ID A0A9W5UM32_9ACTN Unreviewed; 584 AA.
AC A0A9W5UM32;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:GIJ31291.1};
GN ORFNames=Vse01_04390 {ECO:0000313|EMBL:GIJ31291.1};
OS Micromonospora sediminimaris.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=547162 {ECO:0000313|EMBL:GIJ31291.1, ECO:0000313|Proteomes:UP000607311};
RN [1] {ECO:0000313|EMBL:GIJ31291.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NBRC 107745 {ECO:0000313|EMBL:GIJ31291.1};
RA Komaki H., Tamura T.;
RT "Whole genome shotgun sequence of Verrucosispora sediminis NBRC 107745.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GIJ31291.1}.
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DR EMBL; BOPD01000002; GIJ31291.1; -; Genomic_DNA.
DR RefSeq; WP_093402431.1; NZ_BOPD01000002.1.
DR AlphaFoldDB; A0A9W5UM32; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000607311; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:GIJ31291.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000607311}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 584 AA; 61009 MW; 8581A0D6FAB7E246 CRC64;
MLVVATAGHV DHGKSTLVRA LTGMEPDRWA EERRRGMTID LGFAWTSLPS GRTVAFVDVP
GHERFVPNML AGVGPVPAAV VVVAADAGWM PQSAEHLAAL DALGVGYGLL VVTRADLADP
TAALARARSE LAATSLGEVE TVTVSAATGD GLPDLRAALD RLADRLPAPV PDGPVRLWVD
RCFTVRGSGT VVTGTLGAGR LRVGDELELA GAGVPVRIRG LHRLGAACDE ALPVARVAVN
LRGVARDRIS RGDALLTPGR FQPTDLVDVR LAGVAVAELP VTLTLHVGSA AVPVRVRPLG
GDTARLRLSR PLPLLIGDRA LLRDPGRRYV AGGVTVLDVR PPPLARRGAA AARAAVLATL
DGRPELAGEL SRRGLARVGD LVRAGVPVTV APVAGDWLAD PQHWRGLGDR LAVAVAEHAR
THPLASGAPV EQLRRHLDLP DRSLVEALVK PPLRLVAGRV VAPGAASLPE PVARALALVS
EDYAAHPFRA PDADRLAAVG LGTREIGAAV RAGALLRLTG NVLLLPGAPQ QAVRVLTGLP
QPFTLSAARQ ALDTTRRVAV PLLELLDQRG LTRRLPDDAR VVVD
//
