ID A0AAD4JJR7_PERFH Unreviewed; 275 AA.
AC A0AAD4JJR7;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 5.
DE RecName: Full=Protein ARV {ECO:0000256|RuleBase:RU368065};
GN ORFNames=C2S53_004678 {ECO:0000313|EMBL:KAH6834315.1};
OS Perilla frutescens var. hirtella (Perilla citriodora) (Perilla setoyensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Elsholtzieae; Perilla.
OX NCBI_TaxID=608512 {ECO:0000313|EMBL:KAH6834315.1, ECO:0000313|Proteomes:UP001190926};
RN [1] {ECO:0000313|EMBL:KAH6834315.1, ECO:0000313|Proteomes:UP001190926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PC099 {ECO:0000313|Proteomes:UP001190926};
RX PubMed=34535649;
RA Zhang Y., Shen Q., Leng L., Zhang D., Chen S., Shi Y., Ning Z., Chen S.;
RT "Incipient diploidization of the medicinal plant Perilla within 10,000
RT years.";
RL Nat. Commun. 12:0-0(2021).
CC -!- FUNCTION: Mediator of sterol homeostasis involved in sterol uptake,
CC trafficking and distribution into membranes.
CC {ECO:0000256|RuleBase:RU368065}.
CC -!- FUNCTION: Regulates also the sphingolipid metabolism.
CC {ECO:0000256|RuleBase:RU368065}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368065}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368065}.
CC -!- SIMILARITY: Belongs to the ARV1 family. {ECO:0000256|ARBA:ARBA00009187,
CC ECO:0000256|RuleBase:RU368065}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH6834315.1}.
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DR EMBL; SDAM02000052; KAH6834315.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD4JJR7; -.
DR Proteomes; UP001190926; Unassembled WGS sequence.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; IEA:TreeGrafter.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:TreeGrafter.
DR GO; GO:0032366; P:intracellular sterol transport; IEA:UniProtKB-UniRule.
DR GO; GO:0097036; P:regulation of plasma membrane sterol distribution; IEA:UniProtKB-UniRule.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016125; P:sterol metabolic process; IEA:UniProtKB-UniRule.
DR InterPro; IPR007290; Arv1.
DR PANTHER; PTHR14467; ARV1; 1.
DR PANTHER; PTHR14467:SF0; PROTEIN ARV1; 1.
DR Pfam; PF04161; Arv1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368065};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU368065};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU368065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368065};
KW Reference proteome {ECO:0000313|Proteomes:UP001190926};
KW Sphingolipid metabolism {ECO:0000256|RuleBase:RU368065};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368065};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368065};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368065}.
FT TRANSMEM 131..157
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368065"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368065"
FT TRANSMEM 195..214
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368065"
SQ SEQUENCE 275 AA; 30577 MW; ABBEA8E67E01111F CRC64;
MASYGGTTGV AESTTTDFRC VQCGFPVKTL YIQYSPGNIR LVKCGNCKAV ADGYIECEIM
ILILDLILHK PKAYRHVFYN MFNKETVNFE SLLWKSAMAY CILDIYKMWV LSTNEKEYLI
PASFTSLLLE FGKMLTGVMF GNLVFLCILF CGTRKLLSSA TGFYGCKQIL FIVIISSYFK
MFLLAMMVWG FPSSVIVIID IFVLSSNTVA LKVITNSAMM RCLAVCALAH GMKFFASQNK
VFALQSSVFP SIGVGNNRIN LPCSRSEGVF ALDGL
//
