ID A0AAD2A7Y1_9LAMI Unreviewed; 348 AA.
AC A0AAD2A7Y1;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 9.
DE RecName: Full=PHD finger protein ALFIN-LIKE {ECO:0000256|RuleBase:RU369089};
GN ORFNames=FPE_LOCUS30573 {ECO:0000313|EMBL:CAI9783143.1};
OS Fraxinus pennsylvanica.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Oleaceae; Oleeae; Fraxinus.
OX NCBI_TaxID=56036 {ECO:0000313|EMBL:CAI9783143.1, ECO:0000313|Proteomes:UP000834106};
RN [1] {ECO:0000313|EMBL:CAI9783143.1}
RP NUCLEOTIDE SEQUENCE.
RA Huff M.;
RL Submitted (MAY-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Histone-binding component that specifically recognizes H3
CC tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription
CC start sites of virtually all active genes.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SUBUNIT: Interacts with H3K4me3 and to a lesser extent with H3K4me2.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU369089}.
CC -!- DOMAIN: The PHD-type zinc finger mediates the binding to H3K4me3.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SIMILARITY: Belongs to the Alfin family.
CC {ECO:0000256|RuleBase:RU369089}.
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DR EMBL; OU503054; CAI9783143.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD2A7Y1; -.
DR Proteomes; UP000834106; Chromosome 19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:TreeGrafter.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR CDD; cd10017; B3_DNA; 1.
DR Gene3D; 2.40.330.10; DNA-binding pseudobarrel domain; 1.
DR InterPro; IPR045104; Alfin.
DR InterPro; IPR021998; Alfin_N.
DR InterPro; IPR003340; B3_DNA-bd.
DR InterPro; IPR015300; DNA-bd_pseudobarrel_sf.
DR PANTHER; PTHR12321; CPG BINDING PROTEIN; 1.
DR PANTHER; PTHR12321:SF98; PHD FINGER PROTEIN ALFIN-LIKE 5; 1.
DR Pfam; PF12165; Alfin; 1.
DR SUPFAM; SSF101936; DNA-binding pseudobarrel domain; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|RuleBase:RU369089};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU369089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369089};
KW Reference proteome {ECO:0000313|Proteomes:UP000834106};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU369089};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU369089}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|RuleBase:RU369089};
KW Zinc-finger {ECO:0000256|RuleBase:RU369089}.
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..133
FT /note="Alfin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12165"
SQ SEQUENCE 348 AA; 40209 MW; 58B8BA49E378B3D8 CRC64;
MKSRDDSQII TIPTPRCLPS LVREFKDRRT GIIKALTTGI GPLRLYGLRN GTWEVKPPVG
RAPPEFPEPV LGINLLRDQR QEKDWLSYIA VCSDAWLVSI VLYSAVYCGH KKESRETLFD
DINDLPTVLE VVTEAIQAKE LAAADNNRRF SQRIDEILQE EPIVMGNEII PYVQVQSPNP
IIVEDEIFEQ EDPIIMGNEI IPYDQIQPPN PVIMVAEITQ QVQVEYEDPD HWRIKKVLKK
SDVDCSSRLL IGRNPVLTHI APFFTNDPSE FCQNNEGLRV RVFDVNTSTE HMLMLKKWKT
NSFVLLGKWK TNFVNRRKLE ENDEVGLRWD VNSSRLEFAV LRRHQHEE
//
