ID A0AA38CS46_TAXCH Unreviewed; 417 AA.
AC A0AA38CS46;
DT 24-JAN-2024, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2024, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=Nudix hydrolase domain-containing protein {ECO:0000259|PROSITE:PS51462};
DE Flags: Fragment;
GN ORFNames=KI387_014590 {ECO:0000313|EMBL:KAH9303007.1};
OS Taxus chinensis (Chinese yew) (Taxus wallichiana var. chinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Pinopsida; Pinidae; Conifers II; Cupressales; Taxaceae;
OC Taxus.
OX NCBI_TaxID=29808 {ECO:0000313|EMBL:KAH9303007.1, ECO:0000313|Proteomes:UP000824469};
RN [1] {ECO:0000313|EMBL:KAH9303007.1, ECO:0000313|Proteomes:UP000824469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ta-2019 {ECO:0000313|EMBL:KAH9303007.1};
RX PubMed=34267359;
RA Xiong X., Gou J., Liao Q., Li Y., Zhou Q., Bi G., Li C., Du R., Wang X.,
RA Sun T., Guo L., Liang H., Lu P., Wu Y., Zhang Z., Ro D.K., Shang Y.,
RA Huang S., Yan J.;
RT "The Taxus genome provides insights into paclitaxel biosynthesis.";
RL Nat. Plants 7:1026-1036(2021).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. DCP2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH9303007.1}.
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DR EMBL; JAHRHJ020000009; KAH9303007.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AA38CS46; -.
DR Proteomes; UP000824469; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0140933; F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd03672; NUDIX_Dcp2p_Nudt20; 1.
DR FunFam; 3.90.79.10:FF:000003; M7GpppN-mRNA hydrolase isoform 2; 1.
DR Gene3D; 1.10.10.1050; Dcp2, box A domain; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR007722; DCP2_BoxA.
DR InterPro; IPR036189; DCP2_BoxA_sf.
DR InterPro; IPR044099; Dcp2_NUDIX.
DR InterPro; IPR021489; DUF3143.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR23114; M7GPPPN-MRNA HYDROLASE; 1.
DR PANTHER; PTHR23114:SF17; M7GPPPN-MRNA HYDROLASE; 1.
DR Pfam; PF05026; DCP2; 1.
DR Pfam; PF11341; DUF3143; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SMART; SM01125; DCP2; 1.
DR SUPFAM; SSF140586; Dcp2 domain-like; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000824469};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 259..389
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
FT NON_TER 417
FT /evidence="ECO:0000313|EMBL:KAH9303007.1"
SQ SEQUENCE 417 AA; 46246 MW; 6BCE425CD8ED24DD CRC64;
MPCGVALEGK IRGGGNDTTS GSVRGWVGDL DVARAVGVGG TCELRRRATC AKANASASCE
SGGGGDTVDE WIKRLPDKKE PLYSHNLPCI EAWLRGLRFF QIKEDRALWH IHKPDWRAQL
SLDITDLYIS LSFCGAVIGP NLQEKSAGTY VGAIVGSNLQ VGKMCSVHSE PPPELLLKLG
TYSICVECPE QDRDSFPRLM FLVEEAHWYY EDHTREKHPN FISLSLRDFT TLLFLSCDVL
RPWVPEIHKI LTEFRKFKTQ NPVAGAIILN QHYDKCLLVK GWNRGASWGF PKGKKKMAES
DSTCAIREVM EETGYDTSNQ LNVHDCLQGY CGEKRLVLFI IGGVKEDTSF APRTKKEISE
IGWFNIMASC ILFGGLSNRN LALHGGVQGL CVPGQLQMMF GQSKLQGKGV TEQNADE
//
