ID A0AA88PPR5_9TELE Unreviewed; 830 AA.
AC A0AA88PPR5;
DT 27-MAR-2024, integrated into UniProtKB/TrEMBL.
DT 27-MAR-2024, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Suppressor of cytokine signaling 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Q8A67_010943 {ECO:0000313|EMBL:KAK2896455.1};
OS Cirrhinus molitorella (mud carp).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Cirrhinus.
OX NCBI_TaxID=172907 {ECO:0000313|EMBL:KAK2896455.1, ECO:0000313|Proteomes:UP001187343};
RN [1] {ECO:0000313|EMBL:KAK2896455.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Prfri {ECO:0000313|EMBL:KAK2896455.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAK2896455.1};
RA Liu H.;
RT "Chromosome-level Genome Assembly of mud carp (Cirrhinus molitorella).";
RL Submitted (AUG-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAK2896455.1}.
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DR EMBL; JAUYZG010000010; KAK2896455.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AA88PPR5; -.
DR Proteomes; UP001187343; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001187343};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 536..631
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 626..675
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 178..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..196
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 92309 MW; 2F6890EA09D0DF22 CRC64;
MHYLKSPRFQ GGNRGNALRI CNLIGWPPRS SLPHPSEVRS RPASPYSLNP PASSHYRPLL
HAFARLVKQE KHGLGGSEIW PRIMLSFQAT RTMAERMWDS SESNSFNSLQ TKDGCEVIFT
NKRGCGLHSM EKVGKMWGNL RSRCQALFHN DGSESHLCSQ DFDCVHCVVD LGQGAHAEPY
ETRSSTPSRT LSPLPLVTGG RRGHNCVADI PQIVEISIDK ESEDARRGPL VRRDSYSRHA
PWGGKKKHSC STKTQSSLEA DRRMGRSRGS TARRERRYGV SSIQEINDPV GAGSNGRSLS
TRSLRQRLRD TVGLCLPLPT HRRSQSAKGQ VSSKRKIHLT ELMLETCPFP PGSDLANKWH
LIKQHTAPVS PHSSTALLDA FDSTHPSPED EEERLRERRR LSIEEGVDPP PNAQIHTLEA
TSQSSSLYKL GPKMAPGVGE GLGEGRSLGT VSSISGGLSG IAAQVAASMA VPSHTVDCDS
EEDSTTLCLQ TRRPKQRHAS GDTHCSRQQG PWKVHTQIDY IHCLVPDLQA ITALPCYWGV
MDRYQAEALL DGRPEGTFLL RDSAQEDYLF SVSFRRYNRS LHARIEQWNH NFSFDAHDPC
VFHSSTVTGL LEHYKDPSAC MFFEPLLTAP LHRTFPFSLQ HLARAAICRH TTYDGIGALP
LPPTMQDFLK EYHYKQKVRV RWLEREPLLK HTSRSKHVRE LFSCLISLHI IHKQGRMREG
EKAAVSFALD NLQVCGGKVN GDLSLTSPCL NTHAQAPIHI SYQKYIPRQY FTPSVEGSRQ
VQEERAGPKS ALCAPTLPPE PRKTAITIVL SSGGTSLAVL FAYSGLATSL
//
