ID A0A9X2DMA4_9BACI Unreviewed; 633 AA.
AC A0A9X2DMA4;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:MCM3713379.1};
GN ORFNames=M3202_04720 {ECO:0000313|EMBL:MCM3713379.1};
OS Halalkalibacter oceani.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Halalkalibacter.
OX NCBI_TaxID=1653776 {ECO:0000313|EMBL:MCM3713379.1, ECO:0000313|Proteomes:UP001139179};
RN [1] {ECO:0000313|EMBL:MCM3713379.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=214.1.1 {ECO:0000313|EMBL:MCM3713379.1};
RA Tran M.T., Wright A., Seuylemezian A., Eisen J., Coil D.;
RT "Comparative Genomics of Spacecraft Associated Microbes.";
RL Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MCM3713379.1}.
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DR EMBL; JAMBOL010000002; MCM3713379.1; -; Genomic_DNA.
DR RefSeq; WP_251222182.1; NZ_JAMBOL010000002.1.
DR AlphaFoldDB; A0A9X2DMA4; -.
DR Proteomes; UP001139179; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:MCM3713379.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP001139179}.
FT DOMAIN 1..174
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 633 AA; 71069 MW; E3692FAF8D2CBAE3 CRC64;
MKHYTVGMAG HIDHGKTTLT KALTEVDTDR LKEEKERNIS IELGYAPLTL TAQMEVSLID
VPGHERFIRQ MIAGVAGIDL VILVVAADEG VMPQTREHLD ILRLLGIEKG IIVMTKIDRV
DEEGRELAEL DIRDAVEGTF LEKAELFYVD SVTASGIAEL KEGLIRQLQE TESRESGGAF
RLPIDQVFTV HGQGTIVRGT VYEGAVSEGD MLELLPQNKL VRARQLQVHH QARKQGQAGQ
RVAINLGGIS KEEIRRGDVL ASSGQFETTT TIDIALTTVA SLKLPVKQRS AVKLHLGTAE
VFGKIVFFDR NELTEGNSEL VCQLRLDRPL VTKRGDRFIL RRPTPMETIG GGVVIDPEAG
SYRFGQETVN MLEQKKTATP EERLDQLLLD KKLVDVSEAG AVLQLTEPAF YEWADEHQAI
VVVAGAVTSK SVLAALRQEL LAELTEYHRA HPLRTGVKKA ELLQSYQRRY PARLLEWLLE
HSREEAFERR GPYVALMIHT AHPPAQWQKR VEQALAAVKE EGMNVTPLTD HFERQQLPAS
LIDELTHYVH ETARLYQLDD KHSVDVEVFN DYVNRLKAGT GAEFTLQEAK EISGLSRKYL
VPFLEKMDQI GLTSRQEQLR RWRDKGESKE NEA
//
