ID A0A9W7W3L5_9PEZI Unreviewed; 3923 AA.
AC A0A9W7W3L5;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 08-OCT-2025, entry version 9.
DE SubName: Full=Transformation/transcription domain-associated protein {ECO:0000313|EMBL:KAH9831114.1};
GN ORFNames=Tdes44962_MAKER02192 {ECO:0000313|EMBL:KAH9831114.1};
OS Teratosphaeria destructans.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Teratosphaeria.
OX NCBI_TaxID=418781 {ECO:0000313|EMBL:KAH9831114.1, ECO:0000313|Proteomes:UP001138500};
RN [1] {ECO:0000313|EMBL:KAH9831114.1, ECO:0000313|Proteomes:UP001138500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMW44962 {ECO:0000313|EMBL:KAH9831114.1};
RA Wingfield B.D., Liu M., Nguyen H.D., Lane F.A., Morgan S.W., De Vos L.,
RA Wilken P.M., Duong T.A., Aylward J., Coetzee M.P., Dadej K., De Beer Z.W.,
RA Findlay W., Havenga M., Kolarik M., Menzies J.G., Naidoo K., Pochopski O.,
RA Shoukouhi P., Santana Q.C., Seifert K.A., Soal N., Steenkamp E.T.,
RA Tatham C.T., van der Nest M.A., Wingfield M.J.;
RT "IMA Genome-F 10: Nine draft genome sequences of Claviceps purpurea s.lat.,
RT including C. arundinis, C. humidiphila, and C. cf. spartinae,
RT pseudomolecules for the pitch canker pathogen Fusarium circinatum, draft
RT genome of Davidsoniella eucalypti, Grosmannia galeiformis, Quambalaria
RT eucalypti, and Teratosphaeria destructans.";
RL IMA Fungus 0:0-0(2018).
RN [2] {ECO:0000313|EMBL:KAH9831114.1, ECO:0000313|Proteomes:UP001138500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMW44962 {ECO:0000313|EMBL:KAH9831114.1};
RX PubMed=34432124;
RA Havenga M., Wingfield B.D., Wingfield M.J., Dreyer L.L., Roets F.,
RA Aylward J.;
RT "Genetic response to nitrogen starvation in the aggressive Eucalyptus
RT foliar pathogen Teratosphaeria destructans.";
RL Curr. Genet. 67:981-990(2021).
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH9831114.1}.
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DR EMBL; RIBY02001224; KAH9831114.1; -; Genomic_DNA.
DR OrthoDB; 5570127at2759; -.
DR Proteomes; UP001138500; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0000124; C:SAGA complex; IEA:TreeGrafter.
DR GO; GO:0006281; P:DNA repair; IEA:TreeGrafter.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:TreeGrafter.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR050517; DDR_Repair_Kinase.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 2.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP001138500}.
FT DOMAIN 2731..3290
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3545..3874
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3891..3923
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 163..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2120..2142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3299..3375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..202
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..885
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1499
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2128..2140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3299..3319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3320..3337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3353..3375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3923 AA; 443048 MW; AEDB2D1B2869E01F CRC64;
MAARSLDEYE AKLQDASVDQ KIKAQYLTEL RDGLDNWCSG SSYGPFLQKF IPLFLQILSG
PPVFISTSQE QKVRSTILEI VHRLPLASTD SGVIEPHADK IVETCLGLVR VENEENAVLC
LKIVMDFCRY FAKSSAVAEK TQPFLELILE IFEGMEQTVK DTFDSPVPAS AAANAPGTPG
AVGTPGSPVS SSNPSIGSDP SADQQTTRQL AKGMQSFKVV AECPIIVVSI FQAHRSLAPK
NVGKFTPKIR STLMLQAGPQ KRAHEEAESR GVIFTGIAKE IKLKGQTAAF GDLVTAQVKT
MSFLAYLLRA YQSSLTEFLN HLPGLTVRLL RDVPRSHTAT RKELLVAIRH IINFNFRSVF
LPSILPLLDA RTLVGDSLTA DVSLRPLAYT MLADLIHHVR EQLTPDQIHR VVTVYVGHLT
GDDGVEVPGT SYQTMSAKLL LNMAECMSKV ENKKDARFLM MTVLNGIADK FAAMNRAYPN
AVKLARQQLE AGSGLDAGPE NFLAERDQKP DWDQTDLFSA MPIKALNPRD RANDAVTENQ
FLFRNLLHGL KTFFYTLKNT NPQKIKDEVD HANAPLNWAD LSYGFEAEEV EILIKLFREG
AKCFQYYAPL DQSKESENID SASNQSLASS TASSKVEKDL LETFATIFHH LDPATFHEIF
TSRTSVPDQP GASESGIEFL YEQSFKHNAL LHIPQFLLAS EATSPAFCGM LLRFLMSKLE
EVGEKDSAKT NVLLRLFKLS FMAVTLFSQH NESVLLPHVR ELITRSIEMS VTADEPTNYF
LLLRSLFRSI GGGRFEHLYK EILPLLEMLL EVLNTQLAAA KDAASRDLFV ELSLTVPARL
SHLLPHLSYL MRPLTVALRS GERTNPSESR GAAGSSDIRS GSAGSSELTA QGLRTLELCV
DNLTADYLDP IMQPWMEEIM GSLWRMLKPG SLTSTSPQQP GGALVVTGHQ GAHTAVRILG
KLGGRNRRFL TEPPELEWRG YADDEASVDV RLIGAVSNGG ERAMPVRLGV DTAVERLWEP
VPKAEKAKKS DEHYKRQAYK LVTSHVKLLI GSDDLPHDFA RLVRLQANDL ADKKFDTGID
LFSVSERQKS SVKRDAQQAT LLKLLRALMY TAGTSEILRD ESARFLQGIY RHFMLVELSV
ALAREKHKKR AFDVRSGEGP VYIETALLAD AICDSLASDL SEVRDVAEHA IQTCFKIAVT
IFGGSEERAE KLPFFHKLAE CCVHFCYEEE WFTKSAGALG ISLLINRNKI GFTDSWIAES
NLAGFNRLLD LIRGLLYVIK DMPQDLPAGI RLQAKDAIVE LVRRFGSSDL AKQGELKKKL
EDKTDQLHQI ANRLIAEVSH MNCHVREAAQ LALRSLADAL GMPIHELVNP VKDVLIQPIF
NKPLRALPFA AQIGYIDAIN FLLDMENDVL TFGEELNRLL YETLALVDAD DESLAQKPYE
YRTAESIVRL RVAGLKLLTT AIRFPGFAGG QQQQQGQSQG TPSSNSGSQG TPQQPTGGQH
RARVISIFFK SLYSKNRDVA AAANAGLKIV LAATQKLPKD LLQNGLRPIL MNVQDPRKLS
VEGLEGLRTL LQLLTNYFKV EIGTRLLDHM RQIADPQTLQ KVSFGLIESQ PKMKVVSGIF
SVFHLLPSAA VSFLSELVDR VLTLEANTRR TRSSPFREPL MLFLNHYPKE AWEHFASHLK
EAAKGRFFAQ VLAHEENSAL RDYLVNQPDA FVSAFANDSL SAEEKAQAQI NAIHAAQSVC
SFAEAGKKLV EHGTVRSALV SAAKNVQSMK EQRALPHALR LAAVQSSEQI MRVLVVYMQS
HHDDLNTLFS LLDLCTNGEL QTSPTLFSFL YKHVITSEDV EFQRKVMHRC IDVFTEKGTS
QKFKWFAFHN VMNPIMANDV MRNWDQLFQP DNKGTTLLNK AMTDAIHNKL WKPQSVADIS
DDGTQGVDHS RMELLQASAF LVKYHHNMLQ DARKDLIKFG WNYIRLEDHI NKYGAYALIA
YFIAHYETPP KIAMQVYNTL LRAHQAEGKN LVMQSLEILE PVLKKRLGGP DGRQSVWARL
PRKILTEEVS NVPQLTSIYH FLVRHPDLFY QAREGFATVM ISTISKVAQL PSPSVEARRL
ALNIFNLMWQ WEEKTIQEQG SLAGADSPDG RDGLSPDNGK KGGVANSSVR LALIKYMVQF
VAVLPERFPV SKTQEELRAQ LPMGQRPSVE TVTKSLDLLF KLLSPPYWDD LDIDAMFPKV
TEQILCADHK AEEKLEVWTM RMVNVIQILK ILVNSRSNEW IVARLPQLQK LLMKPLKSDS
IEVQLALHNA DLPDAASPKL PPLLQRILEA IPVSVAEDEL PDADSPTEEF TTFLTNSAGE
SLNNGSHMAG INLLWIMAQR KPEDVDHHIP ALLKTLQTKL AKDHINAHVP PQALAAQGMP
PPSQPSPQEV ETTTNLIIKV IEMLSARIST LGEQRRPYLS VLASLVERSH NNALCEKILM
QVESWVFNPT EPVPTLKEKT AVLQKMLLFE HRPDLTLYGK FMDLVIRIYE DPKILRSELA
VRMEHAFLIG LRSPDIEMRS RFMTIFDRAL SRSTSNRFFK LISEQQWDIL GDTFWLSQII
HLMFGTIDHT TALHLHPDDF RCLPISKLYG THTGDARAAD VMLDNSFESV INGERHFMND
VGSVRARDLL VPLGDLQHTD NQLAHDIWVS YFPMCWSTLS KDDREDIEQG LINLLTKDFH
QRQVDKRPNC VASLLEGIAR ARPNCKFPPH VMKFMAKQYD GWYVAASFME DLAMKPVIDT
STVRESNLDA LVEVYAQLEE ADLFYGTWRR RAQFVETNAA LSYEQNGIWD KAQNMYEQAQ
IKARTGSLPF SQGEYMLWED QWVLCAQKLQ QWEILEDFAK HENINDLFLE SVWRSFEKWS
DLKQLEQFES VIKAVSDAPT PRRMFFQAFS ALLKLHHSKD AQSQSVFQNI VDENIQLSIK
NWHKLPKHIT NAHIGLLQNF QQLVELHDAS VICQSLAQTN AGNLDVKSQE LKVLLSTWRD
RLPNLWDDIN AWQELVTWRQ HIFSLINQTY LSLLPQTNTN QTGNSYAYRG YHETAWIINR
FAHVARKHQM PDVCITQLSK IYTLPNIEIQ EAFLKLREQA KCHYQNRSEL TSGLDVINNT
NLNYFGQQQK AEFYTLKGMF LSRLNQKEEA HDAFGTALFF DIKAPKAWAE WGRYSDYLFK
EEPTNLDLAG NAISCYLEAS GQYKSAKSRK LLSRILWLLS LDNAEGSLAK VYAKFQGEHP
WWYWVTFIPQ LLNNLSRSEG EANVAHQILT NLAKTYPQAL HFQLRTSHED MQVIRRNQAM
KEQREKAARE AKIKGDNVKT ESPSARPDSQ SGTSRPNTAG GGDTQMTNGT SEETLKKDAA
AEERKEDTPK PKKPWEHTEA LVITLRTAFP LLYASMEAMV DQIQKHFKCP PDEDAYRLIV
ALLNDALSYV GRTPSAATAE SKLPPQTEAN ITRFAESILP PHIRKNFEQD FVAKKPTMLE
YIQKLRKWRD KLAERLDRRP TTFHLAETTH LSGFRFVWFD EVEVPGQYLQ HKDKNQDFVR
IERFLPIVDL VRGVAGCHRR LKIRGHDGSI HPFAIQHPAP RHSRREERIL QLFRIFNSTL
AKKKESRRRN LQFHLPVMVP LSPQIRMIQD DTSYITLQGV YDDYCRRNEL DKDEPTIFTM
EKLRGLSPQK QDQYLNVRME ALNHVQTRMV PKDVARQYFA ASYPSFDAFW LFRRQFSYQL
AALTYITWTM HMTVRYPNKM SIARRNGNVW GSELLPYMST TRPYFSNPEP VPFRLTPNLQ
VLMGPIHTEG IFTCALMAIA RCLTADSSYA TGSAASADGA SASTPVAGPL QNTNCELEHH
LSIFIRDEMS YWYTTSHRQS IKENELRENV QRNADAIVNK ALVIAREPAA GNLPANQSVL
DLVAKATNPE KLCQTDLLWM PWL
//
