ID A0A9W9XUV8_9EURO Unreviewed; 893 AA.
AC A0A9W9XUV8;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Cytochrome c oxidase assembly protein COX16, mitochondrial {ECO:0000256|ARBA:ARBA00015368};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE AltName: Full=Cytochrome c oxidase assembly protein cox16, mitochondrial {ECO:0000256|ARBA:ARBA00019222};
GN ORFNames=N7463_005990 {ECO:0000313|EMBL:KAJ5503116.1};
OS Penicillium fimorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1882269 {ECO:0000313|EMBL:KAJ5503116.1, ECO:0000313|Proteomes:UP001149954};
RN [1] {ECO:0000313|EMBL:KAJ5503116.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IBT 29495 {ECO:0000313|EMBL:KAJ5503116.1};
RA Petersen C.;
RL Submitted (DEC-2022) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAJ5503116.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IBT 29495 {ECO:0000313|EMBL:KAJ5503116.1};
RX PubMed=36726175;
RA Petersen C., Sorensen T., Nielsen M.R., Sondergaard T.E., Sorensen J.L.,
RA Fitzpatrick D.A., Frisvad J.C., Nielsen K.L.;
RT "Comparative genomic study of the Penicillium genus elucidates a diverse
RT pangenome and 15 lateral gene transfer events.";
RL IMA Fungus 14:0-0(2023).
CC -!- FUNCTION: Required for the assembly of the mitochondrial respiratory
CC chain complex IV (CIV), also known as cytochrome c oxidase. May
CC participate in merging the COX1 and COX2 assembly lines.
CC {ECO:0000256|ARBA:ARBA00002490}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004434}.
CC -!- SIMILARITY: Belongs to the COX16 family.
CC {ECO:0000256|ARBA:ARBA00008370}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ5503116.1}.
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DR EMBL; JAPWDS010000003; KAJ5503116.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9W9XUV8; -.
DR OrthoDB; 6058203at2759; -.
DR Proteomes; UP001149954; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR CDD; cd01446; DSP_MapKP; 1.
DR CDD; cd18533; PTP_fungal; 1.
DR FunFam; 3.90.190.10:FF:000142; Protein tyrosine phosphatase (Pyp1), putative; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR020164; Cyt_c_Oxase_assmbl_COX16.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR050348; Protein-Tyr_Phosphatase.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134:SF561; PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A; 1.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR Pfam; PF14138; COX16; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP001149954};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..450
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 588..887
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 764..878
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 150..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..283
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 99095 MW; 3D16134077B49634 CRC64;
MPVFQSKTFR RAATESSSLG ERLGAFYRAR LARHPFILFG LPFMAVIVAG SFALTPAAAL
RYERYDRKVK QLSQDEAFDL GLKGPDGEEG IKRNPRRRII GDEKEEYYRL MAKDLDQWEQ
KRVERFKGEP DGRLPGTGVV EANLPAMTGP GRSPSSPWVQ SAQGGHHDGV TQSFQSAISP
STTGMKSSAA FAEMSSPNYF GMAVQTPNNQ QISNPGLSMQ KNWGTLPNTQ PLPSPKLPVF
CQESVSAGLK NLLKTEPETS RIRRESALHG SSSPQTTSWS TPSPSHPLGN FSFAQPNGLK
LPASKTLAPI PQGATPASFP WVSAERCAEL LESSQSNTML FDVRPFAHFR QANIKGSLNL
CIPTTLLKRR SFDTQKLEGT FTDDTDKQNF ARWRKCDVII VYDSTAADLK DAAPLLSLLN
KFQAEDWKGD GLILQNGFRG FSGRFPHLIQ QSQTQTTGPS SKRPSPMRIN LQSVAPVVGG
CALPESSSAV NPFFGNIRQN MDLLGGVGQI PLKQPDQLTE AKRQQLPSWL RGASDIKDQG
HIVSNKFLIL EKTELERMKQ ALTYEGPSAD TNDDPKKYRV AGIEKGTKNR YNDIYPFDHS
RVRLEGIPSG ACDYVNATHI SAELSNRKYI ATQAPVPDTF DDFWRVVWEQ DVRLIVSLTA
EVERGQVKCH PYWESGKYGP FEVKAYSEKH ISIESGGESI NPTAGSPKAS TDRPDGTNEN
PVITVRNFSI CHTSFPFQPL RDITQLQYPY WPDFGTTSQP THLLHLIEQC NKVIRATSNS
SFSSQQAEPK GQRPVLVHCS AGCGRTGTFC TVDSVLDMLK RQRAQAQRVQ AVGGGDLDQN
PSGSTEWMED FNLDLIAKTV EDFRRQRPSM VQNLSQYALC YESVLEWLIS EMN
//
