ID A0A9W8YSP9_9PEZI Unreviewed; 446 AA.
AC A0A9W8YSP9;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 10-JUN-2026, entry version 11.
DE RecName: Full=Prephenate dehydrogenase [NADP(+)] {ECO:0000256|PIRNR:PIRNR036510};
DE Short=PRDH {ECO:0000256|PIRNR:PIRNR036510};
DE EC=1.3.1.13 {ECO:0000256|PIRNR:PIRNR036510};
GN Name=TYR1 {ECO:0000313|EMBL:KAJ4391717.1};
GN ORFNames=N0V93_005337 {ECO:0000313|EMBL:KAJ4391717.1};
OS Gnomoniopsis smithogilvyi.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Diaporthales; Gnomoniaceae; Gnomoniopsis.
OX NCBI_TaxID=1191159 {ECO:0000313|EMBL:KAJ4391717.1, ECO:0000313|Proteomes:UP001140453};
RN [1] {ECO:0000313|EMBL:KAJ4391717.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IMI 355082 {ECO:0000313|EMBL:KAJ4391717.1};
RA Hill R.;
RT "Tapping the CABI collections for fungal endophytes: first genome
RT assemblies for Collariella, Neodidymelliopsis, Ascochyta clinopodiicola,
RT Didymella pomorum, Didymosphaeria variabile, Neocosmospora piperis and
RT Neocucurbitaria cava.";
RL Submitted (OCT-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADPH; Xref=Rhea:RHEA:21640, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.13;
CC Evidence={ECO:0000256|ARBA:ARBA00051295,
CC ECO:0000256|PIRNR:PIRNR036510};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00060605, ECO:0000256|PIRNR:PIRNR036510}.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007964, ECO:0000256|PIRNR:PIRNR036510}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ4391717.1}.
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DR EMBL; JAPEVB010000003; KAJ4391717.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9W8YSP9; -.
DR OrthoDB; 5399569at2759; -.
DR Proteomes; UP001140453; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:TreeGrafter.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:UniProtKB-UniRule.
DR FunFam; 1.10.3660.10:FF:000002; Prephenate dehydrogenase [NADP(+)]; 1.
DR FunFam; 1.10.3660.10:FF:000004; Prephenate dehydrogenase [NADP(+)]; 1.
DR FunFam; 3.40.50.720:FF:000339; Prephenate dehydrogenase [NADP(+)]; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR050812; Preph/Arog_dehydrog.
DR InterPro; IPR003099; Prephen_DH.
DR InterPro; IPR012385; Prephenate_DH_fun.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF27505; 6PGD_Tyr1_C; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR Pfam; PF20463; PDH_C; 1.
DR PIRSF; PIRSF036510; PDH_fung; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141,
KW ECO:0000256|PIRNR:PIRNR036510};
KW NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|PIRNR:PIRNR036510};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Reference proteome {ECO:0000313|Proteomes:UP001140453};
KW Tyrosine biosynthesis {ECO:0000256|ARBA:ARBA00022498,
KW ECO:0000256|PIRNR:PIRNR036510}.
FT DOMAIN 18..299
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 446 AA; 50465 MW; 755F5989012E55EC CRC64;
MAATQSPATQ VPQDMEGFTI GIIGMGDMGK MYARRLSAAG WRIKACDQEE KYDSLLEEFG
DNNNIHIVRN GHLVSRESDY IIYSVEAAVI RHVVKEYGPS TKMNAIVGGQ TSCKAPEIAA
LEEHLPADVD IVPCHSLHGP NVDPKGQPLV LIKHRASDAS FTKVETVLRC LNSKHVYLTA
REHDRITADT QAVTHAAFLS MGKAWHAMQQ FPWEGARYVG GIENVKINLT MRIYSARWHV
YAGLAILNPE ARKQITQYAR STTELYKLML EGNYEELRAR VYAARERVFG HEDSTKWAPV
PLLRDDLLDR FSLGKKPEEG KALPNNHLSL LAMVDCWSAL GIVPYDHMIC STPLFRLWLG
VTENLFRHPE RLDDALKIAV EDNTFRSDDL EFTFAARGWA ECVSLGHFDT WRERFRETQT
FFEPRFTEAN QIGNAMIKAV LETTKE
//
