC GRSELKVFDS
VTYPQLEGFK FHHETSGVTV KNLQAFQVLQ NVFHKASDPV LCTKVLLSIK TMWTWNARNF
FLLEWTLQPI SQFVEIVPLK PTPVQVHFFQ LLEALVFEMH YVPHEILRKV QRLIKESPEP
LCTLVALQSV LRIAGADPLF TDIFRDSGLL GLLLAQLRKQ AKILRKSAGN KESSPGVQDT
ERELTCVMLR TVVTLLKGSV RNAVVLKDHG MVPFIKIFLD DECYRGASLS ILEQLSVINA
EEYMSIIVGA LCSSTQGELP LKLDLLKSVL RILETPKGRA AFRVSSGFNG LLSLLSDLEG
SLQDPPLQMW SVVSPSQTLD LVLHTLCALS AALHLDPVNG DFFRRNGLFE KLAEDLCLLG
CFGVLEEESA PLQSWEDMKA RPFADLLSVA FSSASPLPPK IQSCLQILSF LDSMARGTLH
LRRDLKDSPR AMQELVVDAQ RGEANSDPQG NFKQWPDLED RMDDGDAVIM HPGVLCIMVS
LLPRLYHEDH PQLSEEIQCS LASHIQSLVK SEKNRQVMCE AGMLRTLMTS CHKVLTTGSS
PLQSGLIRIF EKLASQAIEP DVLRQFLGLG IPPPPSAAAK ILNSSHVHSG DSGCSGSPAA
APVPAEGPAA AAQDASPCPV VTQASRPSRP SQGSTTALQT ALSLISMTSP RNLQPQRAAL
APSFMEFDMS VEGYGCLFIP TLSTVMGTST EYSISGGIGT GAARSFPPPG GLTFSCWFLI
SRHGAVLEGH PLRFLTLVRH LARTEQPFVC FSVSLCPDDL SLVVSTEEKE FQPLDVMEPE
DDSEPSAGCQ LRVRCGQLLA CGQWHHLTVV VTKEMKRNCM VSTYLDGQVI GSAKMLYIQA
LPGPFLSMDP SSFVDVYGYI ATPRVWKQKS SLIWRLGSAY LFEEAISVET LEVINKLGPR
YCGNFQAVLD QGEDPGMEVT PLVAEERVSF GLHIASSSVT SAADIRTAYN EVDSRLIAKE
MNISSRDNTT PVFLLRNCAG HLSGSLRTIG AVAVGQLGVR VFHSSPAASS LDFIGGPAIL
LGLISLATDD HTMYAAVKVL HSVLTSNVMC DRLMQHICGY QIMAFLLRKK TSFLNHRIFQ
LILSIAGTAE LGFGSSAITN VGVFQHILCN FELWMNAADN LELSLFSHLV EILQSPRDGP
RNAEVAHQTR LIPKLVFHFN EPGLTPSKMP TIIAILGHQL RGHFSLQDLL RIGLFVVYTL
KPSSSVSERP ICVDGAPDPS VPAGSQTSGK TIWLRNQLLE MLLSVISSSQ LHLSSETKEE
MFLNLGPDWF LLFVQAHLHP SSVVLGLKLL LHFLSSPSLR ARFKDGLPAG CWVERSSEGV
DIMMESLQSH PPVPDQSPCL LPGFRVLSDS LAHHVHIPEV YLVVSTFFLQ TPLTELVDRP
KDSLDAMLQW LLHKHHKEEV LRAGLCMEGA LLLLEMLKAT MSQPSTGSGD GAWERTFPAS
VLQFLGLVHS TYPQDPAWRA PEFLQTLAAV AFPLGAPKGA VTESAQNAPS PGAAAEGDSA
AEGLQAPAES HPSRKQLREF MQLLLKELLL MAPNPKQWLP LEVLLEACPD NATSQQKQDF
QSEVLLSAME IFHVVSGGHT PMLRGSREPP PNAEAATAPS LANISHFTQK LVEKLYSGMF
SADPRHILLF ITEHIMVVIE NASSQRDTII NALYSSLNKV ILYCLSKPQQ SLSECLSLLN
ILGFLQEHWD IVFATYNSNA SFFLCLMHCL LLLSARSYPE GFGLEPKPRM TPYHQVFLSP
NEEVREKTGE DFPSLSDVQH NIQKTVRTLW QQLVAQRRQE LEDTFKIDLS VKPGDSEVKI
EEVTPLWEET MLKAWQHYLA SEKKSLSSRS TVGHYRKVSS WSGSLSSAMR LMPGRQTKDP
ECKAEDFVSC IENYRRRGQE LYASLYKDHV QRRRCDNIKA ATAWARIQEQ LFGELGLWGQ
MAEATPCSQW ELDWREGPAR MRKRIRRLSL LEARRRERLK ESQDRNGAVS QMNAENQDEL
TAKEAESEGE EATDCTQLTF FPALHESLHS EDFLELCRER QVILQELLDH EKVTQKYSLV
IVQGHLVCEG LLLFGRQHFY VCENFTLSPV GDVYCTRHCL SNISDPFIFN MCSKDRSSDH
YSCQRHSYSD LRELRQARFL LQDIALEIFF QNGYSKFLVF HNSDRSKVFK SFCSFQPSLK
GKSFTEDPLN LRLHRARQAF PHWTQSLLPA QCLTRRYPGF DRTMLQKWQK RDISNFEYLM
YLNTLAGRTY NDYMQYPVFP WVLADYTSQT LNLTNPKTFR DLSKPMGAQT KERKLKFIQR
FKEVEKTEGD MTVQCHYCTH YSSAIIVASY LVRMPPFTQA FCSLQGGSFD VADRMFHSMK
NAWESASREN MSDVRELVPE FFYLPDFLTN CNAVEFGRMQ DGTALGDVQL PPWADGDPRK
FISLHRQALE SDFVSANLHH WIDLIFGYKQ QGSAAVEAVN TFHPYFYGDR MDLSSISDPL
IRNTILGFVS NFGQVPKQLF TKPHPARTAA GKPSPAKDVS APASLPGHPL PFFYCLQSLR
PSQVTVKGSE SPKGAIGHIV PTEKAILAVE TNKLLLPPHW SRTFSWGFDD FSCCLGSYGS
DKILMTFENL AVWGRCLCAV CPSPTMIVTS GTSAVVCVWE LSMAKGRPTG LHLKQALYGH
TQAVTCLAAS VAFNLLVSGS QDCTCTLWDL DHLTHVARLP AHREGVSAIA ISDVSGTIVS
CAGAHLSLWN VNGQPLASIT TAWGPEGAIT CCCVVEGPAW DTSHVIITGS QDGMVRIWKT
EDVKMSVPGQ AATEEPWALP PSPRGHKWEK NLALCRELDV SVALTGKPRK TSSAVTALAA
SRNQTKLLVG DEKGRIFCWS AEG
//
