ID A0AAD4RBC3_9BILA Unreviewed; 2221 AA.
AC A0AAD4RBC3;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 6.
DE SubName: Full=Low-density lipoprotein receptor domain class A domain-containing protein {ECO:0000313|EMBL:KAI1723671.1};
GN ORFNames=DdX_03841 {ECO:0000313|EMBL:KAI1723671.1};
OS Ditylenchus destructor.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Sphaerularioidea; Anguinidae; Anguininae;
OC Ditylenchus.
OX NCBI_TaxID=166010 {ECO:0000313|EMBL:KAI1723671.1, ECO:0000313|Proteomes:UP001201812};
RN [1] {ECO:0000313|EMBL:KAI1723671.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BazhouSP {ECO:0000313|EMBL:KAI1723671.1};
RA Zhang H., Lin R., Xie B.;
RT "Genome Sequence Resource for Two Populations of Ditylenchus destructor,
RT the Migratory Endoparasitic Phytonematode.";
RL Submitted (JAN-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAI1723671.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAKKPZ010000003; KAI1723671.1; -; Genomic_DNA.
DR Proteomes; UP001201812; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR050778; Cueball_EGF_LRP_Nidogen.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF44; LDL RECEPTOR RELATED PROTEIN 4; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 10.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
DR PROSITE; PS51120; LDLRB; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:KAI1723671.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KAI1723671.1};
KW Reference proteome {ECO:0000313|Proteomes:UP001201812};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1804..1829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 362..401
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 471..514
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 515..560
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 708..746
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 1535..1620
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 2125..2193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2144..2161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2162..2172
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2182..2193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2221 AA; 248864 MW; CF9843E60B5E4281 CRC64;
MSICRVKCCA KDIGTFLSSI EDSTNYCCHG VSSVRIDLSH CEGMSVLARN WQTLQLLTLD
PSSRNVTSAR SIISGLDENF PISMAFDVKS KSVFHVEGWS QKNHDRIKIS NFGSPGNRMP
SRREFKRKTG ISEEVLTSLA YDWVTSKLYM GVERTTGLRN LGKIEVCSAS NISDLEREPL
CGILIHRDLD SLHCLALDPI DGYMYWLNRI HKRIERAWMD GLHLDKNPFH EPVDLAKQVA
LTNGLTLDVN RRALFFIRTY MDMSQGSELV MCKLYDRTSC TIVIRNVEAY DLDIFENYLL
WSSVASGGNG DNMGHTREKG LKFCQLDRCT TADVSTIANT TFVESLKILD ESKQPQRINP
NPCAEENGRC SHLCVLIPGA PWRSCICPIG VRITEDGQTC NKEGVTKALI VAASSGLYFI
SLDTEDFIPQ PIIITKPIGD REHDNEFPED LTPVANDIQR YGDVDFDPVE EKIYWIDKEA
KRIKRCLLNG SEYEEIVNNG INREIDSIAI DIRGRNLLWL DSFNGRIELM KFDRGPNSFR
RTILSHMLYK PRGLAVDNVN SRIFFANYYD QESKIESVQL DGNDRKVLLT LSKSSWISDI
ELRPDEDQIY WSETDKSQIM SARLSDGTKL GIFSNKLKNP YSISKMGSTM FCNSLGGRSL
MAIDIDNSDI HLKGNTITRE YEISESEIYG QTSLKAIELK FKLRNLSPCD LNNGDCEHIC
IVKDRDVRKC LCSVGFELLD DEKSCRKSTN FLIFSRADVS HDLMRISTDP QSNHTLEYLH
LANVTLSPTA IALDLRLKMV YWAGDRTRHI HKESYVEGYI ARSSFNGTAS EVIYKSFSLA
SICGLTIDWN ITGNIFICNG FLNRIEVISV NGQFRRTMVW NIEPFNRLKF IAIHPGRNLF
FFAVFEQSQL SSRIMVGDMA GIINGEVNTR VLVSDAGNMT SVAVDMETNR IIWTAIENGH
GSVFSATIED NHKVVLINKS PLLAPLSIAV FHKTLYIANG KFSGSIETLA LDESGSELKR
LHNISGILSL AVAYNLGSDK KDIPTGCRNS YVLSPSHSGL SARHRVKLKS VDNPCLCMPS
QWSLDATYQN RATKDYSNKC VCPDQLHYDS VTQSCVQPRN YLLLAAGDRF ARVTIHYSAN
RSELYRMDVE PFTILPIANI EKRVSRLAVD WLSSKRYIYW ISQGSKVLAD GSTNEFKRAS
ETGENEAKTF QFDTNNCTQV FDLALDVLGR QLFISCAISH GQLSMVHIWS IKSNDELQYV
GHIAGGNAKS SATNAYAFPK ELTVFSHMNA LFYVDHSRQL ESPSIVRCQL NGHKCYVVVA
TGLPFHSDAI ILTSTSDFAK HPQNSRLVYS TATGIWSRKV NEEHPSDSFT SHTGSKYIAD
EAIEKDQRTS NAFKSANDIL HHFDFDGGGS GRYLGGYLNT LVALQDNDAI MMLFMAFVME
RDSLLEKILK LIPNTDNTVA NNFSILPQPA WASRLMDVMQ EKSITAATAV MTDPSFGTYR
FSGNFEENDI NRQGGNPKSI HNVKQSRISF EAYSPCTNSD CSHICRPVVE INSKRRNKKQ
TADGMSFDEY GKNFGREIQG DMNRKTWASE KLIAVSAGNY ECLCPIGFIL DIENGATQCI
QNVHCASWEF LCQDGKTCVH MAKKCDGWID CPDRTDEHPT MCTFPPIAQF PSAVKNDKSP
DHTLMSSIMR DWVCDDGKTA IKKYLLCDGN VDCADESDEL HCRCEHPKDY FDCTAWEYDS
SLSGNIKKEH DQVIEADCVL RAMLCDGRQH CRFGTDERSQ ICKFLPEPST INLQSLQSLL
ENGYVVASVF FILLLILALP LYCLCYICWR NSRRKSVTMN DSIQSPKHFV ASSSGRISRT
LVSMTSTPNY HHISTAIAGK QCHSTEANLL PPTTSKNVED VFNDAGKHDT RVEVALHTCT
RDCEGHPAPS CHNSLPWKTS KVCTCSGYRS VRRMPTSIEP VNISCAPPAV MMLSTCQSCS
SPVFLGQQNP HHQYIQYYDI GEQAHTVAQN IQHFPENSTD SSVLLPPPGH FHNNGESVVV
SSCNGPETAG HVHHMQMFYA PPPSAASLST YGVAKPTGML VAHRPDRLLH SSAQSRHRGG
HRLESNNAVS SCAAASFTSS AISNIRKRPP LAASTPRKKK NSRMSREKRY KIDRQRARGR
EEDDDTVDEQ EELLGQPPPA YSQHQSALAT PMSIPSTDLF VNVHNQEANS PKDYPCPNLK
Q
//
