ID A0AA37BSK5_9ARCH Unreviewed; 505 AA.
AC A0AA37BSK5;
DT 24-JAN-2024, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2024, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|HAMAP-Rule:MF_01904, ECO:0000256|NCBIfam:TIGR02751};
DE Short=PEPC {ECO:0000256|HAMAP-Rule:MF_01904};
DE Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_01904};
DE EC=4.1.1.31 {ECO:0000256|HAMAP-Rule:MF_01904, ECO:0000256|NCBIfam:TIGR02751};
GN Name=ppcA {ECO:0000256|HAMAP-Rule:MF_01904};
GN ORFNames=GCM10007108_16290 {ECO:0000313|EMBL:GGM78857.1};
OS Thermogymnomonas acidicola.
OC Archaea; Methanobacteriati; Thermoplasmatota; Thermoplasmata;
OC Thermoplasmatales; Thermogymnomonas.
OX NCBI_TaxID=399579 {ECO:0000313|EMBL:GGM78857.1, ECO:0000313|Proteomes:UP000632195};
RN [1] {ECO:0000313|EMBL:GGM78857.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 13583 {ECO:0000313|EMBL:GGM78857.1};
RX PubMed=25193709;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Walter F., Albersmeier A., Kalinowski J., Ruckert C.;
RT "Complete genome sequence of Corynebacterium casei LMG S-19264T (=DSM
RT 44701T), isolated from a smear-ripened cheese.";
RL Int. J. Syst. Evol. Microbiol. 189:76-77(2014).
RN [2] {ECO:0000313|EMBL:GGM78857.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 13583 {ECO:0000313|EMBL:GGM78857.1};
RA Sun Q., Ohkuma M.;
RL Submitted (SEP-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the irreversible beta-carboxylation of
CC phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon
CC dicarboxylic acid source for the tricarboxylic acid cycle.
CC {ECO:0000256|HAMAP-Rule:MF_01904}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=oxaloacetate + phosphate = phosphoenolpyruvate +
CC hydrogencarbonate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01904};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01904};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_01904}.
CC -!- SIMILARITY: Belongs to the PEPCase type 2 family. {ECO:0000256|HAMAP-
CC Rule:MF_01904}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GGM78857.1}.
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DR EMBL; BMNY01000003; GGM78857.1; -; Genomic_DNA.
DR RefSeq; WP_188681748.1; NZ_BMNY01000003.1.
DR AlphaFoldDB; A0AA37BSK5; -.
DR Proteomes; UP000632195; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR HAMAP; MF_01904; PEPcase_type2; 1.
DR InterPro; IPR007566; PEP_COase_arc-type.
DR InterPro; IPR015813; Pyrv/PenolPyrv_kinase-like_dom.
DR NCBIfam; TIGR02751; PEPCase_arch; 1.
DR Pfam; PF14010; PEPcase_2; 1.
DR PIRSF; PIRSF006677; UCP006677; 1.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE 3: Inferred from homology;
KW Carbon dioxide fixation {ECO:0000256|ARBA:ARBA00023300, ECO:0000256|HAMAP-
KW Rule:MF_01904};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_01904};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_01904};
KW Reference proteome {ECO:0000313|Proteomes:UP000632195}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 57262 MW; BD5E1CFD599B4EFF CRC64;
MHMVPRVMST QHPDNASPPW WQADAVIQGD GEVEETFRSY SELGVDEAMW DAEGKDVDYH
VVRKILSRYP DFFRERELGR DLFLTYRIPN ASIEGPERKV VMETLESIPV SHDVASRFYE
RKVSPVFQVI IPFTTSSKDL ISVLSYYRKV VVGKGRISLD SGMTVDEWIG DSEPKQIDII
PLIEDMPSVL KIREIVQEYV RFAYPKYMRV FIARSDPAMN YGFISATLLA KYAVHEIHRM
SEGMGIPFYP ILGAGTSVFR GRLVPGNEKR VMDEYRGYHT FTAQSAFRYD YGRDEARSAV
ESLMRNVVKE PMPVDAVQLR KVLEPYVARY QRMLESIAGL INVCARYIPP RRSRKLHIGL
FGYSRNQGGI VLPRAITFVA ALYSMGLPPE VFGISALQEM GDGDVDFIMS TYRGLREDLS
AAAGLFNWDA LDILGGSLKD EFRGMLLEDL RYLQDTLGIK PGPQDYATKK HALLSSLFLI
SMQSGHDDEA RSAVLEMARA RRTLG
//
