ID A0AA88J4N8_CHASR Unreviewed; 521 AA.
AC A0AA88J4N8;
DT 27-MAR-2024, integrated into UniProtKB/TrEMBL.
DT 27-MAR-2024, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
DE EC=2.3.2.27 {ECO:0000256|PIRNR:PIRNR015614};
GN ORFNames=Q5P01_024761 {ECO:0000313|EMBL:KAK2819200.1};
OS Channa striata (Snakehead murrel) (Ophicephalus striatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Channoidei; Channidae; Channa.
OX NCBI_TaxID=64152 {ECO:0000313|EMBL:KAK2819200.1, ECO:0000313|Proteomes:UP001187415};
RN [1] {ECO:0000313|EMBL:KAK2819200.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Gz {ECO:0000313|EMBL:KAK2819200.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAK2819200.1};
RA Liu H.;
RT "Chromosome-level Genome Assembly of Striped Snakehead (Channa striata).";
RL Submitted (JUL-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900,
CC ECO:0000256|PIRNR:PIRNR015614};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC subfamily. {ECO:0000256|ARBA:ARBA00006608}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAK2819200.1}.
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DR EMBL; JAUPFM010000020; KAK2819200.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AA88J4N8; -.
DR Proteomes; UP001187415; Unassembled WGS sequence.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:TreeGrafter.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-ARBA.
DR GO; GO:1990604; C:IRE1-TRAF2-ASK1 complex; IEA:UniProtKB-ARBA.
DR GO; GO:0043235; C:receptor complex; IEA:UniProtKB-ARBA.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-ARBA.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:TreeGrafter.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:UniProtKB-ARBA.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:InterPro.
DR GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:UniProtKB-ARBA.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0046328; P:regulation of JNK cascade; IEA:InterPro.
DR GO; GO:0002700; P:regulation of production of molecular mediator of immune response; IEA:UniProtKB-ARBA.
DR GO; GO:1905669; P:TORC1 complex assembly; IEA:UniProtKB-ARBA.
DR GO; GO:1905670; P:TORC2 complex disassembly; IEA:UniProtKB-ARBA.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:InterPro.
DR CDD; cd03778; MATH_TRAF2; 1.
DR FunFam; 1.20.5.170:FF:000035; TNF receptor-associated factor; 1.
DR FunFam; 3.30.40.10:FF:000189; TNF receptor-associated factor; 1.
DR FunFam; 2.60.210.10:FF:000035; TNF receptor-associated factor 2; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.210.10; Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR049342; TRAF1-6_MATH_dom.
DR InterPro; IPR037305; TRAF2_MATH.
DR InterPro; IPR049441; TRAF2_Znf.
DR InterPro; IPR049440; TRAF3/5_RING.
DR InterPro; IPR032070; TRAF_BIRC3-bd.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF146; TNF RECEPTOR-ASSOCIATED FACTOR; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF21341; TRAF2_zf; 1.
DR Pfam; PF21363; TRAF3_RING; 1.
DR Pfam; PF16673; TRAF_BIRC3_bd; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR PIRSF; PIRSF015614; TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 2.
DR SUPFAM; SSF57953; Trimerization domain of TRAF; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 2.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015614};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP001187415};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 30..69
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 121..163
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 173..220
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 371..516
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 121..163
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 173..220
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
SQ SEQUENCE 521 AA; 58982 MW; 43EE2E5E83E766BB CRC64;
MARISMDCST SLPGIPLSVL SVPMENKYKC QQCLQVLRRP VQAQCGHRFC VHCFKLLTSS
GPKPCEACRQ EEIYEEPISI LNSSEAFPDN AAGREIASLP ARCLNQGCNW TGSIKEYESQ
HEGRCENERI QCEACQNFIL RREKDRHNER ECEARTLNCK YCKIVFNFKD IKAHDEICLK
FPLQCKDCGK KKIPREKYND HIRNCTKSKS ACPFSEVGCK SLIDNGKLSE HEHGSTMEHL
RLLLPMVLSV ARTRAEASGP GEWQDDGPGL GLYRAPGEGV VEDSGAAAPL QSVDLDKKVT
ALENIVCVLN REVERSSVTM EAFAHQHRLD QEKIENVSNK VRQLERTLTM RDLQLSETEQ
MVRELQFCTY DGIFVWKISE FSRRRQDAVG GRTPAMFSPA FYSSKYGYKM CLRLYLNGDG
TGRGTHLSLF FVVMRGKYDA LLKWPFSQKV TLMLLDQNNR EHIIDAFRPD VTSTSFQKPI
SEMNIASGCP LFCPLAKLAG KSPYLRDDTI FIKAIVDLTG L
//
