ID A0AA88RY93_CHASR Unreviewed; 644 AA.
AC A0AA88RY93;
DT 27-MAR-2024, integrated into UniProtKB/TrEMBL.
DT 27-MAR-2024, sequence version 1.
DT 28-JAN-2026, entry version 6.
DE RecName: Full=Suppressor of cytokine signaling 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Q5P01_021131 {ECO:0000313|EMBL:KAK2823956.1};
OS Channa striata (Snakehead murrel) (Ophicephalus striatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Channoidei; Channidae; Channa.
OX NCBI_TaxID=64152 {ECO:0000313|EMBL:KAK2823956.1, ECO:0000313|Proteomes:UP001187415};
RN [1] {ECO:0000313|EMBL:KAK2823956.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Gz {ECO:0000313|EMBL:KAK2823956.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAK2823956.1};
RA Liu H.;
RT "Chromosome-level Genome Assembly of Striped Snakehead (Channa striata).";
RL Submitted (JUL-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAK2823956.1}.
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DR EMBL; JAUPFM010000017; KAK2823956.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AA88RY93; -.
DR Proteomes; UP001187415; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001187415};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 488..583
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 578..627
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 174..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 71126 MW; C545C9C930DFA564 CRC64;
MDLDATSITS PLHVSKQLPA RSLLLLLLSP FIGHPGRPSR QARFGPFPIR VIRRKWSSFA
FPPLDGVAGF QKAPGSQGLL LMKKVGKMWS NLKSRCQTLF HNNSPGPREL RVEADAFHCV
VELGQGGTSG DGQVSGASSP SRSLLPVPMV TAGRRHHNCV SDIPQIVEIT IDKDTEDGRG
RSGGVPLARR DSYSRHAPWG GKKKHSCSTK TQSSLEADRR SGRSRGSGNR RDRRYGVSSI
QEMSDSVTGG RSLSARSLRQ RLSDTVGLCL PLPTRRRSRS SKNPVTSKRK IHLTELMLET
CPFPPGSDLA NKWHLIKQHT APVSPHSSTA LLDAFDPAHP SPEDEEERLR ERRRLSIEEG
VDPPPNAQIH TLEASLSGSS LYKLGPKMAP GMGEASGDGR ASGTGSSVGA VASGACGQVL
GAAPSAQDCD SEEDSTTLCL QARRPKQRHA SGDGHLSRQQ PGPWKVHTQI DYIHCLVPDL
LQITSLPCYW GVMDRYEAEA LLDGRPEGTF LLRDSAQEDY LFSVSFRRYN RSLHARIEQW
NHNFSFDAHD PCVFHSSTVT GLLEHYKDPS ACMFFEPLLT APLHRTFPFG LQHLARAAIC
RWTTYDGIGS LPLPPALQDF LKEYHYKQKV RVRWLEREPP LKVK
//
