ID A0AAD4E924_9AGAM Unreviewed; 448 AA.
AC A0AAD4E924;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 10-JUN-2026, entry version 7.
DE RecName: Full=Prephenate dehydrogenase [NADP(+)] {ECO:0000256|PIRNR:PIRNR036510};
DE Short=PRDH {ECO:0000256|PIRNR:PIRNR036510};
DE EC=1.3.1.13 {ECO:0000256|PIRNR:PIRNR036510};
GN ORFNames=F5891DRAFT_1028282 {ECO:0000313|EMBL:KAG1901837.1};
OS Suillus fuscotomentosus.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Suillineae; Suillaceae; Suillus.
OX NCBI_TaxID=1912939 {ECO:0000313|EMBL:KAG1901837.1, ECO:0000313|Proteomes:UP001195769};
RN [1] {ECO:0000313|EMBL:KAG1901837.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FC203 {ECO:0000313|EMBL:KAG1901837.1};
RX PubMed=33355923;
RA Lofgren L.A., Nguyen N.H., Vilgalys R., Ruytinx J., Liao H.L., Branco S.,
RA Kuo A., LaButti K., Lipzen A., Andreopoulos W., Pangilinan J., Riley R.,
RA Hundley H., Na H., Barry K., Grigoriev I.V., Stajich J.E., Kennedy P.G.;
RT "Comparative genomics reveals dynamic genome evolution in host specialist
RT ectomycorrhizal fungi.";
RL New Phytol. 0:0-0(2020).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADPH; Xref=Rhea:RHEA:21640, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.13;
CC Evidence={ECO:0000256|PIRNR:PIRNR036510};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.
CC {ECO:0000256|PIRNR:PIRNR036510}.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000256|PIRNR:PIRNR036510}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG1901837.1}.
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DR EMBL; JABBWK010000020; KAG1901837.1; -; Genomic_DNA.
DR RefSeq; XP_041227412.1; XM_041361464.1.
DR AlphaFoldDB; A0AAD4E924; -.
DR GeneID; 64655762; -.
DR Proteomes; UP001195769; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:TreeGrafter.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:UniProtKB-UniRule.
DR FunFam; 3.40.50.720:FF:000339; Prephenate dehydrogenase [NADP(+)]; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR050812; Preph/Arog_dehydrog.
DR InterPro; IPR003099; Prephen_DH.
DR InterPro; IPR012385; Prephenate_DH_fun.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF27505; 6PGD_Tyr1_C; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF036510; PDH_fung; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036510};
KW Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR036510};
KW NADP {ECO:0000256|PIRNR:PIRNR036510};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Reference proteome {ECO:0000313|Proteomes:UP001195769};
KW Tyrosine biosynthesis {ECO:0000256|PIRNR:PIRNR036510}.
FT DOMAIN 16..298
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 448 AA; 49706 MW; 4084FB85462577D6 CRC64;
MFRTNVSPND PAEEHPTIGL IGMGAMGAMY AKHLSNAGWK KISVCDIPAK FESLKLQYAD
VPGITVHQDG HAVSRISDFI MYSVEAEYID RVVSQYGPST KVGAIVSGQT SVKAPEKDAF
EKYLPPDVHI VSLHSLHGPT VSPEGQPLVL IQHRAPDSSL HLVENIFRCF GSRFVYLTYE
DHDLVTANVQ AVTHAAFLTM GTAWASQRAY PWEQGQYVGG IETVKVNIML RIYANKWHVY
AGLAILNPFA RIQIDQYASS ATALFKLMLA GDEQGLRTRV YDAREQVFGT VKTERAPIFL
TEDVLDQFTI GGHPKLNGSP TTSSAPPSNS HLALLAMVDC WAHLKIQPFD HLDLAATPIF
RMWIGVAEYL FRSPNRLDSA VRSAVYDVTH RSDDLEFVIA ARGWSQCVSF GSLELYKRRF
LETASFFESR FEEASAIGSE MIKAISQS
//
