ID A0AA97MKW1_9PASS Unreviewed; 890 AA.
AC A0AA97MKW1;
DT 27-MAR-2024, integrated into UniProtKB/TrEMBL.
DT 27-MAR-2024, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE Flags: Fragment;
GN Name=Znf598 {ECO:0000313|EMBL:NXE94044.1};
GN ORFNames=MENNOV_R12781 {ECO:0000313|EMBL:NXE94044.1};
OS Menura novaehollandiae (superb lyrebird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Menuridae; Menura.
OX NCBI_TaxID=47692 {ECO:0000313|EMBL:NXE94044.1};
RN [1] {ECO:0000313|EMBL:NXE94044.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B10K-CU-030-46 {ECO:0000313|EMBL:NXE94044.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXE94044.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (DEC-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ZNF598/HEL2 family.
CC {ECO:0000256|ARBA:ARBA00035113}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXE94044.1}.
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DR EMBL; VWPS01000228; NXE94044.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AA97MKW1; -.
DR Proteomes; UP000521578; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0043022; F:ribosome binding; IEA:TreeGrafter.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:TreeGrafter.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:InterPro.
DR CDD; cd16615; RING-HC_ZNF598; 1.
DR InterPro; IPR057634; PAH_ZNF598/HEL2.
DR InterPro; IPR041888; RING-HC_ZNF598/HEL2.
DR InterPro; IPR044288; ZNF598/HEL2.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR059042; Znf_C2H2_ZNF598.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR22938:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZNF598; 1.
DR PANTHER; PTHR22938; ZINC FINGER PROTEIN 598; 1.
DR Pfam; PF23202; PAH_ZNF598; 1.
DR Pfam; PF25447; RING_ZNF598; 1.
DR Pfam; PF23208; zf_C2H2_ZNF598; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ligase {ECO:0000313|EMBL:NXE94044.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000521578};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 20..60
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 303..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..346
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..600
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXE94044.1"
FT NON_TER 890
FT /evidence="ECO:0000313|EMBL:NXE94044.1"
SQ SEQUENCE 890 AA; 99482 MW; 086C7FE6056C363E CRC64;
AEAAMAAMAG AGPGPAEGPC VLCCGELDVV ALGRCEHPIC YRCSVRMRAL CGVRYCAVCR
EELRQVVFGR KLPSFSSIDL HQLQHEKKYD IYFMDGEVYA LYRKLLQHEC SLCPDAKPFN
TFADLEQHMR KQHELFCCKL CVKHLKIFTY ERKWYSRKDL ARHRIHGDPD DTSHRGHPLC
KFCDERYLDN DELLKHLRRD HYFCHFCDSE GAQEYYSDYE YLREHFREKH FLCEEGRCSS
EQFTHAFRTE IDYKAHKSSC HSKSRAEARQ NRHIDLQFTY TPRHPRRSDG VVGAEDFEEV
DRYNRQGRAG RLSSRGNQQN RRGSWRYKRE EEDRDVAAAV RASVAAKRQE EKKRVEDKED
GSSSRGKKED LRDPDVLSSK RVPKSSNDFG LKTFLCSFFT VPKEAAANGA LSQDDFPAIG
SAAGPLQGSA QPALVKLKEE DFPSLSSSAA PTISSGMSLT YTATAKRTAF QEEDFPALVS
KMKPTNKTVP HITSAWNNGS SKNVVKAIST PCVNQPAKKP SLNTSKGSKK SNKLCESDDE
DGGGGLTSQE IRNTPTMFDV SSLLAASTSQ TFTKVSKKKK MGVEKQSPSS SRPSQDTSFP
RPSTEKPLEA EQPSKVFPAP HGPDRATAVV NGHSDKPSAA CGTPKEPPGL KKPPVTNKCP
LPQEDFPALG SSGSARMPPP PGFNSVVLLK NPPPPPGLTV PVSKPPPGFA VIPATNSSDP
VTTALKEPKS CHGSYLIPEN FQQRNIQLIQ SIKEFLQSDE SKFNKFKTHS GQFRQGLISA
AQYYKSCREL LGENFKKIFK ELLVLLPDTA KQQELLSAHN DFRIKEKQSS NKSKKNKKNV
WQTDPPADLD CSICPTCRQV LTQQDVLTHK ALHIEDEEFP SLQAISRIIS
//
