ID A0AA88SYM2_CHASR Unreviewed; 406 AA.
AC A0AA88SYM2;
DT 27-MAR-2024, integrated into UniProtKB/TrEMBL.
DT 27-MAR-2024, sequence version 1.
DT 28-JAN-2026, entry version 7.
DE RecName: Full=Suppressor of cytokine signaling 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Q5P01_006329 {ECO:0000313|EMBL:KAK2853668.1};
OS Channa striata (Snakehead murrel) (Ophicephalus striatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Channoidei; Channidae; Channa.
OX NCBI_TaxID=64152 {ECO:0000313|EMBL:KAK2853668.1, ECO:0000313|Proteomes:UP001187415};
RN [1] {ECO:0000313|EMBL:KAK2853668.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Gz {ECO:0000313|EMBL:KAK2853668.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAK2853668.1};
RA Liu H.;
RT "Chromosome-level Genome Assembly of Striped Snakehead (Channa striata).";
RL Submitted (JUL-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAK2853668.1}.
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DR EMBL; JAUPFM010000004; KAK2853668.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AA88SYM2; -.
DR Proteomes; UP001187415; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001187415};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 260..355
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 350..399
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..12
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 45927 MW; F4900F46D2A2A24B CRC64;
MPSLPESEEE TVMSEKKPRG SDTRPKCGLR SWSADSYVWR GKKRSRSSCN GSNPGGLEAE
GTEDQAVRST SCPRWGRERK CSCNAIGDGL TSTDIDAVCR KALSRRSLRQ KFQDAVGQCF
PLRSHHHHHH HRHHVPGSSR PFSVLFWSKR KIHVSELMQD KCPFSPKSEL ARCWHLIKKH
AIQPNSLKDM EVPLKPNVSS SSTSPPQTPL SWEDICCSPG PGSTSLDDWN PSCPHGAECS
CSNTDYILVP DLLQINNSPC YWGVLNRFEA EELLEGQPEG TFLLRDSAQD EFLFSVSFRR
YSRSLHARIE QNGKRFSFDV RDPCMYRDPS VTGLLRHYSD PATCLFFEPL LSRPLPRTFP
FSLQHLCRAV ICSCTTYQGI NSLTLPPQLR DYLRQYHIKC DGACAV
//
