ID A0A9X2HA62_9HYPH Unreviewed; 681 AA.
AC A0A9X2HA62;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203,
GN ECO:0000313|EMBL:MCP3056375.1};
GN ORFNames=MJ956_14665 {ECO:0000313|EMBL:MCP3056375.1};
OS Aurantimonas marianensis.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Hyphomicrobiales; Aurantimonadaceae; Aurantimonas.
OX NCBI_TaxID=2920428 {ECO:0000313|EMBL:MCP3056375.1, ECO:0000313|Proteomes:UP001155220};
RN [1] {ECO:0000313|EMBL:MCP3056375.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LRZ36 {ECO:0000313|EMBL:MCP3056375.1};
RA Liu R.;
RT "Aurantimonas Liuensis sp. Nov., isolated from the hadal seawater of the
RT Mariana Trench.";
RL Submitted (MAR-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MCP3056375.1}.
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DR EMBL; JALHBS010000090; MCP3056375.1; -; Genomic_DNA.
DR RefSeq; WP_253965185.1; NZ_JALHBS010000090.1.
DR AlphaFoldDB; A0A9X2HA62; -.
DR Proteomes; UP001155220; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR FunFam; 3.30.420.340:FF:000001; UvrABC system protein C; 1.
DR FunFam; 3.40.1440.10:FF:000001; UvrABC system protein C; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR050066; UvrABC_protein_C.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; NF001824; PRK00558.1-5; 1.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF22920; UvrC_RNaseH; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; Reference proteome {ECO:0000313|Proteomes:UP001155220};
KW SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP-
KW Rule:MF_00203}.
FT DOMAIN 63..141
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 251..286
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 302..552
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..13
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 681 AA; 75102 MW; F033A721CE3F6FB0 CRC64;
MTADTQDFDD ELVPEPGNAT TETATGAGAS LVATIDWDDA GKFVAGDRVG VELITALAKR
LPNQPGVYRM FGKDGEVLYV GKARSLKKRV TSYTRMGGHT QRIARMIRET RQMEFVTTRT
ETEALLLEAN LIKRLRPRFN VLMRDDKSFP YILVSEDHEA PAIMKHRGGR SRKGSYFGPF
ASAGAVGRTI NSLQRAFLLR TCTDSVYESR TRPCLLYQIK RCSAPCTGEI GINDYQGLVN
EAKAFLSGRS NQIKSGMAAA MQEASEELDF ERAAVYRDRL AALSHVQSHQ GINPAGIEEA
DVFAIHQEGG LTSIQVFFFR TGQNWGNRAY FPKADPSLEA AEVLGAFLAQ FYDDKPAPRL
ILLPIQVEDE ALLAEALSVR AERRVEIAVP SRGLKKDLAD HAAANAREAL GRRLAETSSQ
ARLLKGLQET FALPHPPRRI EVYDNSHIMG TNAVGAMIVA GPEGFAKNQY RKFNIKGADI
TPGDDFGMMK EVMTRRFSRL LKEHGEGPQA PEPVCEDDED DDALTDTAMP AWPDLVLIDG
GKGQISAVRG IFAELGIADK VTTIGVAKGV DRDAGRERFV TEGREPFSLP PRDPVLYFLQ
RLRDEAHRFA IGSHRARRKK ELVKNPLDEI AGIGPSRKRA LLHHFGTAKA VSRAALSDLR
EVEGVSATMA KSIYDHFHER G
//
