ID A0AA47N109_MERPO Unreviewed; 553 AA.
AC A0AA47N109;
DT 24-JAN-2024, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2024, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE SubName: Full=Platelet-derived growth factor receptor beta {ECO:0000313|EMBL:KAK0150297.1};
GN Name=pdgfrb {ECO:0000313|EMBL:KAK0150297.1};
GN ORFNames=N1851_008786 {ECO:0000313|EMBL:KAK0150297.1};
OS Merluccius polli (Benguela hake) (Merluccius cadenati).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Merlucciidae; Merluccius.
OX NCBI_TaxID=89951 {ECO:0000313|EMBL:KAK0150297.1, ECO:0000313|Proteomes:UP001174136};
RN [1] {ECO:0000313|EMBL:KAK0150297.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C29 {ECO:0000313|EMBL:KAK0150297.1};
RC TISSUE=Fin {ECO:0000313|EMBL:KAK0150297.1};
RA Mateo J.L., Blanco-Fernandez C., Garcia-Vazquez E., Machado-Schiaffino G.;
RT "A new Merluccius polli reference genome to investigate the effects of
RT global change in West African waters.";
RL Front. Mar. Sci. 0:0-0(2023).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAK0150297.1}.
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DR EMBL; JAOPHQ010001520; KAK0150297.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AA47N109; -.
DR Proteomes; UP001174136; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005019; F:platelet-derived growth factor beta-receptor activity; IEA:TreeGrafter.
DR GO; GO:0048407; F:platelet-derived growth factor binding; IEA:TreeGrafter.
DR GO; GO:0001525; P:angiogenesis; IEA:TreeGrafter.
DR GO; GO:0060326; P:cell chemotaxis; IEA:TreeGrafter.
DR GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:TreeGrafter.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR050122; RTK.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF53; PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF25305; Ig_PDGFR_d4; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KAK0150297.1};
KW Reference proteome {ECO:0000313|Proteomes:UP001174136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 128..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..121
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 433..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..460
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 62081 MW; 0A97B25C1F02668C CRC64;
MTNGYDLRLC SVPSQIRDLT DHHLPGKRHL VTCLAEGVPA PTIQWYSCGS MLNCSNRTAV
WQPLTQDPET LTIQTNVSYN SSRKVSQVRS QVTFREPQQV TVRCETTNQG GRDKRDVKLV
SSTLFSEVAV LAAVLALVVI IIISIIILIA VWRKKPRYEI RWKVIESVSM DGHEYIYVDP
IHLPYDLTWE MPRDNLVLGP LYLVTEYCRY GDLVDYLHRN KHSFLQYHAE KNSMDSGCRI
SQGSTPTSQR KGYVSFGSEC DGGYMDMSKD EPSLYVPMQE QMDNIKYADI QPSPYESPYQ
QDLYQQQGGS SLDSTMVISD SPTLTHDDLL GFSYQVAKGM EFLASKNLFY SALKRGYRMN
KPAHASDQVY DIMGKCWDEK FEKRPEFSFL VHTMGNMLTD CYKKRYNQVS DNFLKSEHPA
VARTKPRISF PFASASPPFG PSSPAPSFSI PPDPYDPNPG PQGGGFRREA DGQEDVLTLY
NEYIIPIPDP KPEDVFGGAG VASSESPVGS LAPDKIEMDT AETLPEEDRL EEPGEKDALL
GLSGTPDVED SFL
//
