ID A0AAD1RHN0_PELCU Unreviewed; 537 AA.
AC A0AAD1RHN0;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 6.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:CAH2254920.1};
GN ORFNames=PECUL_23A060070 {ECO:0000313|EMBL:CAH2254920.1};
OS Pelobates cultripes (Western spadefoot toad).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pelobatoidea; Pelobatidae; Pelobates.
OX NCBI_TaxID=61616 {ECO:0000313|EMBL:CAH2254920.1, ECO:0000313|Proteomes:UP001295444};
RN [1] {ECO:0000313|EMBL:CAH2254920.1}
RP NUCLEOTIDE SEQUENCE.
RA Alioto T., Alioto T., Gomez Garrido J.;
RL Submitted (MAR-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; OW240913; CAH2254920.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD1RHN0; -.
DR Proteomes; UP001295444; Chromosome 02.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001295444};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 382..477
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 472..521
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 117..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 61493 MW; D209F0C30B19F232 CRC64;
MDKVGKMWNN FKYRCQNLFS HDEDGSQTDI VDVNANRCLS GSSKNDIPAS QGHLQSIVPF
QDNTASEVSF SSFSSISRRN QNCVTEMPQL VEISIEKENE LGLSVGTRLA RRDSYTRHAP
WGGKKKHSCS TKTQSSFDPD KKINRTRSSL QRRERRHCVN SVHDVEAVSI RAIGSRSLRQ
RLNETVGLCF PIRTYNRPSK PLFTNKRKIH LSELMLEKCP FPAGSDLAQK WHLIKQHTAP
INPHTNILDT FEQSVVSTED EEDRLRERRR LSIEEGVDPP PNAQIHTFEA TAQVNPVYKL
GPKLAAGMAD LSGDSSTLSQ GGCESEEDTT TLCLQSRRPK QRQVSGDSHT QVNRQGAWKV
HTQIDYIHCL VPDLIEITSN PCYWGVMDRY EAEALLEGKP EGTFLLRDSA QEDYLFSVSF
RRYNRSLHAR IEQWNHNFSF DAHDPCVFHS STVTGLLEHY KDPSSCMFFE PLLTVPLNRT
FPFSLQYICR AVICRSTTYD GIDALPMPSM LQDFLKEYHY KQKVRVRWLE REPFKSK
//
