ID A0A9W9X8H5_9EURO Unreviewed; 888 AA.
AC A0A9W9X8H5;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Cytochrome c oxidase assembly protein COX16, mitochondrial {ECO:0000256|ARBA:ARBA00015368};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE AltName: Full=Cytochrome c oxidase assembly protein cox16, mitochondrial {ECO:0000256|ARBA:ARBA00019222};
GN ORFNames=N7530_000635 {ECO:0000313|EMBL:KAJ5486335.1};
OS Penicillium desertorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1303715 {ECO:0000313|EMBL:KAJ5486335.1, ECO:0000313|Proteomes:UP001147760};
RN [1] {ECO:0000313|EMBL:KAJ5486335.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IBT 17660 {ECO:0000313|EMBL:KAJ5486335.1};
RA Petersen C.;
RL Submitted (DEC-2022) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAJ5486335.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IBT 17660 {ECO:0000313|EMBL:KAJ5486335.1};
RX PubMed=36726175;
RA Petersen C., Sorensen T., Nielsen M.R., Sondergaard T.E., Sorensen J.L.,
RA Fitzpatrick D.A., Frisvad J.C., Nielsen K.L.;
RT "Comparative genomic study of the Penicillium genus elucidates a diverse
RT pangenome and 15 lateral gene transfer events.";
RL IMA Fungus 14:0-0(2023).
CC -!- FUNCTION: Required for the assembly of the mitochondrial respiratory
CC chain complex IV (CIV), also known as cytochrome c oxidase. May
CC participate in merging the COX1 and COX2 assembly lines.
CC {ECO:0000256|ARBA:ARBA00002490}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004434}.
CC -!- SIMILARITY: Belongs to the COX16 family.
CC {ECO:0000256|ARBA:ARBA00008370}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ5486335.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAPWDO010000001; KAJ5486335.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9W9X8H5; -.
DR OrthoDB; 6058203at2759; -.
DR Proteomes; UP001147760; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR CDD; cd01446; DSP_MapKP; 1.
DR CDD; cd18533; PTP_fungal; 1.
DR FunFam; 3.90.190.10:FF:000142; Protein tyrosine phosphatase (Pyp1), putative; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR020164; Cyt_c_Oxase_assmbl_COX16.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR050348; Protein-Tyr_Phosphatase.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134:SF561; PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A; 1.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR Pfam; PF14138; COX16; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP001147760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 335..451
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 589..882
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 764..873
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 200..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 888 AA; 98504 MW; 15BA56787170AF79 CRC64;
MPVFQSKTFR RAATESSSLG ERLGAFYRAR LARHPFILFG LPFMAVIVAG SFALTPAAAL
RYERYDRKVK QLSQDEAFDL GLKGPDGEEG IKRNPRRRIV GDEKEEYYRL MAKDLDQWEQ
KRVERFKGEP DGRLPGTGVV EANLPVMTGP GRSPSSPWVQ SAQGGHHDGG VTQSFQSTMS
PSTTGMMSSA AFTERSSPNY FGMAVQSPHN QQTSNPGLSM QKNWGTLPHS QPLPSPKLPM
FSQESVSAGL KNLLKTETET SRIRRESALH GSSSPQTTSW SNPSPSHSLG NFSFEQPNEL
RLPAGKNSTP TPQGATPASF PWVSAERCAE LLESSQSNTM LFDVRPFAHF RQANIKGSLN
LCIPTTLLKR RSFDTQKLEG TFTDDADKRS FACWRKSDVI IVYDSAAADL KDAAPLLNLL
NKFQAEDWKG DGLILQNGFR GFSGRFPHLI QQPQTQTTGP SSKRPSPMRI NLQSVAPVVG
GCALPESSSA VNPFFGNIRQ NMDLLGGVGQ IPLKQPDQLT EAKRQQLPSW LRGASDTKDQ
GHIISNKFLV LEKTELERMK QALTYEGPSA DTNGSPKKYR VAGIEKGTKN RYNDIYPFDH
SRVRLEGIPS GACDYVNANH ISAELTNRKY IATQAPVPDT FDDFWRVVWE QDVRLLVSLT
AEVERGQIKC HRYWESGKYG PFEVKAYSEK HINIESKGGP IDPTAGSPKA TDQHDGTNEN
PVITVRNFSI CHTSFPFEPI RDITQLQYPY WPDFGTTSQP THLLHLIEQC NKVIRATSNS
SFSREQAEPK GQRPVLVHCS AGCGRTGTFC TVDSVLDMLK RQRAQAAGGG GLDQNPSGSS
EWIGDSNLDL IAKTVEDFRR QRPSMVQNLS QYALCYESVL EWLASEMD
//
