ID A0A9W7WGU6_TRIRA Unreviewed; 507 AA.
AC A0A9W7WGU6;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE SubName: Full=Suppressor of cytokine signaling 5-like {ECO:0000313|EMBL:KAI7801092.1};
DE Flags: Fragment;
GN ORFNames=IRJ41_023343 {ECO:0000313|EMBL:KAI7801092.1};
OS Triplophysa rosa (Cave loach).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Nemacheilidae; Triplophysa.
OX NCBI_TaxID=992332 {ECO:0000313|EMBL:KAI7801092.1, ECO:0000313|Proteomes:UP001059041};
RN [1] {ECO:0000313|EMBL:KAI7801092.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Muscle {ECO:0000313|EMBL:KAI7801092.1};
RA Peng Z.;
RT "Comparative genomics reveals that relaxation of natural selection precedes
RT convergent phenotypic evolution of cavefish.";
RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAI7801092.1}.
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DR EMBL; JAFHDT010000014; KAI7801092.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9W7WGU6; -.
DR Proteomes; UP001059041; Linkage Group LG14.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001059041};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 355..450
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 445..494
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..14
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..42
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KAI7801092.1"
SQ SEQUENCE 507 AA; 56285 MW; F9E4FF53966350BF CRC64;
SLPEDRGKER ERGARPKVRQ SRSEERRDGG RRKGVRGKKK SHPSHDLASE RPVSDGFEYG
DLLNGLHGSS EGGSSSPVTE HRRWQVLGSS GSLLSEKVSA RPSLSSPTAD LGCDADSKSS
GGSRTLRQKI QDAVGQCFPI KSHSQGLSQP APATAPCSSR RKIHLSELML DSCPFPAGSD
LAQKWYLIKQ HTAPLSQEHI PDSSAAATLA AAMPVEDEED RLRERRRISI EQGVEPPPNA
QIHTFEVTAQ INPQYKLGPK LAHGMNELAG DERATLHQLL LQSCLDTLDE VAAASSVTAD
VELGAASPSA PSLTGATLVQ MDSPKSQDGQ HRVHTQIDYI HCLVPDLLRI TNLPCYWGVM
DRYQAETLLE GKPEGTFLLR DSAQEDYLFS VSFRRYGRSL HARIEQWNHN FSFDVHDPSV
FHAPTVTGLL EHYKDPNSCM FFEPLLSTPT HRTHPFSLQH ICRAVISGCT TYDGINALPL
PNALKEHLKE YHYKQRVRIR RLDAWWE
//
