ID A0A9W7WUR2_TRIRA Unreviewed; 1320 AA.
AC A0A9W7WUR2;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 18-JUN-2025, entry version 9.
DE SubName: Full=Tetratricopeptide repeat protein 21B {ECO:0000313|EMBL:KAI7808718.1};
GN ORFNames=IRJ41_012584 {ECO:0000313|EMBL:KAI7808718.1};
OS Triplophysa rosa (Cave loach).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Nemacheilidae; Triplophysa.
OX NCBI_TaxID=992332 {ECO:0000313|EMBL:KAI7808718.1, ECO:0000313|Proteomes:UP001059041};
RN [1] {ECO:0000313|EMBL:KAI7808718.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Muscle {ECO:0000313|EMBL:KAI7808718.1};
RA Peng Z.;
RT "Comparative genomics reveals that relaxation of natural selection precedes
RT convergent phenotypic evolution of cavefish.";
RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TTC21 family.
CC {ECO:0000256|ARBA:ARBA00010935}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAI7808718.1}.
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DR EMBL; JAFHDT010000006; KAI7808718.1; -; Genomic_DNA.
DR OrthoDB; 10259630at2759; -.
DR Proteomes; UP001059041; Linkage Group LG6.
DR GO; GO:0005929; C:cilium; IEA:GOC.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:TreeGrafter.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:TreeGrafter.
DR GO; GO:0061512; P:protein localization to cilium; IEA:TreeGrafter.
DR FunFam; 1.25.40.10:FF:000279; Tetratricopeptide repeat domain 21A; 1.
DR FunFam; 1.25.40.10:FF:000219; Tetratricopeptide repeat domain 21B; 1.
DR FunFam; 1.25.40.10:FF:000245; Tetratricopeptide repeat domain 21B; 1.
DR FunFam; 1.25.40.10:FF:000414; Tetratricopeptide repeat domain 21B; 1.
DR FunFam; 1.25.40.10:FF:003438; Tetratricopeptide repeat domain 21B; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 6.
DR InterPro; IPR056832; ARM_TT21_2nd.
DR InterPro; IPR056836; ARM_TT21_4th.
DR InterPro; IPR056835; ARM_TT21_5th.
DR InterPro; IPR056834; ARM_TT21_C.
DR InterPro; IPR056833; ARM_TT21_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_rpt.
DR InterPro; IPR040364; TTC21A/TTC21B.
DR PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR PANTHER; PTHR14699:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 21B; 1.
DR Pfam; PF25058; ARM_TT21; 1.
DR Pfam; PF25060; ARM_TT21_2nd; 1.
DR Pfam; PF25068; ARM_TT21_4th; 1.
DR Pfam; PF25064; ARM_TT21_5th; 1.
DR Pfam; PF25063; ARM_TT21_C; 1.
DR Pfam; PF25062; ARM_TT21_N; 1.
DR Pfam; PF13176; TPR_7; 1.
DR SMART; SM00028; TPR; 17.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF48452; TPR-like; 4.
DR PROSITE; PS50005; TPR; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP001059041};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT DOMAIN 14..236
FT /note="Tetratricopeptide repeat protein 21A/21B N-terminal
FT ARM repeat"
FT /evidence="ECO:0000259|Pfam:PF25062"
FT DOMAIN 272..544
FT /note="Tetratricopeptide repeat protein 21A/21B second ARM"
FT /evidence="ECO:0000259|Pfam:PF25060"
FT REPEAT 328..361
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 726..759
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 762..915
FT /note="Tetratricopeptide repeat protein 21A/21B fourth ARM"
FT /evidence="ECO:0000259|Pfam:PF25068"
FT DOMAIN 956..1072
FT /note="Tetratricopeptide repeat protein 21A/21B fifth ARM
FT repeats"
FT /evidence="ECO:0000259|Pfam:PF25064"
FT REPEAT 956..989
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1107..1315
FT /note="Tetratricopeptide repeat protein 21A/21B C-terminal
FT ARM"
FT /evidence="ECO:0000259|Pfam:PF25063"
SQ SEQUENCE 1320 AA; 150449 MW; 11E1D35CA3ECAAE7 CRC64;
MSCAEDEEST LALILYYSQE KFFCHIVDVS SEAQRRFSHD PIFTFLHAYG LLMLDQVLDA
IQELELLKEK KDISLCALMA LVYAHKRRPN PDRDIILELD GRVKEERKTS GPRALYYAGM
LLWLLGRSDK AREYVERMIK ISSGSKEGLV LKGWIDLRSN KEAYAKKSGK YFDESLKEKS
DVFALMGKAE YYEFRQNYSG AIEIINQVIV SYPSFLPALI KKMKLLLTLQ DWEQTVDAAQ
RLLQRDKNNL DAVRMLALYS LCREGNIGES ANQLSNLISN LDIQEPNNPE LFYRMSLAFT
RVCGRSEQVL QHTHRMVERA FTQVPGDSEL ATEMGYQLVL LGRVKEAMKW YKTAMTLDES
SVSALIGIIR CQLMEGHIED AEQQLEFLAE VQQSIGKSAE VLYLRALLAL KKRQSPDETT
NLLNDAVDTH FSALQGLPLS VEYFEKLNPD FLLEIAKEYL ALSPTKAPAP GQTPSPQLLH
CASVLDTVVK VVPGLPQAVF LMAKVRFQSG DTEAAQSGLQ HLLDQNPAHA DAHLLMAQIH
LTQGSFKLSS QSLELCLSHN FEIREHPLYH LIKAQTQRKM GQLQDSIQTL QMAMSLCGVR
RTGSSAKRQS KKTELSSADC VSVFLELAEA LWLNGEQHEA AKVMQDAINE FTGTPEELRV
TIANADLALM RGDTELALSM LRNITLEQPY YIQAKEKMAD IYLNHRKDKR LYVSCYRDLV
EKLPAAHSFL LLGDAYMNIQ EPELAIEVYE QALKKTPKDG AVASKIGKAL VKTHNYVKAI
NYYEAALKNG QQTFLRYDLA DLLMKLRQYE RCERVLQEAL AHDPVNELML LTEDCRYLVL
LAKVQSKVNK NDEALLSLQR ARDVQAKVLK RVQLEQPDSV PAQKQLAADI CAEIAKHCSI
QRGYERAVKF YKEALVYCDG DSKVMLELAQ LYLTLDAVDA CQQQCAAILK NDPVNEAATL
MMADLMFRKQ DYEQAVFHFQ QLLERKPDNY PTLSRLIDLL RRAGKLEEVP RFLEMAEKHS
QRAKFEPGFN YCKGLYLWYT GEPNDGLRHF NKARKDNDWG QNAVYNMIEI CLNPDNDTVG
GEVFENLDGD MGNSTEKQES EQLAVRTAEK LLKELKPQTP AGHVQLRILE NYCYVATKQK
ANVERALSVF IEIANSEKDY VPALLAMATA YMILKQTPRA RNQLKRIAKM NWNIIDADEF
EKSWLLLADI YIQSGKYDMA GDLLKRCLRH NKSCCKAYEY MGYIMEKEQS FRDAAMNYEK
AWKYSNQTNP TIGYKLAFNY LKAKRHVDAI DVCHKVLDAH PNYPRIRKDI LDKARAALRS
//
