ID A0AAD3ND71_LATJO Unreviewed; 557 AA.
AC A0AAD3ND71;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 7.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:GLD70163.1};
GN ORFNames=AKAME5_002148000 {ECO:0000313|EMBL:GLD70163.1};
OS Lates japonicus (Japanese lates).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=270547 {ECO:0000313|EMBL:GLD70163.1, ECO:0000313|Proteomes:UP001279410};
RN [1] {ECO:0000313|EMBL:GLD70163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kochi {ECO:0000313|EMBL:GLD70163.1};
RA Hashiguchi Y., Takahashi H.;
RT "Genome sequencing of akame (Lates japonicus).";
RL Submitted (AUG-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GLD70163.1}.
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DR EMBL; BRZM01000356; GLD70163.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD3ND71; -.
DR Proteomes; UP001279410; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001279410};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 401..496
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 491..540
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..58
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 557 AA; 61420 MW; 5748BEB5B1B3141E CRC64;
MWSNLKSKCQ TLFHNSSPGP SESRVEADAV HCVVDLGQGG GSGDAHTSRA SSPSRSLLPV
PMVTAGRRHH NCVSDIPQIV EITIDKDTED VRGGSGGVPL ARRDSYSRHA PWGGKKKHSC
STKTQSSLEA DRRSGRLRGS GNRRDRRYGV GSIQEMSDSV SGGRSLSARS LRQRLSDTVG
LCLPLPARRR SRSSKNPVAS KRKIHLTELM LETCPFPPGS DLAHKWHLIK QHTAPVSPHS
STALLDAFDP AHPSPEDEEE RLRERRRLSI EEGVDPPPNA QIHTLEASVP GSSLYKLGPK
MAPGMGEASG DGRASVTSSS VGAGSSGACG QVLGASASAQ DCDSEEDSTT LCLQARRPKQ
RHASGDGHLS RQQPGPWKVH TQIDYIHCLV PDLLQITALP CYWGVMDRYE AEALLDGRPE
GTFLLRDSAQ EDYLFSVSFR RYNRSLHARI EQWNHNFSFD AHDPCVFHSS TVTGLLEHYK
DPSACMFFEP LLTAPLHRTF PFGLQHLARA AICRWTTYDG IGSLPLPPAL HDFLKEYHYK
QKVRVRWLER EPPLKVK
//
