ID A0AAD5HJS2_UMBRA Unreviewed; 276 AA.
AC A0AAD5HJS2;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 6.
DE RecName: Full=Nudix hydrolase domain-containing protein {ECO:0000259|PROSITE:PS51462};
GN ORFNames=K450DRAFT_203529 {ECO:0000313|EMBL:KAI8584658.1};
OS Umbelopsis ramanniana AG.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Umbelopsidomycetes; Umbelopsidales; Umbelopsidaceae; Umbelopsis.
OX NCBI_TaxID=1314678 {ECO:0000313|EMBL:KAI8584658.1, ECO:0000313|Proteomes:UP001206595};
RN [1] {ECO:0000313|EMBL:KAI8584658.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AG {ECO:0000313|EMBL:KAI8584658.1};
RG DOE Joint Genome Institute;
RA Mondo S.J., Amses K.R., Simmons D.R., Longcore J.E., Seto K., Alves G.H.,
RA Bonds A.E., Quandt C.A., Davis W.J., Chang Y., Letcher P.M., Powell M.J.,
RA Kuo A., Labutti K., Pangilinan J., Andreopoulos W., Tritt A., Riley R.,
RA Hundley H., Johnson J., Lipzen A., Barry K., Berbee M.L., Buchler N.E.,
RA Grigoriev I.V., Spatafora J.W., Stajich J.E., James T.Y.;
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAI8584658.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AG {ECO:0000313|EMBL:KAI8584658.1};
RX PubMed=36037379;
RA Amses K.R., Simmons D.R., Longcore J.E., Mondo S.J., Seto K.,
RA Jeronimo G.H., Bonds A.E., Quandt C.A., Davis W.J., Chang Y.,
RA Federici B.A., Kuo A., LaButti K., Pangilinan J., Andreopoulos W.,
RA Tritt A., Riley R., Hundley H., Johnson J., Lipzen A., Barry K., Lang B.F.,
RA Cuomo C.A., Buchler N.E., Grigoriev I.V., Spatafora J.W., Stajich J.E.,
RA James T.Y.;
RT "Diploid-dominant life cycles characterize the early evolution of Fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 119:0-0(2022).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. DCP2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAI8584658.1}.
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DR EMBL; MU620892; KAI8584658.1; -; Genomic_DNA.
DR RefSeq; XP_051449662.1; XM_051584715.1.
DR AlphaFoldDB; A0AAD5HJS2; -.
DR GeneID; 75910065; -.
DR Proteomes; UP001206595; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:TreeGrafter.
DR GO; GO:0140933; F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd03672; NUDIX_Dcp2p_Nudt20; 1.
DR FunFam; 1.10.10.1050:FF:000003; Decapping enzyme Dcp2, putative; 1.
DR FunFam; 3.90.79.10:FF:000003; M7GpppN-mRNA hydrolase isoform 2; 1.
DR Gene3D; 1.10.10.1050; Dcp2, box A domain; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR007722; DCP2_BoxA.
DR InterPro; IPR036189; DCP2_BoxA_sf.
DR InterPro; IPR044099; Dcp2_NUDIX.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR23114; M7GPPPN-MRNA HYDROLASE; 1.
DR PANTHER; PTHR23114:SF17; M7GPPPN-MRNA HYDROLASE; 1.
DR Pfam; PF05026; DCP2; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SMART; SM01125; DCP2; 1.
DR SUPFAM; SSF140586; Dcp2 domain-like; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP001206595};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 94..226
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
SQ SEQUENCE 276 AA; 32313 MW; 7770A28BADB8F614 CRC64;
MALANATFEE ILDDLSSRFI INVPEEELAS VERICFQIEQ AHWFYEDFVR EQKPELPSFS
LKNFSAKIFQ HCPLLRQWEH EHERAFADFM QYKIRIPVCG AIILNERLDK CLLVKGWSSK
SGWGFPKGKI NKDEENSICA AREVLEETGF DITPYMDPEN YIEITLREQR IRLYIICGVA
EESEFIPRTR KEISQIAWYK LTELPTYKID KKPVNGSKSD TDGGRHKVAS ANKFNGSRFY
MVAPFVSKLR QFVNQRRKYH DSRNSHYSVM ANTYNS
//
