ID A0AAD4JNL9_PERFH Unreviewed; 1036 AA.
AC A0AAD4JNL9;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Calcium-transporting ATPase {ECO:0000256|RuleBase:RU361146};
DE EC=7.2.2.10 {ECO:0000256|RuleBase:RU361146};
GN ORFNames=C2S53_020326 {ECO:0000313|EMBL:KAH6837181.1};
OS Perilla frutescens var. hirtella (Perilla citriodora) (Perilla setoyensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Elsholtzieae; Perilla.
OX NCBI_TaxID=608512 {ECO:0000313|EMBL:KAH6837181.1, ECO:0000313|Proteomes:UP001190926};
RN [1] {ECO:0000313|EMBL:KAH6837181.1, ECO:0000313|Proteomes:UP001190926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PC099 {ECO:0000313|Proteomes:UP001190926};
RX PubMed=34535649;
RA Zhang Y., Shen Q., Leng L., Zhang D., Chen S., Shi Y., Ning Z., Chen S.;
RT "Incipient diploidization of the medicinal plant Perilla within 10,000
RT years.";
RL Nat. Commun. 12:0-0(2021).
CC -!- FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of
CC calcium. {ECO:0000256|RuleBase:RU361146}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+);
CC Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.2.2.10;
CC Evidence={ECO:0000256|ARBA:ARBA00048694,
CC ECO:0000256|RuleBase:RU361146};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361146}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IIB subfamily. {ECO:0000256|ARBA:ARBA00006124,
CC ECO:0000256|RuleBase:RU361146}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361146}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH6837181.1}.
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DR EMBL; SDAM02000019; KAH6837181.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD4JNL9; -.
DR Proteomes; UP001190926; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005388; F:P-type calcium transporter activity; IEA:UniProtKB-EC.
DR CDD; cd02081; P-type_ATPase_Ca_PMCA-like; 1.
DR FunFam; 1.20.1110.10:FF:000039; Calcium-transporting ATPase; 1.
DR FunFam; 1.20.5.170:FF:000026; Calcium-transporting ATPase; 1.
DR FunFam; 2.70.150.10:FF:000006; Calcium-transporting ATPase; 1.
DR FunFam; 3.40.1110.10:FF:000011; Calcium-transporting ATPase; 1.
DR FunFam; 3.40.50.1000:FF:000011; Calcium-transporting ATPase; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR059000; ATPase_P-type_domA.
DR InterPro; IPR024750; Ca_ATPase_N_dom.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006408; P-type_ATPase_IIB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01517; ATPase-IIB_Ca; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 4.
DR PANTHER; PTHR24093:SF448; CALCIUM-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24093; CATION TRANSPORTING ATPASE; 1.
DR Pfam; PF12515; CaATP_NAI; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361146};
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU361146};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU361146};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361146}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361146};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361146};
KW Reference proteome {ECO:0000313|Proteomes:UP001190926};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361146};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361146};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361146}.
FT TRANSMEM 171..190
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 353..374
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 394..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 953..978
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT TRANSMEM 990..1009
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361146"
FT DOMAIN 116..188
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
SQ SEQUENCE 1036 AA; 113505 MW; 037B8FFEE8E38B15 CRC64;
MDDYLKKNFD VDAKRPSEEA LQRWRSAVWL VKNPRRRFRM VADLAKRAEA ERKRRKIQEK
IRVALYVQKA ALYFIDAVDR TSNQKIPDDV KQAGYNVSAD DLASIVRSHD LKRLDSHGGV
DGIAKKLSVS VENGLPSSEI STRQKFYGEN KFIEKPPRPL WMFIWDAMQD MTLIMLMVCA
VISVGVGIAT EGWPKGMYDG IGIILCIILV VVVTAISDYK QSLQFRELDK EKRNVVVQVT
RDGSRQKVSI YDLVVGDIVN LSIGDQVPAD GLYVSGYSLY IDESSLSGES EPVHIEKGRP
FLLSGTKVQE GSGKIIVTSV GMRTEWGRLM VTLSEGGEDE TPLQVKLNGV ATVIGKIGLV
FAVLTFVVLT ARYLTVKAID GEITSWSMKD VVSLLNFFAV AVTILVVAVP EGLPLAVTLS
LAFAMKKLMN DRALIRHLSA CETMGSATCI CTDKTGTLTT NHMVVTKVWL CGEESRVDSR
KPENVMNSSI SQKVKNALID ALFLNTAADV VHGKGGKMEI LGSPTETALL EFGLLFQRDF
KGRRQESRII KVEPFNSVKK RMSVLVEGAG GGGARAFIKG ASEIILEMCD KVVGKDGETV
SISEEQRKNI TTAINGFACE ALRTLCLAYR DMETTSSNEA IPEEKYTLIA LVGIKDPLRP
GVKEAVETCL AAGIMVRMVT GDNINTAKAI AKECGILTSD GVAIEGSELR DKTADQMKDI
LPKLQVMARS LPLDKHKLVS MLRKEYEEVV AVTGDGTNDA PALHEADIGL AMGIAGTEVA
KESADVVIMD DNFATILNVA KWGRSVYINI QKFVQFQLTV NIVALMTNFV CACVSGSAPL
TAVQLLWVNM IMDTLGALAL ATEPPHDGLM KQAPVGRHAN IITRVMWRNI IGQSMYQLIV
LGLLNYDGKR LLNLNAPDSD ATLRSLIFNT FVFCQVFNEI NSRDMEKINI FKGIFSSWIF
IMIMVSTVGF QVIMVQVLCN YAGTVPLSGN LWAVSVLVGA TGLLVGTLIK CMPLPNIQIT
NHHDGYEPLP SGPDLA
//
