ID A0A9W5YG08_9FIRM Unreviewed; 632 AA.
AC A0A9W5YG08;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=SH1V18_37190 {ECO:0000313|EMBL:GKX31239.1};
OS Vallitalea longa.
OC Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales; Vallitaleaceae;
OC Vallitalea.
OX NCBI_TaxID=2936439 {ECO:0000313|EMBL:GKX31239.1, ECO:0000313|Proteomes:UP001144256};
RN [1] {ECO:0000313|EMBL:GKX31239.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SH18-1 {ECO:0000313|EMBL:GKX31239.1};
RA Hirano S., Terahara T., Mori K., Hamada M., Matsumoto R., Kobayashi T.;
RT "Vallitalea longa sp. nov., an anaerobic bacterium isolated from marine
RT sediment.";
RL Submitted (JUN-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GKX31239.1}.
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DR EMBL; BRLB01000015; GKX31239.1; -; Genomic_DNA.
DR RefSeq; WP_281818095.1; NZ_BRLB01000015.1.
DR AlphaFoldDB; A0A9W5YG08; -.
DR Proteomes; UP001144256; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP001144256}.
FT DOMAIN 1..176
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 632 AA; 72056 MW; 2046AEC19432E923 CRC64;
MDHLIIGTAG HVDHGKTELV KALTGYDTDR LKEEKRRGMT IELGFAPFMI DGKTFSIVDV
PGHEKLVKTM VAGATGMDMA LLIIAADEGI MPQTIEHVNI LNVLDISNVI IVITKIDLVD
ELKLRDVIED VKEYIAQTLS MNTPICPVSS KLNLGMDKLK NMISDLSEKI IIDRNQELFR
MPIDRVFTIK GHGTVVTGTI TGGKINKDSL VEILPDKTIS KVRTIQVHGS DREKAYAGQR
CAINLSRVDK SSINRGDVIG KPNELLPTLT IDTAIYNLSE NDEIKHNQKV RINIGTTEVI
GKLKMLQRNI LSKNEKSYAR IRLEKPIIAV FEDKFIIRSL SPVITLGGGK VLSHKPTRLP
KDKNEALEYF TLLDEGNTEK IILYLLENNF KIFTIDNIFK ELYIQRQAIF QSLTQLLKQQ
LVIKLSNKYY ISQKTYLSLK NRIISAIKDY YKNNIYSIAI NKETLRTKEF PKWASIEFDT
LVKLYAKNNI INIIDDQISI NDQSRITNIS NNPQINELEK LILKSNLQGL NITKYQDTQL
LRALNNQLPN LISFLLRTGK IVQLNTTTYI HKTHYDKLIN LINNLFLQYD KITVQQVRDL
LQIGRKQTII LLEYLDQKGL TKRINNHRIL IT
//
